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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002216000
- symbol?: tmk
- synonym:
- description?: thymidylate kinase
- thymidylate kinase
- dTMP kinase
- putative thymidylate kinase
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2730702..2731334
- synteny block?: BlockID0015150
- occurrence?: in 100% of 34 strains
tmk : thymidylate kinase [1]
• A crystal structure is available: 4F4I
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0457
08BA02176:
C248_0536 (tmk)
11819-97:
MS7_0459 (tmk)
6850:
RSAU_000419 (tmk)
71193:
ST398NM01_0548
ECT-R 2:
ECTR2_422 (tmk)
ED133:
SAOV_0503
ED98:
SAAV_0428 (tmk)
HO 5096 0412:
SAEMRSA15_04080 (tmk)
JH1:
SaurJH1_0516 (tmk)
JH9:
SaurJH9_0503 (tmk)
JKD6008:
SAA6008_00486 (tmk)
JKD6159:
SAA6159_00433 (tmk)
LGA251:
SARLGA251_04160 (tmk)
M013:
M013TW_0451
MRSA252:
SAR0483 (tmk)
MSHR1132:
SAMSHR1132_04260
MSSA476:
SAS0439 (tmk)
Mu3:
SAHV_0479 (tmk)
Mu50:
SAV0482 (tmk)
MW2:
MW0437 (tmk)
RF122:
SAB0431 (tmk)
ST398:
SAPIG0548 (tmk)
T0131:
SAT0131_00525 (ribH)
TCH60:
HMPREF0772_10039 (tmk)
TW20:
SATW20_05500 (tmk)
USA300_TCH1516:
USA300HOU_0481 (tmk)
VC40:
SAVC_01995 (tmk)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 | |
| JSNZ |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL -----MSAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGN
N315 -----MSAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGN
NCTC8325 -----MSAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGN
Newman MRMNKMSAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGN
USA300_FPR3757 -----MSAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGN
*******************************************************
COL DMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRAL
N315 DMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRAL
NCTC8325 DMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRAL
Newman DMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRAL
USA300_FPR3757 DMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRAL
************************************************************
COL NEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFHEKVIEGYQEIIHNES
N315 NEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFHEKVIEGYQEIIHNES
NCTC8325 NEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFHEKVIEGYQEIIHNES
Newman NEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFHEKVIEGYQEIIHNES
USA300_FPR3757 NEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFHEKVIEGYQEIIHNES
************************************************************
COL QRFKSVNADQPLENVVEDTYQTIIKYLEKI
N315 QRFKSVNADQPLENVVEDTYQTIIKYLEKI
NCTC8325 QRFKSVNADQPLENVVEDTYQTIIKYLEKI
Newman QRFKSVNADQPLENVVEDTYQTIIKYLEKI
USA300_FPR3757 QRFKSVNADQPLENVVEDTYQTIIKYLEKI
******************************
- ↑ Masayo Kotaka, Balvinder Dhaliwal, Jingshan Ren, Charles E Nichols, Richard Angell, Michael Lockyer, Alastair R Hawkins, David K Stammers
Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding.
Protein Sci: 2006, 15(4);774-84
[PubMed:16522804] [WorldCat.org] [DOI] (P p)