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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002135000
- symbol?: lpl9
- synonym:
- description?: tandem-type lipoprotein
- tandem-type lipoprotein
- tandem lipoprotein
- staphylococcal tandem lipoprotein
- Membrane lipoprotein
- putative lipoprotein
- staphylococcus tandem lipoprotein
- staphylococcus tandem lipoproteins family protein
- Tandem lipoprotein within Pathogenicity island 2
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2627167..2627949
- synteny block?: BlockID0014410
- occurrence?: in 76% of 34 strains
tilA (lpl) : tandem TslA phospholipase immunity lipoprotein paralogue [1]
• This locus is highly prone to recombination leading to gene duplication / loss. Gene nomenclature is confusing and appears to be numbered sequentially by position in the genome and is not intended to show homology between strains (e.g. the first instance of tilA/lpl in COL may have the greatest homology with the sixth instance in FPR3757 but the gene names would still be different [i.e. tilA1/lpl1 and tilA6/lpl6 in COL and FPR3757, respectively]). Likewise, pseudogenes are frequent and assigned gene nomenclature in this locus. As appropriate, please append a numeral to the gene names provided here consistent with the number of gene duplications in your genome of interest.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0413 (lpl2)
08BA02176:
C248_0488
11819-97:
MS7_0411
6850:
RSAU_000368
71193:
ST398NM01_0504
ECT-R 2:
ECTR2_372
ED133:
—
ED98:
SAAV_0380
HO 5096 0412:
SAEMRSA15_03660
JH1:
SaurJH1_0472
JH9:
SaurJH9_0460
JKD6008:
SAA6008_00448 (lpl2)
JKD6159:
—
JSNZ:
—
LGA251:
SARLGA251_03740
M013:
—
MRSA252:
SAR0438
MSHR1132:
—
MSSA476:
—
Mu3:
SAHV_0435 (lpl2)
Mu50:
SAV0437 (lpl2)
MW2:
—
RF122:
—
ST398:
SAPIG0504
T0131:
SAT0131_00483
TCH60:
HMPREF0772_10081
TW20:
SATW20_05140
USA300_TCH1516:
USA300HOU_0447
VC40:
SAVC_01820
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MMEYIKKIALYMSVLLLIIFIGGCGNMKDEQKKEEQTNKTDSKEEQIKKSFAKTLDMYPI
N315 -MGYLKKLALFISVIILGIFIIGCDSSSDTAEKA----KEDSKEEQIKKSFAKTLDMYPI
NCTC8325 --------------------------MKDEQKKEEQTNKTDSKEEQIKKSFAKTLDMYPI
Newman -MEYIKKIALYMSVLLLIIFIGGCGNMKDEQKKEEQTNKTDSKEEQIKKSFAKTLDMYPI
USA300_FPR3757 -MEYIKKIALYMSVLLLIIFIGGCGNMKDEQKKEEQTNKTDSKEEQIKKSFAKTLDMYPI
.* :* * ********************
COL KNLEDLYDKEGYRDGEFKKGDKGTWTILTGFSKSNKPGVLDDEGMVLYLNRNTKKATGYY
N315 KNLEDLYDKEGYRDGEFKKGDKGTWTLLTSFSKSNKPGEIDDEGMVLYLNRNTKKATGYY
NCTC8325 KNLEDLYDKEGYRDGEFKKGDKGTWTILTGFSKSNKPGVLDDEGMVLYLNRNTKKATGYY
Newman KNLEDLYDKEGYRDGEFKKGDKGTWTILTGFSKSNKPGVLDDEGMVLYLNRNTKKATGYY
USA300_FPR3757 KNLEDLYDKEGYRDGEFKKGDKGTWTILTGFSKSNKPGVLDDEGMVLYLNRNAKKATGYY
**************************:**.******** :************:*******
COL FVNKVYDDISKNHNEKKYRVELKNNKIVLLDNVEDKKLKQKIENFKFFSQYADFKDLKNY
N315 FVNKIYDDISKNQNEKKYRVELKNNKIILLDNVEDEKLKQKIENFKFFSQYADFKDLKNY
NCTC8325 FVNKVYDDISKNHNEKKYRVELKNNKIVLLDNVEDKKLKQKIENFKFFSQYADFKDLKNY
Newman FVNKVYDDISKNHNEKKYRVELKNNKIVLLDNVEDKKLKQKIENFKFFSQYADFKDLKNY
USA300_FPR3757 FVNKVYDDISKNHNEKKYRVELKNNKIVLLDNVEDKKLKQKIENFKFFSQYADFKDLKNY
****:*******:**************:*******:************************
COL QDGNITTNENVPSYEAQYKMNNSDKNVKKLREIYPITTNNSPNLKLYIDGDIKGSSVGYK
N315 QDGSITTNENVPRYEAEYKLNNSDTNVKKLRDIYPITTKKAPILKLHIDGDIKGSSVGYK
NCTC8325 QDGNITTNENVPSYEAQYKMNNSDKNVKKLREIYPITTNNSPNLKLYIDGDIKGSSVGYK
Newman QDGNITTNENVPSYEAQYKMNNSDKNVKKLREIYPITTNNSPNLKLYIDGDIKGSSVGYK
USA300_FPR3757 QDGNITTNENVPSYEAQYKMNNSDKNVKKLREIYPITTNNSPNLKLYIDGDIKGSSVGYK
***.******** ***:**:****.******:******:::* ***:*************
COL KIEYKFSKDKGQETTLRDYLNFGPSEGENVE
N315 KIEYKFSKVKDQETTLRDYLNFGPSDEDS--
NCTC8325 KIEYKFSKDKGQETTLRDYLNFGPSEGENVE
Newman KIEYKFSKDKGQETTLRDYLNFGPSEGENVE
USA300_FPR3757 KIEYKFSKDKGQETTLRDYLNFGPSEGENVE
******** *.**************: :.
- ↑ Stephen R Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement.
Nat Commun: 2023, 14(1);8438
[PubMed:38114483] [WorldCat.org] [DOI] (I e)Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
Microb Genom: 2022, 8(8);
[PubMed:35960642] [WorldCat.org] [DOI] (I p)