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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002155000
- symbol?: zagA
- synonym:
- description?: GTP-binding protein
- GTP-binding protein
- cobalamin synthesis protein
- cobalamin synthesis protein, putative
- putative cobalamin synthesis protein
- Putative GTPases (G3E family)
- cobalamin (vitamin B12) biosynthesis protein
- cobalamin synthesis protein, P47K
- cobalamin synthesis protein P47K
- cobW/HypB/UreG, nucleotide-binding domain protein
- CobW/P47K family protein
- Low-affinity zinc transport protein
- putative metal chaperone, GTPase
- YciC protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2665120..2666322
- synteny block?: BlockID0014590
- occurrence?: in 100% of 34 strains
zagA (yciC) : metalloprotein target prioritization zinc shuttle protein [1]
Under conditions of low zinc availability, ZagA shuttles zinc between metalloproteins to prioritize metallation of essential enzymes.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0426
08BA02176:
C248_0501
11819-97:
MS7_0424
6850:
RSAU_000380
71193:
ST398NM01_0517
ECT-R 2:
ECTR2_385
ED133:
SAOV_0466
ED98:
SAAV_0394
HO 5096 0412:
SAEMRSA15_03750
JH1:
SaurJH1_0485
JH9:
SaurJH9_0473
JKD6008:
SAA6008_00453 (cobW)
JKD6159:
SAA6159_00402 (cobW)
LGA251:
SARLGA251_03850
M013:
M013TW_0413
MRSA252:
SAR0450
MSHR1132:
SAMSHR1132_03960
MSSA476:
SAS0408
Mu3:
SAHV_0448
Mu50:
SAV0450
MW2:
MW0406
RF122:
SAB0401
ST398:
SAPIG0517
T0131:
SAT0131_00488
TCH60:
HMPREF0772_10072
TW20:
SATW20_05190
USA300_TCH1516:
USA300HOU_0452 (cobW1)
VC40:
SAVC_01845
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 | |
| JSNZ |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAKIPVTVLSGYLGSGKTTLLNHILQNREGRRIAVIVNDMSEVNIDKDLVADGGGLSRTD
N315 MAKIPVTVLSGYLGSGKTTLLNHILQNREGRRIAVIVNDMSEVNIDKDLVADGGGLSRTD
NCTC8325 MAKIPVTVLSGYLGSGKTTLLNHILQNREGRRIAVIVNDMSEVNIDKDLVADGGGLSRTD
Newman MAKIPVTVLSGYLGSGKTTLLNHILQNREGRRIAVIVNDMSEVNIDKDLVADGGGLSRTD
USA300_FPR3757 MAKIPVTVLSGYLGSGKTTLLNHILQNREGRRIAVIVNDMSEVNIDKDLVADGGGLSRTD
************************************************************
COL EKLVELSNGCICCTLRDDLLKEVERLVKKGGIDQIVIESTGISEPVPVAQTFSYIDDELG
N315 EKLVELSNGCICCTLRDDLLKEVERLVKKGGIDQIVIESTGISEPVPVAQTFSYIDDELG
NCTC8325 EKLVELSNGCICCTLRDDLLKEVERLVKKGGIDQIVIESTGISEPVPVAQTFSYIDDELG
Newman EKLVELSNGCICCTLRDDLLKEVERLVKKGGIDQIVIESTGISEPVPVAQTFSYIDDELG
USA300_FPR3757 EKLVELSNGCICCTLRDDLLKEVERLVKKGGIDQIVIESTGISEPVPVAQTFSYIDDELG
************************************************************
COL IDLTAICRLDTMVTVVDANRFVHDINSEDLLMDRDQSVDETDERSIADLLIDQVEFCDVL
N315 IDLTAICRLDTMVTVVDANRFVHDINSEDLLMDRDQSVDETDERSIADLLIDQVEFCDVL
NCTC8325 IDLTAICRLDTMVTVVDANRFVHDINSEDLLMDRDQSVDETDERSIADLLIDQVEFCDVL
Newman IDLTAICRLDTMVTVVDANRFVHDINSEDLLMDRDQSVDETDERSIADLLIDQVEFCDVL
USA300_FPR3757 IDLTAICRLDTMVTVVDANRFVHDINSEDLLMDRDQSVDETDERSIADLLIDQVEFCDVL
************************************************************
COL IINKIDLISEEELAKLEKMLSALQPTAKIIKTTNSEVDLKEVLNTQRFDFEKASESAGWI
N315 IINKIDLISEEELAKLEKVLSALQPIAKIIKTTNSEVDLKEVLNTQRFDFEKASESAGWI
NCTC8325 IINKIDLISEEELAKLEKMLSALQPTAKIIKTTNSEVDLKEVLNTQRFDFEKASESAGWI
Newman IINKIDLISEEELAKLEKMLSALQPTAKIIKTTNSEVDLKEVLNTQRFDFEKASESAGWI
USA300_FPR3757 IINKIDLISEEELAKLEKMLSALQPTAKIIKTTNSEVDLKEVLNTQRFDFEKASESAGWI
******************:****** **********************************
COL KELESGGHASHTPETEEYGISSFVYKRRLPFHAKRFNDWLESMPNNVVRSKGIVWLAQYN
N315 KELESGGHASHTPETEEYGISSFVYKRRLPFHAKRFNDWLESMSNNVVRSKGIVWLAQYN
NCTC8325 KELESGGHASHTPETEEYGISSFVYKRRLPFHAKRFNDWLESMPNNVVRSKGIVWLAQYN
Newman KELESGGHASHTPETEEYGISSFVYKRRLPFHAKRFNDWLESMPNNVVRSKGIVWLAQYN
USA300_FPR3757 KELESGGHASHTPETEEYGISSFVYKRRLPFHAKRFNDWLESMPNNVVRSKGIVWLAQYN
*******************************************.****************
COL HVACLLSQAGSSCNIHPVTYWVASMSEAQQTQILAERQDVAAEWDPEYGDRHTQFVIIGT
N315 HVACLLSQAGSSCNIHPVTYWVASMSEAQQTQILAERQDVAAEWDPEYGDRHTQFVIIGT
NCTC8325 HVACLLSQAGSSCNIHPVTYWVASMSEAQQTQILAERQDVAAEWDPEYGDRHTQFVIIGT
Newman HVACLLSQAGSSCNIHPVTYWVASMSEAQQTQILAERQDVAAEWDPEYGDRHTQFVIIGT
USA300_FPR3757 HVACLLSQAGSSCNIHPVTYWVASMSEAQQTQILAERQDVAAEWDPEYGDRHTQFVIIGT
************************************************************
COL ELDEEKLTKELDACLVNAQEIDADWQQFEDPYQWQIRPAR
N315 ELDEEKLTKELDACLVNAQEIDADWQQFEDPYQWQIRPAR
NCTC8325 ELDEEKLTKELDACLVNAQEIDADWQQFEDPYQWQIRPAR
Newman ELDEEKLTKELDACLVNAQEIDADWQQFEDPYQWQIRPAR
USA300_FPR3757 ELDEEKLTKELDACLVNAQEIDADWQQFEDPYQWQIRPAR
****************************************
- ↑ Matthew R Jordan, Jiefei Wang, Andy Weiss, Eric P Skaar, Daiana A Capdevila, David P Giedroc
Mechanistic Insights into the Metal-Dependent Activation of Zn II-Dependent Metallochaperones.
Inorg Chem: 2019, 58(20);13661-13672
[PubMed:31247880] [WorldCat.org] [DOI] (I p)