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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002140000
- symbol?: lpl6
- synonym:
- description?: tandem-type lipoprotein
- tandem-type lipoprotein
- tandem lipoprotein
- lipoprotein, putative
- staphyloccoccus tandem lipoprotein
- pseudogene
- putative lipoprotein
- staphylococcus tandem lipoproteins family protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2642891..2643652
- synteny block?: BlockID0014460
- occurrence?: in 50% of 34 strains
tilA (lpl) : tandem TslA phospholipase immunity lipoprotein paralogue [1]
• This locus is highly prone to recombination leading to gene duplication / loss. Gene nomenclature is confusing and appears to be numbered sequentially by position in the genome and is not intended to show homology between strains (e.g. the first instance of tilA/lpl in COL may have the greatest homology with the sixth instance in FPR3757 but the gene names would still be different [i.e. tilA1/lpl1 and tilA6/lpl6 in COL and FPR3757, respectively]). Likewise, pseudogenes are frequent and assigned gene nomenclature in this locus. As appropriate, please append a numeral to the gene names provided here consistent with the number of gene duplications in your genome of interest.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0415
08BA02176:
—
11819-97:
—
6850:
RSAU_000370
71193:
—
ECT-R 2:
ECTR2_374
ED133:
—
ED98:
SAAV_0382
HO 5096 0412:
SAEMRSA15_03690
JH1:
SaurJH1_0474
JH9:
SaurJH9_0462
JKD6008:
—
JKD6159:
—
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
SAS0402
Mu3:
SAHV_0437
Mu50:
SAV0439
MW2:
MW0400 (lpl13)
RF122:
—
ST398:
—
T0131:
—
TCH60:
—
TW20:
—
USA300_TCH1516:
USA300HOU_0444
VC40:
—
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| Newman | |
| USA300_FPR3757 | |
| JSNZ |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
COL MKCFQKL--YIFILILIVLMAGC-ESNKITGDSKETQIKKSFAKTLDVYPTKNLEDFYDK
N315 ------------------------------------------------------------
Newman MKCFQKL--YIFILILIVLMAGC-ESNKITGDSKETQIKKSFAKTLDVYPTKNLEDFYDK
USA300_FPR3757 MKCFQKL--YIFILILIVLMAGC-ESNKITGDSKETQIKKSFAKTLDVYPTKNLEDFYDK
JSNZ MGYLKRLSWYISILFLIVVIAGCGKGDDTKEDSKEQQIKKSFAKTLDMYPNENLEDFYDK
COL EGYRDGEFKKGDKGKWVIRSEMTTELKNENMVSKGMVIRLNRNSRTCTGEYFVRIVKEDS
N315 ---------------------------------------MNRNTRTTTGYFSIEEIDSRK
Newman EGYRDGEFKKGDKGKWVIRSEMTTELKNENMVSKGMVIRLNRNSRTCTGEYFVRIVKEDS
USA300_FPR3757 EGYRDGEFKKGDKGKWVIRSEMTTELKNENMVSKGMVIRLNRNSRTCTGEYFVRIVKEDS
JSNZ EGYRDGEFKKDDKGTWLIRSEIVKQPKGKVMKTRGMQLYINRNTKTAKGFFVLKEISENN
:***::* .* : :. :.. .
COL EGKVYSDERKYPVKMENNKIITLKPIDDEKVKKEIEEFKFFVQYGNFKELENYKDGEVTY
N315 SLDERETEKKYPVKMINNKIIPTEEIKDEKLKKEIENFKFFVQYGSFKGIENYENGDISY
Newman EGKVYSDERKYPVKMENNKIITLKPIDDEKVKKEIEEFKFFVQYGNFKELENYKDGEVTY
USA300_FPR3757 EGKVYSDERKYPVKMENNKIITLKPIDDEKVKKEIEEFKFFVQYGNFKELENYKDGEVTY
JSNZ NRVNKDKEEKYEVKMVGNKIIPTEQINDEKIKKEIENFKFFVQYGNFKNFEKYKNGEFSY
. . *.** *** .****. : *.***:*****:********.** :*:*::*:.:*
COL NPEAPIYSAQYQLKNSDYNVEQLRKRYNITTKKAPKLLLKGSGNLKGSSVGYKNIEFTFV
N315 NSEAPIYSAKYKLKNDDYNVKELRKRYNIPTEKAPKLLLKGSGDLKGSSVGYKEIEFIFI
Newman NPEAPIYSAQYQLKNSDYNVEQLRKRYNITTKKAPKLLLKGSGNLKGSSVGYKNIEFTFV
USA300_FPR3757 NPEAPIYSAQYQLKNSDYNVEQLRKRYNITTKKAPKLLLKGSGNLKGSSVGYKNIEFTFV
JSNZ NPEAPIYSAKYQLQNDDYNVRQLRKIYDISTKEAPKLLLKSGGDLKGSSVGQKDIEFTFV
*.*******:*:*:*.****.:*** *:*.*::*******..*:******* *:*** *:
COL ENKEENIYFTDSINFNPSEDK
N315 ENKKENIYFSDGLNLIPSD--
Newman ENKEENIYFTDSINFNPSEDK
USA300_FPR3757 ENKEENIYFTDSINFNPSEDK
JSNZ ERKGENIYFNDSVEFIPSK--
*.* *****.*.::: **.
- ↑ Stephen R Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement.
Nat Commun: 2023, 14(1);8438
[PubMed:38114483] [WorldCat.org] [DOI] (I e)Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
Microb Genom: 2022, 8(8);
[PubMed:35960642] [WorldCat.org] [DOI] (I p)