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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002243000
- symbol?: pth
- synonym:
- description?: peptidyl-tRNA hydrolase
- peptidyl-tRNA hydrolase
- aminoacyl-tRNA hydrolase
- putative peptidyl-tRNA hydrolase
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2748962..2749534
- synteny block?: BlockID0015420
- occurrence?: in 100% of 34 strains
pth : peptidyl-tRNA hydrolase [1]
• A crystal structure is available : 4YLY
Premature translation termination can leave peptide polymers inappropriately attached to a transfer RNA. Peptidyl-tRNA hydrolase cleaves peptide polymers from transfer RNA, recycling functional tRNAs for future use.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0477 (pth)
08BA02176:
C248_0558
11819-97:
MS7_0479 (pth)
6850:
RSAU_000441 (pth)
71193:
ST398NM01_0568
ECT-R 2:
ECTR2_442 (pth)
ED133:
SAOV_0524
ED98:
SAAV_0449 (pth)
HO 5096 0412:
SAEMRSA15_04280
JH1:
SaurJH1_0537
JH9:
SaurJH9_0524
JKD6008:
SAA6008_00507 (pth)
JKD6159:
SAA6159_00453 (pth)
JSNZ:
JSNZ_000442 (pth)
LGA251:
SARLGA251_04360
M013:
M013TW_0474
MRSA252:
SAR0503
MSHR1132:
SAMSHR1132_04460
MSSA476:
SAS0459
Mu3:
SAHV_0499 (pth)
Mu50:
SAV0502 (pth)
MW2:
MW0457 (pth)
RF122:
SAB0451
ST398:
SAPIG0568 (pth)
T0131:
SAT0131_00548
TCH60:
HMPREF0772_10017 (pth)
TW20:
SATW20_05700
USA300_TCH1516:
USA300HOU_0496 (pth)
VC40:
SAVC_02095
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIE
N315 MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIE
NCTC8325 MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIE
Newman MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIE
USA300_FPR3757 MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIE
************************************************************
COL PMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKM
N315 PMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKM
NCTC8325 PMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKM
Newman PMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKM
USA300_FPR3757 PMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKM
************************************************************
COL LGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDH
N315 LGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDH
NCTC8325 LGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDH
Newman LGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDH
USA300_FPR3757 LGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDH
************************************************************
COL VMNEFNGEVK
N315 VMNEFNGEVK
NCTC8325 VMNEFNGEVK
Newman VMNEFNGEVK
USA300_FPR3757 VMNEFNGEVK
**********
- ↑ Paul D Bonin, Gil H Choi, Catherine M Trepod, John E Mott, Stephen B Lyle, Joyce I Cialdella, Ronald W Sarver, Vincent P Marshall, Laurence A Erickson
Expression, purification, and characterization of peptidyl-tRNA hydrolase from Staphylococcus aureus.
Protein Expr Purif: 2002, 24(1);123-30
[PubMed:11812233] [WorldCat.org] [DOI] (P p)Fan Zhang, Yang Song, Liwen Niu, Maikun Teng, Xu Li
Crystal structure of Staphylococcus aureus peptidyl-tRNA hydrolase at a 2.25 Å resolution.
Acta Biochim Biophys Sin (Shanghai): 2015, 47(12);1005-10
[PubMed:26508479] [WorldCat.org] [DOI] (I p)