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⊟Summary[edit | edit source]

  • pan ID?: SAUPAN001981000
  • symbol?: ahpF
  • synonym:
  • description?: alkyl hydroperoxide reductase subunit F

      descriptions from strain specific annotations:

    • alkyl hydroperoxide reductase subunit F
    • alkyl hydroperoxide reductase
    • alkyl hydroperoxide reductase, subunit F
    • Alkyl hydroperoxide reductase protein F
    • alkyl hydroperoxide reductase, F subunit
    • alkyl hydroperoxide reductase, large subunit
    • NADH oxidase H2O2-forming
  • strand?: -
  • coordinates?: 2448065..2449588
  • synteny block?: BlockID0013340
  • occurrence?: in 100% of 34 strains

ahpF : alkyl hydroperoxide reductase subunit F [1]

Staphylococci have two general strategies to deal with peroxide stresses. Alkyl hydroperoxide reductases are effective at managing basal peroxide levels produced as side products of normal metabolism. Sudden spikes of peroxides experienced during host infection are more effectively managed by catalases, although AHRs do continue to play a role in managing host-derived oxidative stresses.

⊟Orthologs[edit | edit source]

    COL:
    SACOL0451 (ahpF)
    N315:
    SA0365 (ahpF)
    NCTC8325:
    SAOUHSC_00364
    Newman:
    NWMN_0371 (ahpF)
    USA300_FPR3757:
    SAUSA300_0379 (ahpF)
    04-02981:
    SA2981_0379 (ahpF)
    08BA02176:
    C248_0436 (ahpF)
    11819-97:
    MS7_0370 (ahpF)
    6850:
    RSAU_000323 (ahpF)
    71193:
    ST398NM01_0457
    ECT-R 2:
    ECTR2_340 (ahpF)
    ED133:
    SAOV_0403c (ahpF)
    ED98:
    SAAV_0347 (ahpF)
    HO 5096 0412:
    SAEMRSA15_03330 (ahpF)
    JH1:
    SaurJH1_0439
    JH9:
    SaurJH9_0428
    JKD6008:
    SAA6008_00380 (ahpF)
    JKD6159:
    SAA6159_00355 (ahpF)
    JSNZ:
    JSNZ_000335 (ahpF)
    LGA251:
    SARLGA251_03410 (ahpF)
    M013:
    M013TW_0360
    MRSA252:
    SAR0398 (ahpF)
    MSHR1132:
    SAMSHR1132_03520
    MSSA476:
    SAS0357
    Mu3:
    SAHV_0377 (ahpF)
    Mu50:
    SAV0380 (ahpF)
    MW2:
    MW0356 (ahpF)
    RF122:
    SAB0330c (ahpF)
    ST398:
    SAPIG0457 (ahpF)
    T0131:
    SAT0131_00413
    TCH60:
    HMPREF0772_10115 (ahpF)
    TW20:
    SATW20_04470 (ahpF)
    USA300_TCH1516:
    USA300HOU_0403 (ahpF)
    VC40:
    SAVC_01655

⊟Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MLNADLKQQLKQLLELMEGNVEFVASLGSDDKSKELKDLLTEITDMSPRLSLSEKSLKRT
    N315            MLNADLKQQLKQLLELMEGNVEFVASLGSDEKSKELKELLTEISDMSPRLSLSEKSLKRT
    NCTC8325        MLNADLKQQLKQLLELMEGNVEFVASLGSDDKSKELKDLLTEITDMSPRLSLSEKSLKRT
    Newman          MLNADLKQQLKQLLELMEGNVEFVASLGSDDKSKELKDLLTEITDMSPRLSLSEKSLKRT
    USA300_FPR3757  MLNADLKQQLKQLLELMEGNVEFVASLGSDDKSKELKDLLTEITDMSPRLSLSEKSLKRT
                    ******************************:******:*****:****************

    COL             PSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKKLEGSFHFE
    N315            PSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKNLEGSFHFE
    NCTC8325        PSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKKLEGSFHFE
    Newman          PSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKKLEGSFHFE
    USA300_FPR3757  PSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIGQIKKLEGSFHFE
                    ***********************************************.***:********

    COL             TFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNG
    N315            TFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNG
    NCTC8325        TFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNG
    Newman          TFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNG
    USA300_FPR3757  TFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNG
                    ************************************************************

    COL             RMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGG
    N315            RMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGG
    NCTC8325        RMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGG
    Newman          RMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGG
    USA300_FPR3757  RMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGG
                    ************************************************************

    COL             QVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENG
    N315            QVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENG
    NCTC8325        QVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENG
    Newman          QVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENG
    USA300_FPR3757  QVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENG
                    ************************************************************

    COL             AVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEA
    N315            AVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEA
    NCTC8325        AVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEA
    Newman          AVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEA
    USA300_FPR3757  AVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEA
                    ************************************************************

    COL             AIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYED
    N315            AIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYED
    NCTC8325        AIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYED
    Newman          AIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYED
    USA300_FPR3757  AIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYED
                    ************************************************************

    COL             MNTGEEHLLNLDGIFVQIGLLPNTSWLNDAVELNERGEIVIDRNNNTNVPGIFAAGDVTD
    N315            MSTGEEHLLNLDGIFVQIGLLPNTSWLKDAVELNERGEIVIDRNNNTNVPGIFAAGDVTD
    NCTC8325        MNTGEEHLLNLDGIFVQIGLLPNTSWLNDAVELNERGEIVIDRNNNTNVPGIFAAGDVTD
    Newman          MNTGEEHLLNLDGIFVQIGLLPNTSWLNDAVELNERGEIVIDRNNNTNVPGIFAAGDVTD
    USA300_FPR3757  MNTGEEHLLNLDGIFVQIGLLPNTSWLNDAVELNERGEIVIDRNNNTNVPGIFAAGDVTD
                    *.*************************:********************************

    COL             QKNKQIIISMGAGANAALNAFDYIIRN
    N315            QKNKQIIISMGAGANAALNAFDYIIRN
    NCTC8325        QKNKQIIISMGAGANAALNAFDYIIRN
    Newman          QKNKQIIISMGAGANAALNAFDYIIRN
    USA300_FPR3757  QKNKQIIISMGAGANAALNAFDYIIRN
                    ***************************

  1. ↑ L Armstrong-Buisseret, M B Cole, G S Stewart
    A homologue to the Escherichia coli alkyl hydroperoxide reductase AhpC is induced by osmotic upshock in Staphylococcus aureus.
    Microbiology (Reading): 1995, 141 ( Pt 7);1655-61
    [PubMed:7551034] [WorldCat.org] [DOI] (P p)    M J Horsburgh, M O Clements, H Crossley, E Ingham, S J Foster
    PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus.
    Infect Immun: 2001, 69(6);3744-54
    [PubMed:11349039] [WorldCat.org] [DOI] (P p)    Kate Cosgrove, Graham Coutts, Ing-Marie Jonsson, Andrej Tarkowski, John F Kokai-Kun, James J Mond, Simon J Foster
    Catalase (KatA) and alkyl hydroperoxide reductase (AhpC) have compensatory roles in peroxide stress resistance and are required for survival, persistence, and nasal colonization in Staphylococcus aureus.
    J Bacteriol: 2007, 189(3);1025-35
    [PubMed:17114262] [WorldCat.org] [DOI] (P p)
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