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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002512000
- symbol?: tagA
- synonym:
- description?: teichoic acid biosynthesis protein
- teichoic acid biosynthesis protein
- N-acetylmannosaminyltransferase
- N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase TarA
- UDP-N-acetyl-D-mannosamine transferase, putative
- WecB/TagA/CpsF family glycosyltransferase
- putative N-acetylmannosaminyltransferase
- N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase
- UDP-N-acetyl-D-mannosamine transferase
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3025029..3025779
- synteny block?: BlockID0017480
- occurrence?: in 100% of 34 strains
tarA (tagA) : undecaprenylpyrophosphoryl-N-acetylglucosamine N-acetylmannosaminyltransferase [1]
TarA catalyzes the second step of teichoic acid synthesis, adding a N-acetylmannosamine sugar to undecaprenol-pyrophosphate-linked N-acetylglucosamine monosaccharide. Wall teichoic acids in S. aureus use ribitol excusively as their polyol monomer, therefore WTA enzymes in S. aureus are assigned the "tar" nomenclature. In contrast, S. epidermidis uses glycerol as its polyol monomer so orthologous enzymes in S. epidermidis are assigned the "tag" nomenclature. TarA acts well upstream of teichoic acid ribitol polymerization but by convention retains the "Tar" nomenclature.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0612 (tagA)
08BA02176:
C248_0718 (tagA)
11819-97:
MS7_0687 (tagA)
6850:
RSAU_000592 (tagA)
71193:
ST398NM01_0715
ECT-R 2:
ECTR2_588
ED133:
SAOV_0671 (tagA)
ED98:
SAAV_0599 (tagA)
HO 5096 0412:
SAEMRSA15_05620 (tagA)
JH1:
SaurJH1_0674
JH9:
SaurJH9_0659
JKD6008:
SAA6008_00653 (wecG)
JKD6159:
SAA6159_00591 (wecG)
JSNZ:
JSNZ_000603 (tarA)
LGA251:
SARLGA251_05700 (tagA)
M013:
M013TW_0624
MRSA252:
SAR0646 (tagA)
MSHR1132:
SAMSHR1132_05820
MSSA476:
SAS0602
Mu3:
SAHV_0633 (tagA)
Mu50:
SAV0636 (tagA)
MW2:
MW0598 (tagA)
RF122:
SAB0586 (tagA)
ST398:
SAPIG0715
T0131:
SAT0131_00705 (gatC)
TCH60:
HMPREF0772_12551 (tagA)
TW20:
SATW20_07110 (tagA)
USA300_TCH1516:
USA300HOU_0656 (tagA)
VC40:
SAVC_02815
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTVEERSNTAKVDILGVDFDNTTMLQMVENIKTFFANQSTNNLFIVTANPEIVNYATTHQ
N315 MTVEERSNTAKVDILGVDFDNTTMLQMVENIKTFFANQSTNNLFIVTANPEIVNYATTHQ
NCTC8325 MTVEERSNTAKVDILGVDFDNTTMLQMVENIKTFFANQSTNNLFIVTANPEIVNYATTHQ
Newman MTVEERSNTAKVDILGVDFDNTTMLQMVENIKTFFANQSTNNLFIVTANPEIVNYATTHQ
USA300_FPR3757 MTVEERSNTAKVDILGVDFDNTTMLQMVENIKTFFANQSTNNLFIVTANPEIVNYATTHQ
************************************************************
COL AYLELINQASYIVADGTGVVKASHRLKQPLAHRIPGIELMDECLKIAHVNHQKVFLLGAT
N315 AYLELINQASYIVADGTGVVKASHRLKQPLAHRIPGIELMDECLKIAHVNHQKVFLLGAT
NCTC8325 AYLELINQASYIVADGTGVVKASHRLKQPLAHRIPGIELMDECLKIAHVNHQKVFLLGAT
Newman AYLELINQASYIVADGTGVVKASHRLKQPLAHRIPGIELMDECLKIAHVNHQKVFLLGAT
USA300_FPR3757 AYLELINQASYIVADGTGVVKASHRLKQPLAHRIPGIELMDECLKIAHVNHQKVFLLGAT
************************************************************
COL NEVVEAAQYALQQRYPNISFAHHHGYIDLEDETVVKRIKLFKPDYIFVGMGFPKQEEWIM
N315 NEVVEAAQYALQQRYPNISFAHHHGYIDLEDETVVKRIKLFKPDYIFVGMGFPKQEEWIM
NCTC8325 NEVVEAAQYALQQRYPNISFAHHHGYIDLEDETVVKRIKLFKPDYIFVGMGFPKQEEWIM
Newman NEVVEAAQYALQQRYPNISFAHHHGYIDLEDETVVKRIKLFKPDYIFVGMGFPKQEEWIM
USA300_FPR3757 NEVVEAAQYALQQRYPNISFAHHHGYIDLEDETVVKRIKLFKPDYIFVGMGFPKQEEWIM
************************************************************
COL THENQFESTVMMGVGGSLEVFAGAKKRAPYIFRKLNIEWIYRALIDWKRIGRLKSIPIFM
N315 THENQFESTVMMGVGGSLEVFAGAKKRAPYIFRKLNIEWIYRALIDWKRIGRLKSIPIFM
NCTC8325 THENQFESTVMMGVGGSLEVFAGAKKRAPYIFRKLNIEWIYRALIDWKRIGRLKSIPIFM
Newman THENQFESTVMMGVGGSLEVFAGAKKRAPYIFRKLNIEWIYRALIDWKRIGRLKSIPIFM
USA300_FPR3757 THENQFESTVMMGVGGSLEVFAGAKKRAPYIFRKLNIEWIYRALIDWKRIGRLKSIPIFM
************************************************************
COL YKIAKAKRKIKKAK
N315 YKIAKAKRKIKKAK
NCTC8325 YKIAKAKRKIKKAK
Newman YKIAKAKRKIKKAK
USA300_FPR3757 YKIAKAKRKIKKAK
**************
- ↑ Ziliang Qian, Yanbin Yin, Yong Zhang, Lingyi Lu, Yixue Li, Ying Jiang
Genomic characterization of ribitol teichoic acid synthesis in Staphylococcus aureus: genes, genomic organization and gene duplication.
BMC Genomics: 2006, 7;74
[PubMed:16595020] [WorldCat.org] [DOI] (I e)Orlando E Martinez, Brendan J Mahoney, Andrew K Goring, Sung-Wook Yi, Denise P Tran, Duilio Cascio, Martin L Phillips, Musleh M Muthana, Xi Chen, Michael E Jung, Joseph A Loo, Robert T Clubb
Insight into the molecular basis of substrate recognition by the wall teichoic acid glycosyltransferase TagA.
J Biol Chem: 2022, 298(2);101464
[PubMed:34864059] [WorldCat.org] [DOI] (I p)