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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001135000
- symbol?: tarL
- synonym:
- description?: CDP-glycerol glycerophosphotransferase family protein
- CDP-glycerol glycerophosphotransferase family protein
- putative teichoic acid biosynthesis protein
- teichoic acid biosynthesis protein
- teichoic acid biosynthesis protein B
- teichoic acid ribitol-phosphate polymerase TarL
- CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase
- putative CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
- Putative polyribitolphosphotransferase
- CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase family protein
- CDP-ribitol ribitolphosphotransferase
- glycosyl/glycerophosphate transferase
- teichoic acid biosynthesis protein, putative
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1404549..1406237
- synteny block?: BlockID0006550
- occurrence?: in 100% of 34 strains
tarL : extended-length ribitol-phosphate polymerase [1]
• A crystal structure is available : 8VA1
- Wall teichoic acid biosynthesis in Staphylococcus aureus is complicated by the presence of multiple overlapping pathways that are at least situationally functionally redundant. Initial steps involve modification of undecaprenyl phosphate with GlcNAc (TarO) and ManNAc (TarA) and then priming with two equivalents of glycerophosphate (TarB, TarF). This makes a starter unit for two types of WTA:
- TarL can prime and polymerize approximately 40 units of ribitol phosphate resulting into extended-length teichoic acids. The CDP-ribitol substrate is generated by the TarI1 and TarJ1 enzymes
- TarK can prime and polymerize approximately 20 units of ribitol phosphate resulting into short-length teichoic acids. The CDP-ribitol substrate is generated by the TarI2 and TarJ2 enzymes
- TarJ encodes ribulose-5-phosphate reductase (alt. ribitol-5-phosphate dehydrogenase) which reduces ribulose phosphate to ribitol phosphate
- TarI encodes ribitol-5-phosphate cytidylyltransferase which activates ribitol as CDP-ribitol
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0257
08BA02176:
C248_0245
11819-97:
MS7_0247
6850:
RSAU_000201
71193:
ST398NM01_0270
ECT-R 2:
ECTR2_218
ED133:
SAOV_0196
ED98:
SAAV_0225
HO 5096 0412:
SAEMRSA15_02160
JH1:
SaurJH1_0248
JH9:
SaurJH9_0242
JKD6008:
SAA6008_00231
JKD6159:
SAA6159_00234
JSNZ:
JSNZ_000197 (tarL)
LGA251:
SARLGA251_02210 (tarL)
M013:
M013TW_0238
MRSA252:
SAR0254
MSHR1132:
SAMSHR1132_02250
MSSA476:
SAS0234
Mu3:
SAHV_0256
Mu50:
SAV0257
MW2:
MW0233
RF122:
SAB0196
ST398:
SAPIG0270
T0131:
SAT0131_00250 (udk)
TCH60:
HMPREF0772_10245
TW20:
SATW20_02590 (tarL)
USA300_TCH1516:
USA300HOU_0268 (tagB2)
VC40:
SAVC_01025
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MVKSKIYIDKIYWERVQLFVEGHSENLDLEDSNFVLRNLTETRTMKANDVKIDGNQFVCR
N315 MVKSKIYIDKIYWERVQLFVEGHSENLDLEDSNFVLRNLTETRTMKANDVKIDGNQFVCR
