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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001982000
- symbol?: ahpC
- synonym:
- description?: alkyl hydroperoxide reductase subunit C
- alkyl hydroperoxide reductase subunit C
- alkyl hydroperoxide reductase
- alkyl hydroperoxide reductase, subunit C
- peroxiredoxin
- Alkyl hydroperoxide reductase protein C
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 2449604..2450173
- synteny block?: BlockID0013350
- occurrence?: in 100% of 34 strains
ahpC : alkyl hydroperoxide reductase subunit C [1]
Staphylococci have two general strategies to deal with peroxide stresses. Alkyl hydroperoxide reductases are effective at managing basal peroxide levels produced as side products of normal metabolism. Sudden spikes of peroxides experienced during host infection are more effectively managed by catalases, although AHRs do continue to play a role in managing host-derived oxidative stresses.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0380 (ahpC)
08BA02176:
C248_0437 (ahpC)
11819-97:
MS7_0371 (ahpC)
6850:
RSAU_000324 (ahpC)
71193:
ST398NM01_0458
ECT-R 2:
ECTR2_341 (ahpC)
ED133:
SAOV_0404c (ahpC)
ED98:
SAAV_0348 (ahpC)
HO 5096 0412:
SAEMRSA15_03340 (ahpC)
JH1:
SaurJH1_0440
JH9:
SaurJH9_0429
JKD6008:
SAA6008_00381 (ahpC)
JKD6159:
SAA6159_00356 (ahpC)
JSNZ:
JSNZ_000336 (ahpC)
LGA251:
SARLGA251_03420 (ahpC)
M013:
M013TW_0361
MRSA252:
SAR0399 (ahpC)
MSHR1132:
SAMSHR1132_03530
MSSA476:
SAS0358
Mu3:
SAHV_0378 (ahpC)
Mu50:
SAV0381 (ahpC)
MW2:
MW0357 (ahpC)
RF122:
SAB0331c (ahpC)
ST398:
SAPIG0458 (ahpC)
T0131:
SAT0131_00414 (adhE)
TCH60:
HMPREF0772_10114 (ahpC)
TW20:
SATW20_04480 (ahpC)
USA300_TCH1516:
USA300HOU_0404 (ahpC1)
VC40:
SAVC_01660
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQY
N315 MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQY
NCTC8325 MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQY
Newman MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQY
USA300_FPR3757 MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQY
************************************************************
COL EELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLA
N315 EELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLA
NCTC8325 EELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLA
Newman EELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLA
USA300_FPR3757 EELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLA
************************************************************
COL QRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ
N315 QRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ
NCTC8325 QRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ
Newman QRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ
USA300_FPR3757 QRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ
************************************************************
COL PGLDLVGKI
N315 PGLDLVGKI
NCTC8325 PGLDLVGKI
Newman PGLDLVGKI
USA300_FPR3757 PGLDLVGKI
*********
- ↑ L Armstrong-Buisseret, M B Cole, G S Stewart
A homologue to the Escherichia coli alkyl hydroperoxide reductase AhpC is induced by osmotic upshock in Staphylococcus aureus.
Microbiology (Reading): 1995, 141 ( Pt 7);1655-61
[PubMed:7551034] [WorldCat.org] [DOI] (P p)M J Horsburgh, M O Clements, H Crossley, E Ingham, S J Foster
PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus.
Infect Immun: 2001, 69(6);3744-54
[PubMed:11349039] [WorldCat.org] [DOI] (P p)Kate Cosgrove, Graham Coutts, Ing-Marie Jonsson, Andrej Tarkowski, John F Kokai-Kun, James J Mond, Simon J Foster
Catalase (KatA) and alkyl hydroperoxide reductase (AhpC) have compensatory roles in peroxide stress resistance and are required for survival, persistence, and nasal colonization in Staphylococcus aureus.
J Bacteriol: 2007, 189(3);1025-35
[PubMed:17114262] [WorldCat.org] [DOI] (P p)