⊟Summary[edit | edit source]
- pan ID?: SAUPAN002141000
- symbol?: lpl4
- synonym:
- description?: tandem-type lipoprotein
- tandem-type lipoprotein
- tandem lipoprotein
- staphylococcal tandem lipoprotein
- Tandem lipoprotein within Pathogenicity island
- lipoprotein
- putative lipoprotein
- staphylococcus tandem lipoproteins family protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2643713..2644722
- synteny block?: BlockID0014470
- occurrence?: in 41% of 34 strains
tilA (lpl) : tandem TslA phospholipase immunity lipoprotein paralogue [1]
• This locus is highly prone to recombination leading to gene duplication / loss. Gene nomenclature is confusing and appears to be numbered sequentially by position in the genome and is not intended to show homology between strains (e.g. the first instance of tilA/lpl in COL may have the greatest homology with the sixth instance in FPR3757 but the gene names would still be different [i.e. tilA1/lpl1 and tilA6/lpl6 in COL and FPR3757, respectively]). Likewise, pseudogenes are frequent and assigned gene nomenclature in this locus. As appropriate, please append a numeral to the gene names provided here consistent with the number of gene duplications in your genome of interest.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKYKTERREAMGYLKRFALYISVMILIFAIAGCGKGNETKEDSKEEQIKKSFAKTLDMYP
N315 ----------MRDSKRVVLYISIMVLSIFIIGCGKGNEIKEDAKEEQIKKSFAKTLDMYP
Newman ----------MKSIKRIGLCISLLILSIFVTSCDGDNKITGDSKETQNQKSFSKTLDMYP
USA300_FPR3757 ----------MKSIKRIGLCISLLILSIFVTSCDGDNKITGDSKETQIKKSFSKTLDMYP
* **. * **:::* : : .*. .*: . *:** * :***:*******
COL IKNLEDLYDKEGYRDGEFKKGDKGMWTIYTDFAKGNKSDELDDEGMVLNLDRNTRTAKGY
N315 IKNLEDLYDKEGYRDGEFKKGDKGMWTIYTDFAKSNRPGVLDNEGMVLNLDRNTRTAKGY
Newman IKNLEDLYDKEGYRDGEFKKGDKGMWTIYTDFAKGNKSDELDDEGMVLNLDRNTRTAKGY
USA300_FPR3757 IKNLEDLYDKEGYRDGEFKKGDKGMWTIYTDFAKGNKSDELDDEGMVLNLDRNTRTAKGY
**********************************.*:.. **:*****************
COL YFVKKFYEKDKLPDRKNYKVEMKNNKIILLDKVEDPNLKKRIENFKFFGQYANFKDLENY
N315 YFVDTIYDNHENSYSKNYRVEMKNNKIILLDKVEDQKLKERIENFKFFGQYADFKSLKSY
Newman YFVKKFYEKDKLPDRKNYKVEMKNNKIILLDKVEDPNLKKRIENFKFFGQYANFKDLENY
USA300_FPR3757 YFVKKFYEKDKLPDRKNYKVEMKNNKIILLDKVEDPNLKKRIENFKFFGQYANFKDLENY
***..:*::.: . ***:**************** :**:************:**.*:.*
COL NNGDVSINWNVPSYDVEYKMSNKDENVKQLRSRYNIPTDKAPMLKMHIDGDLKGSSVGYK
N315 NHGDVSINSNVPSYDAKFKMSNKDENVKQLRSRYNIPTDKAPILKMHIDGDLKGSSVGYK
Newman NNGDVSINWNVPSYDVEYKMSNKDENVKQLRSRYNIPTDKAPMLKMHIDGDLKGSSVGYK
USA300_FPR3757 NNGDVSINWNVPSYDVEYKMSNKDENVKQLRSRYNIPTEKAPMLKMHIDGDLKGSSVGYK
*:****** ******.::********************:***:*****************
COL RLEIDFSK-EGRDISVIDYLSYKPAKK----
N315 KLEIDFSKEENSELSIVDSLNFQPAKNKDDE
Newman RLEIDFSK-EGRDISVIDYLSYKPAKK----
USA300_FPR3757 RLEIDFSK-EGRDISVIDYLSYKPAKK----
:******* *. ::*::* *.::***:
- ↑ Stephen R Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement.
Nat Commun: 2023, 14(1);8438
[PubMed:38114483] [WorldCat.org] [DOI] (I e)Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
Microb Genom: 2022, 8(8);
[PubMed:35960642] [WorldCat.org] [DOI] (I p)