⊟Summary[edit | edit source]

pan ID^?: SAUPAN003135000
symbol^?: opp3D
synonym:
description^?: ABC transporter ATP-binding protein
- ABC transporter ATP-binding protein
- oligopeptide ABC transporter ATP-binding protein
- oligopeptide transport ATP-binding protein
- oligopeptide transport system ATP-binding protein oppD, putative
- Oligopeptide transport ATP-binding protein oppD
- putative oligopeptide transport ATP-binding protein
- Oligopeptide/dipeptide ABC transporter, ATPase subunit
- oligopeptide/dipeptide ABC transporter, ATP-binding , C-terminal domain protein
- oligopeptide/dipeptide ABC transporter ATPase
- oligopeptide ABC superfamily ATP binding cassette transporter, ABC protein
- oligopeptide ABC superfamily ATP binding cassette transporter, ABC protein, Opp3D
- oligopeptide ABC transporter, ATP-binding protein
- oligopeptide transport system ATP-binding protein OppD homologue
- oligopeptide transport system ATP-binding protein OppD-like protein
- Peptide/nickel transport system ATP-binding protein
- peptide ABC transporter ATP-binding protein
strand^?: +
coordinates^?: 3518562..3519644
synteny block^?: BlockID0022270
occurrence^?: in 100% of 34 strains

opp3D : oligopeptide ABC transporter ATP-binding subunit D ^[1]

The oligopeptide permease 3 (opp-3) system is the primary mechanism for staphylococcal uptake of amino acid polymers from 3 to 8 residues from the environment for nutrition. Its expression appears to be induced by tyrosine, although this induction can be competitively inhibited by phenylalanine. Intriguingly, deactivation of the opp-3 system can reduce expression of the staphylococcal extracellular proteases that ultimately provide the oligopeptide substrates for opp-3 transport.

⊟Orthologs[edit | edit source]

COL:

SACOL0993 (oppD)

N315:

SA0847 (oppD)

NCTC8325:

SAOUHSC_00925

Newman:

NWMN_0858 (oppD)

USA300_FPR3757:

SAUSA300_0889 (oppD)

04-02981:

SA2981_0943 (oppD)

08BA02176:

C248_1011 (oppD)

11819-97:

MS7_0943

6850:

RSAU_000862 (oppD1)

71193:

ST398NM01_0984

ECT-R 2:

ECTR2_843

ED133:

SAOV_0934

ED98:

SAAV_0949 (oppD)

HO 5096 0412:

SAEMRSA15_08170 (oppD)

JH1:

SaurJH1_1006

JH9:

SaurJH9_0987

JKD6008:

SAA6008_00941 (oppD)

JKD6159:

SAA6159_00845 (opp3D)

JSNZ:

JSNZ_000948

LGA251:

SARLGA251_09040 (oppD)

M013:

M013TW_0910

MRSA252:

SAR0951 (oppD)

MSHR1132:

SAMSHR1132_08360

MSSA476:

SAS0858

Mu3:

SAHV_0983 (oppD)

Mu50:

SAV0988 (oppD)

MW2:

MW0870 (oppD)

RF122:

SAB0854 (oppD)

ST398:

SAPIG0984

T0131:

SAT0131_01021 (upp)

TCH60:

HMPREF0772_12257 (oppD2)

TW20:

SATW20_09860 (oppD)

USA300_TCH1516:

USA300HOU_0946 (oppD1)

VC40:

SAVC_04110

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MTERILEVNDLHVSFDITAGEVQAVRGVDFYLNKGETLAIVGESGSGKSVTTKAITKLFQ
N315            MTERILEVNDLHVSFDITAGEVQAVRGVDFYLNKGETLAIVGESGSGKSVTTKAITKLFQ
NCTC8325        MTERILEVNDLHVSFDITAGEVQAVRGVDFYLNKGETLAIVGESGSGKSVTTKAITKLFQ
Newman          MTERILEVNDLHVSFDITAGEVQAVRGVDFYLNKGETLAIVGESGSGKSVTTKAITKLFQ
USA300_FPR3757  MTERILEVNDLHVSFDITAGEVQAVRGVDFYLNKGETLAIVGESGSGKSVTTKAITKLFQ
                ************************************************************

COL             GDTGRIKKGEILFLGEDLAKKPENELIKLRGKDISMIFQDPMTSLNPTMQIGKQVMEPLI
N315            GDTGRIKKGEILFLGEDLAKKPENELIKLRGKDISMIFQDPMTSLNPTMQIGKQVMEPLI
NCTC8325        GDTGRIKKGEILFLGEDLAKKPENELIKLRGKDISMIFQDPMTSLNPTMQIGKQVMEPLI
Newman          GDTGRIKKGEILFLGEDLAKKPENELIKLRGKDISMIFQDPMTSLNPTMQIGKQVMEPLI
USA300_FPR3757  GDTGRIKKGEILFLGEDLAKKPENELIKLRGKDISMIFQDPMTSLNPTMQIGKQVMEPLI
                ************************************************************

