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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002142000
- symbol?: lpl3
- synonym:
- description?: tandem-type lipoprotein
- tandem-type lipoprotein
- tandem lipoprotein
- staphylococcal tandem lipoprotein
- lipoprotein
- Membrane lipoprotein
- pseudogene
- staphylococcus tandem lipoproteins family protein
- Tandem lipoprotein within Pathogenicity island
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2644134..2645795
- synteny block?: BlockID0014480
- occurrence?: in 56% of 34 strains
tilA (lpl) : tandem TslA phospholipase immunity lipoprotein paralogue [1]
• This locus is highly prone to recombination leading to gene duplication / loss. Gene nomenclature is confusing and appears to be numbered sequentially by position in the genome and is not intended to show homology between strains (e.g. the first instance of tilA/lpl in COL may have the greatest homology with the sixth instance in FPR3757 but the gene names would still be different [i.e. tilA1/lpl1 and tilA6/lpl6 in COL and FPR3757, respectively]). Likewise, pseudogenes are frequent and assigned gene nomenclature in this locus. As appropriate, please append a numeral to the gene names provided here consistent with the number of gene duplications in your genome of interest.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0419 (lpl7)
08BA02176:
C248_0493
11819-97:
—
6850:
RSAU_000374
71193:
ST398NM01_0509
ECT-R 2:
ECTR2_378
ED133:
—
ED98:
SAAV_0386
HO 5096 0412:
—
JH1:
SaurJH1_0478
JH9:
SaurJH9_0466
JKD6008:
SAA6008_00441
JKD6159:
—
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
—
Mu3:
SAHV_0441 (lpl7)
Mu50:
SAV0443 (lpl7)
MW2:
—
RF122:
—
ST398:
SAPIG0509
T0131:
SAT0131_00477 (acs)
TCH60:
—
TW20:
—
USA300_TCH1516:
USA300HOU_0441 (lpl7)
VC40:
SAVC_01810
⊟Genome Viewer[edit | edit source]
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
N315 ----------MGYFKRVVLYIIVMVVSVFIIGCNKSSDTSEKPKEDSKETQIKKSFAKTL
NCTC8325 MKYKTERREAMGYLKRFALYISVMILIFAIAGCGKGNET----KEDSKEEQIKKSFAKTL
Newman ---------MMGYLKRLVLYIVIMVMSVFIIGCDKSSDTAEKSKEDSKETQIKKSFAKTL
USA300_FPR3757 ---------MMGYLKRLVLYIVIMVMSVFIIGCDKSSDTAEKSKEDSKETQIKKSFAKTL
***:**..*** :*:: . * **.*..:* ****** **********
N315 DMYPIKNLEDLYDKEGYRDGEFKKGDKGMWTIYTDFAKSNKQGGLSNEGMVLYLDRNTRT
NCTC8325 DMYPIKNLEDLYDKEGYRDGEFKKGDKGMWTIYTDFAKSNKQGGLSNEGMVLYLDRNTRT
Newman DMYSIKNLEELYDKEGYRDGEFEKGDKGMWTIYTDFAKSNKQGELSNEGMVLYLDRNTRT
USA300_FPR3757 DMYSIKNLEELYDKEGYRDGEFEKGDKGMWTIYTDFAKSNKPGELSNEGMVLYLDRNTRT
***.*****:************:****************** * ****************
N315 AKGHYFVKTFYNKGKFPDRKNYKVEMKNNKIILLDKVEDINLKKRIENFKFFGQYANLKE
NCTC8325 AKGHYFVKTFYNKGKFPDRKNYKVEMKNNKIILLDKVEDTNLKKRIENFKFFGQYANLKE
Newman AKGYYFVRTFYRKDKLPDRKNYKVEMKNNKIILLDKVEDKKLKQKIENFKFFSQYANLKE
USA300_FPR3757 AKGYYFVRTFYRKDKLPDRKNYKVEMKNNKIILLDKVEDKKLKQKIENFKFFSQYANLKE
***:***:***.*.*:*********************** :**::*******.*******
N315 LKNYSNGDVSINENVPSYDAKFKMSNKDENVKQLRSRYNIPTDKAPVLKMHIDGDLKGSS
NCTC8325 LKNYNNGDVSINENVPSYDAKFKMSNKDENVKQLRSRYNIPTDKAPVLKMHIDGNLKGSS
Newman LKNYSNGDVSINENVPSYDVKYKMSNKDENVKQLRSRYNIPTDKSPVLKMHIDGNLKGSS
USA300_FPR3757 LKNYSNGDVSINENVPSYDVKYKMSNKDENVKQLRSRYNIPTDKSPVLKMHIDGNLKGSS
****.**************.*:**********************:*********:*****
N315 VGYKKLEIDFSKGEKSDLSVIDSLNFQPAKVDEDDE
NCTC8325 VGYKKLEIDFSKGGKSDLSVIDSLNFQPAKVDEDDE
Newman VGDRKLEIDFSKRENSHLSVIDSLDYQPAKTNKDDE
USA300_FPR3757 VGDRKLEIDFSKRENSHLSVIDSLDYQPAKTNKDDE
** :******** :*.*******::****.::***
- ↑ Stephen R Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement.
Nat Commun: 2023, 14(1);8438
[PubMed:38114483] [WorldCat.org] [DOI] (I e)Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
Microb Genom: 2022, 8(8);
[PubMed:35960642] [WorldCat.org] [DOI] (I p)