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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002626000
- symbol?: queF
- synonym:
- description?: 7-cyano-7-deazaguanine reductase
- 7-cyano-7-deazaguanine reductase
- NADPH-dependent 7-cyano-7-deazaguanine reductase QueF
- preQ(1) synthase
- GTP cyclohydrolase I family protein
- NADPH-dependent 7-cyano-7-deazaguanine reductase
- NADPH-dependent 7-cyano-7-deazaguanine reductase (nadph-dependent nitrile oxidoreductase)
- NADPH dependent preQ0 reductase
- Queuosine biosynthesis protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 3130691..3131192
- synteny block?: BlockID0018610
- occurrence?: in 100% of 34 strains
queF : 7-cyano-7-deazaguanine reductase [1]
QueF is the fourth committed step in the de novo synthesis of the heavily-modified nucleobase queuosine. Its substrate, 7-cyano-7-deazaguanine (preQ0), is provided by the nitrile synthetase QueC. QueF catalyzes a pair of nitrile reductions resulting in conversion to a primary amine, generating 7-aminomethyl-7-deazaguanine (preQ1). This is the form of proto-queuosine that is exchanged with nucleobases and subsequent modifications will occur within nucleotide polymers.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0706
08BA02176:
C248_0815
11819-97:
MS7_0779 (queF)
6850:
RSAU_000703 (queF)
71193:
ST398NM01_0805
ECT-R 2:
ECTR2_678 (queF)
ED133:
SAOV_0763c
ED98:
SAAV_0689
HO 5096 0412:
SAEMRSA15_06540
JH1:
SaurJH1_0769
JH9:
SaurJH9_0751
JKD6008:
SAA6008_00743 (folE)
JKD6159:
SAA6159_00683 (folE)
JSNZ:
JSNZ_000698 (queF)
LGA251:
SARLGA251_06610 (queF)
M013:
M013TW_0714
MRSA252:
SAR0782
MSHR1132:
SAMSHR1132_06730
MSSA476:
SAS0693
Mu3:
SAHV_0725
Mu50:
SAV0728
MW2:
MW0690
RF122:
SAB0678c
ST398:
SAPIG0805
T0131:
SAT0131_00798
TCH60:
HMPREF0772_12457 (queF)
TW20:
SATW20_08030 (queF)
USA300_TCH1516:
USA300HOU_0752
VC40:
SAVC_03275
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAHGRQQDELQDITLLGNQDNTYNFDYRPDVLESFDNKHQGRDYFVKFNCPEFTSLCPIT
N315 MAHGRQQDELQDITLLGNQDNTYNFDYRPDVLESFDNKHQGRDYFVKFNCPEFTSLCPIT
NCTC8325 MAHGRQQDELQDITLLGNQDNTYNFDYRPDVLESFDNKHQGRDYFVKFNCPEFTSLCPIT
Newman MAHGRQQDELQDITLLGNQDNTYNFDYRPDVLESFDNKHQGRDYFVKFNCPEFTSLCPIT
USA300_FPR3757 MAHGRQQDELQDITLLGNQDNTYNFDYRPDVLESFDNKHQGRDYFVKFNCPEFTSLCPIT
************************************************************
COL GQPDFATIYISYIPNVKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEV
N315 GQPDFATIYISYIPNVKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEV
NCTC8325 GQPDFATIYISYIPNVKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEV
Newman GQPDFATIYISYIPNVKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEV
USA300_FPR3757 GQPDFATIYISYIPNVKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEV
************************************************************
COL WGKFTPRGGISIDPYTNYGRPNSKYEKMAEHRLMNHDLYPEKIDNR
N315 WGKFTPRGGISIDPYTNYGRPNSKYEKMAEHRLMNHDLYPEKIDNR
NCTC8325 WGKFTPRGGISIDPYTNYGRPNSKYEKMAEHRLMNHDLYPEKIDNR
Newman WGKFTPRGGISIDPYTNYGRPNSKYEKMAEHRLMNHDLYPEKIDNR
USA300_FPR3757 WGKFTPRGGISIDPYTNYGRPNSKYEKMAEHRLMNHDLYPEKIDNR
**********************************************
- ↑ Geoffrey Hutinet, Manal A Swarjo, Valérie de Crécy-Lagard
Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways.
RNA Biol: 2017, 14(9);1175-1184
[PubMed:27937735] [WorldCat.org] [DOI] (I p)Laura Antoine, Philippe Wolff, Eric Westhof, Pascale Romby, Stefano Marzi
Mapping post-transcriptional modifications in Staphylococcus aureus tRNAs by nanoLC/MSMS.
Biochimie: 2019, 164;60-69
[PubMed:31295507] [WorldCat.org] [DOI] (I p)Jorge Díaz-Rullo, José Eduardo González-Pastor
tRNA queuosine modification is involved in biofilm formation and virulence in bacteria.
Nucleic Acids Res: 2023, 51(18);9821-9837
[PubMed:37638766] [WorldCat.org] [DOI] (I p)Valérie de Crécy-Lagard, Geoffrey Hutinet, José D D Cediel-Becerra, Yifeng Yuan, Rémi Zallot, Marc G Chevrette, R M Madhushi N Ratnayake, Marshall Jaroch, Samia Quaiyum, Steven Bruner
Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages.
Microbiol Mol Biol Rev: 2024, 88(1);e0019923
[PubMed:38421302] [WorldCat.org] [DOI] (I p)