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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003398000
- symbol?: flr
- synonym:
- description?: formyl peptide receptor-like 1 inhibitory protein
- formyl peptide receptor-like 1 inhibitory protein
- FPRL1 inhibitory protein
- FPRL1 inhibitory protein (FLIPr)
- formyl peptide receptor family 1 inhibitory protein
- FPRL1 inhibitory protein FLIPr
- pseudogene
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 3756037..3756442
- synteny block?: BlockID0024810
- occurrence?: in 94% of 34 strains
flr (flpI) : staphylococcal host immune cell FPR2 and Fcγ receptor inhibitor FLIPr [1]
Staphylococci secrete a host immunomodulatory protein, FLIPr, that antagonizes both immune cell chemotaxis receptor FPR2 (formerly FPRL1) and immunoglobulin Fcγ receptors. Although FLIPr sequence variants demonstrate different affinities for FPR and FcγR subclasses, each prevents IgG-mediated opsonophagocytosis, immune cell activation and intracellular killing. Two structural FLIPr variants, one from strain Mu50 and one from strain MW2, have been characterized with distinct affinities for FPR and FcγR subclasses.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1112
08BA02176:
C248_1184
11819-97:
MS7_1112 (flr)
6850:
RSAU_001038 (flr)
71193:
ST398NM01_1151
ECT-R 2:
ECTR2_1010
ED133:
—
ED98:
SAAV_1124
HO 5096 0412:
SAEMRSA15_09850
JH1:
SaurJH1_1237
JH9:
SaurJH9_1213
JKD6008:
SAA6008_01109 (flr)
JKD6159:
SAA6159_01008 (flr)
JSNZ:
JSNZ_001122
LGA251:
SARLGA251_10660 (flr)
M013:
M013TW_1088
MRSA252:
SAR1128
MSHR1132:
SAMSHR1132_10000
MSSA476:
SAS1089
Mu3:
SAHV_1146
Mu50:
SAV1156
MW2:
MW1038
RF122:
SAB1019c
ST398:
SAPIG1151
T0131:
SAT0131_01199
TCH60:
—
TW20:
SATW20_11480 (flr)
USA300_TCH1516:
USA300HOU_1092
VC40:
SAVC_04935
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERIDKLMKE
N315 MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERIDKLMKE
NCTC8325 MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERIDKLMKE
Newman MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERIDKLMKE
USA300_FPR3757 MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERIDKLMKE
************************************************************
COL SDKNLTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDGGPRDYYTFDLTRPLEENRKNIK
N315 SDKNLTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDGGPRDYYTFDLTRPLEENRKNIK
NCTC8325 SDKNLTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDGGPRDYYTFDLTRPLEENRKNIK
Newman SDKNLTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDDGPRDYYTFDLTRPLEENRKNIK
USA300_FPR3757 SDKNLTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDGGPRDYYTFDLTRPLEENRKNIK
*************************************.**********************
COL VVKNGEIDSITWY
N315 VVKNGEIDSIYWD
NCTC8325 VVKNGEIDSITWY
Newman VVKNGEIDSITWY
USA300_FPR3757 VVKNGEIDSITWY
********** *
- ↑ Cristina Prat, Jovanka Bestebroer, Carla J C de Haas, Jos A G van Strijp, Kok P M van Kessel
A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1.
J Immunol: 2006, 177(11);8017-26
[PubMed:17114475] [WorldCat.org] [DOI] (P p)Cristina Prat, Pieter-Jan Haas, Jovanka Bestebroer, Carla J C de Haas, Jos A G van Strijp, Kok P M van Kessel
A homolog of formyl peptide receptor-like 1 (FPRL1) inhibitor from Staphylococcus aureus (FPRL1 inhibitory protein) that inhibits FPRL1 and FPR.
J Immunol: 2009, 183(10);6569-78
[PubMed:19846866] [WorldCat.org] [DOI] (I p)Annette M Stemerding, Jörg Köhl, Manoj K Pandey, Annemarie Kuipers, Jeanette H Leusen, Peter Boross, Maaike Nederend, Gestur Vidarsson, Annemarie Y L Weersink, Jan G J van de Winkel, Kok P M van Kessel, Jos A G van Strijp
Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcγR antagonists that inhibit IgG-mediated effector functions.
J Immunol: 2013, 191(1);353-62
[PubMed:23740955] [WorldCat.org] [DOI] (I p)