COL             KHKNYSKAQAKKRALEILNLVGLPNAEKRFKAYPHQFSGGQRQRIVIATALACEPKVLIA
N315            KHKNYSKAQAKKRALEILNLVGLPNAEKRFKAYPHQFSGGQRQRIVIATALACEPKVLIA
NCTC8325        KHKNYSKAQAKKRALEILNLVGLPNAEKRFKAYPHQFSGGQRQRIVIATALACEPKVLIA
Newman          KHKNYSKAQAKKRALEILNLVGLPNAEKRFKAYPHQFSGGQRQRIVIATALACEPKVLIA
USA300_FPR3757  KHKNYSKAQAKKRALEILNLVGLPNAEKRFKAYPHQFSGGQRQRIVIATALACEPKVLIA
                ************************************************************

COL             DEPTTALDVTMQAQILDLMKELQQKIDTAIIFITHDLGVVANIADRVAVMYGGQMVETGD
N315            DEPTTALDVTMQAQILDLMKELQQKIDTAIIFITHDLGVVANIADRVAVMYGGQMVETGD
NCTC8325        DEPTTALDVTMQAQILDLMKELQQKIDTAIIFITHDLGVVANIADRVAVMYGGQMVETGD
Newman          DEPTTALDVTMQAQILDLMKELQQKIDTAIIFITHDLGVVANIADRVAVMYGGQMVETGD
USA300_FPR3757  DEPTTALDVTMQAQILDLMKELQQKIDTAIIFITHDLGVVANIADRVAVMYGGQMVETGD
                ************************************************************

COL             VNEIFYDPKHPYTWGLLSSMPDLSTTNDTPLLAIPGAPPDLLHPPKGDAFARRSQYALDI
N315            VNEIFYDPKHPYTWGLLSSMPDLSTTNDTPLLAIPGAPPDLLHPPKGDAFARRSQYALDI
NCTC8325        VNEIFYDPKHPYTWGLLSSMPDLSTTNDTPLLAIPGAPPDLLHPPKGDAFARRSQYALDI
Newman          VNEIFYDPKHPYTWGLLSSMPDLSTTNDTPLLAIPGAPPDLLHPPKGDAFARRSQYALDI
USA300_FPR3757  VNEIFYDPKHPYTWGLLSSMPDLSTTNDTPLLAIPGAPPDLLHPPKGDAFARRSQYALDI
                ************************************************************

COL             DFKVEPPWFKVSPTHFVKSWLLDARAPKVELPELVKQRMKPMPNNYEKPLKVERVSFNEK
N315            DFKVEPPWFKVSPTHFVKSWLLDARAPKVELPELVKQRMKPMPNNYEKPLKVERVSFNEK
NCTC8325        DFKVEPPWFKVSPTHFVKSWLLDARAPKVELPELVKQRMKPMPNNYEKPLKVERVSFNEK
Newman          DFKVEPPWFKVSPTHFVKSWLLDARAPKVELPELVKQRMKPMPNNYEKPLKVERVSFNEK
USA300_FPR3757  DFKVEPPWFKVSPTHFVKSWLLDARAPKVELPELVKQRMKPMPNNYEKPLKVERVSFNEK
                ************************************************************

↑ Aurelia Hiron, Elise Borezée-Durant, Jean-Christophe Piard, Vincent Juillard
Only one of four oligopeptide transport systems mediates nitrogen nutrition in Staphylococcus aureus.
J Bacteriol: 2007, 189(14);5119-29
[PubMed:17496096] [WorldCat.org] [DOI] (P p)Elise Borezée-Durant, Aurelia Hiron, Jean-Christophe Piard, Vincent Juillard
Dual role of the oligopeptide permease Opp3 during growth of Staphylococcus aureus in milk.
Appl Environ Microbiol: 2009, 75(10);3355-7
[PubMed:19286789] [WorldCat.org] [DOI] (I p)McKenzie K Lehman, Austin S Nuxoll, Kelsey J Yamada, Tammy Kielian, Steven D Carson, Paul D Fey
Protease-Mediated Growth of Staphylococcus aureus on Host Proteins Is opp3 Dependent.
mBio: 2019, 10(2);
[PubMed:31040245] [WorldCat.org] [DOI] (I e) Imran Khan, Sandy J MacDonald, Sigurbjorn Markusson et al. Distinct roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages. Epub ahead of print. BioRxiv. doi: https://doi.org/10.1101/2024.12.02.626324

[1] Aurelia Hiron, Elise Borezée-Durant, Jean-Christophe Piard, Vincent Juillard
Only one of four oligopeptide transport systems mediates nitrogen nutrition in Staphylococcus aureus.
J Bacteriol: 2007, 189(14);5119-29
[PubMed:17496096] [WorldCat.org] [DOI] (P p)Elise Borezée-Durant, Aurelia Hiron, Jean-Christophe Piard, Vincent Juillard
Dual role of the oligopeptide permease Opp3 during growth of Staphylococcus aureus in milk.
Appl Environ Microbiol: 2009, 75(10);3355-7
[PubMed:19286789] [WorldCat.org] [DOI] (I p)McKenzie K Lehman, Austin S Nuxoll, Kelsey J Yamada, Tammy Kielian, Steven D Carson, Paul D Fey
Protease-Mediated Growth of Staphylococcus aureus on Host Proteins Is opp3 Dependent.
mBio: 2019, 10(2);
[PubMed:31040245] [WorldCat.org] [DOI] (I e) Imran Khan, Sandy J MacDonald, Sigurbjorn Markusson et al. Distinct roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages. Epub ahead of print. BioRxiv. doi: https://doi.org/10.1101/2024.12.02.626324

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]