NCTC8325 MVKSKIYIDKIYWERVQLFVEGHSENLDLEDSNFVLRNLTETRTMKANDVKIDGNQFVCR
Newman MVKSKIYIDKIYWERVQLFVEGHSENLDLEDSNFVLRNLTETRTMKANDVKIDGNQFVCR
USA300_FPR3757 MVKSKIYIDKIYWERVQLFVEGHSENLDLEDSNFVLRNLTETRTMKANDVKIDGNQFVCR
************************************************************
COL FNVAILDNGYYLPEDKYLLVNEQELDYIAQLNPDVINDAYQNLKPEQEEEYNELETQNGK
N315 FNVAILDNGYYLPEDKYLLVNEQELDYIAQLNPDVINDAYQNLKPEQEEEYNELETQNGK
NCTC8325 FNVAILDNGYYLPEDKYLLVNEQELDYIAQLNPDVINDAYQNLKPEQEEEYNELETQNGK
Newman FNVAILDNGYYLPEDKYLLVNEQELDYIAQLNPDVINDAYQNLKPEQEEEYNELETQNGK
USA300_FPR3757 FNVAILDNGYYLPEDKYLLVNEQELDYIAQLNPDVINDAYQNLKPEQEEEYNELETQNGK
************************************************************
COL INFLLQTYLKEFRKGGISKKTVYTVTPEISSDVNEFVLDVVVTTPEVKSIYIVRKYKELR
N315 INFLLQTYLKEFRKGGISKKTVYTVTPEISSDVNEFVLDVVVTTPEVKSIYIVRKYKELR
NCTC8325 INFLLQTYLKEFRKGGISKKTVYTVTPEISSDVNEFVLDVVVTTPEVKSIYIVRKYKELR
Newman INFLLQTYLKEFRKGGISKKTVYTVTPEISSDVNEFVLDVVVTTPEVKSIYIVRKYKELR
USA300_FPR3757 INFLLQTYLKEFRKGGISKKTVYTVTPEISSDVNEFVLDVVVTTPEVKSIYIVRKYKELR
************************************************************
COL KYFRKQSFNTRQFIFKAIFNTTKFFHLKKGNTVLFTSDSRPTMSGNFEYIYNEMLRQNLD
N315 KYFRKQSFNTRQFIFKAIFNTTKFFHLKKGNTVLFTSDSRPTMSGNFEYIYNEMLRQNLD
NCTC8325 KYFRKQSFNTRQFIFKAIFNTTKFFHLKKGNTVLFTSDSRPTMSGNFEYIYNEMLRQNLD
Newman KYFRKQSFNTRQFIFKAIFNTTKFFHLKKGNTVLFTSDSRPTMSGNFEYIYNEMLRQNLD
USA300_FPR3757 KYFRKQSFNTRQFIFKAIFNTTKFFHLKKGNTVLFTSDSRPTMSGNFEYIYNEMLRQNLD
************************************************************
COL KKYDIHTVFKANITDRRGIIDKFRLPYLLGKADYIFVDDFHPLIYTVRFRRSQEVIQVWH
N315 KKYDIHTVFKANITDRRGIIDKFRLPYLLGKADYIFVDDFHPLIYTVRFRRSQEVIQVWH
NCTC8325 KKYDIHTVFKANITDRRGIIDKFRLPYLLGKADYIFVDDFHPLIYTVRFRRSQEVIQVWH
Newman KKYDIHTVFKANITDRRGIIDKFRLPYLLGKADYIFVDDFHPLIYTVRFRRSQEVIQVWH
USA300_FPR3757 KKYDIHTVFKANITDRRGIIDKFRLPYLLGKADYIFVDDFHPLIYTVRFRRSQEVIQVWH
************************************************************
COL AVGAFKTVGFSRTGKKGGPFIDSLNHRSYTKAYVSSETDIPFYAEAFGIKEKNVVPTGVP
N315 AVGAFKTVGFSRTGKKGGPFIDSLNHRSYTKAYVSSETDIPFYAEAFGIKEKNVVPTGVP
NCTC8325 AVGAFKTVGFSRTGKKGGPFIDSLNHRSYTKAYVSSETDIPFYAEAFGIKEKNVVPTGVP
Newman AVGAFKTVGFSRTGKKGGPFIDSLNHRSYTKAYVSSETDIPFYAEAFGIKEKNVVPTGVP
USA300_FPR3757 AVGAFKTVGFSRTGKKGGPFIDSLNHRSYTKAYVSSETDIPFYAEAFGIKEKNVVPTGVP
************************************************************
COL RTDVLFDEAYATQIKQEMEDELPIIKGKKVILFAPTFRGSGHGTAHYPFFKIDFERLARY
N315 RTDVLFDEAYATQIKQEMEDELPIIKGKKVILFAPTFRGSGHGTAHYPFFKIDFERLARY
NCTC8325 RTDVLFDEAYATQIKQEMEDELPIIKGKKVILFAPTFRGSGHGTAHYPFFKIDFERLARY
Newman RTDVLFDEAYATQIKQEMEDELPIIKGKKVILFAPTFRGSGHGTAHYPFFKIDFERLARY
USA300_FPR3757 RTDVLFDEAYATQIKQEMEDELPIIKGKKVILFAPTFRGSGHGTAHYPFFKIDFERLARY
************************************************************
COL CEKNNAVVLFKMHPFVKNRLNIADKHKQYFVDVSDFREVNDILFITDLLISDYSSLIYEY
N315 CEKNNAVVLFKMHPFVKNRLNIADKHKQYFVDVSDFREVNDILFITDLLISDYSSLIYEY
NCTC8325 CEKNNAVVLFKMHPFVKNRLNIADKHKQYFVDVSDFREVNDILFITDLLISDYSSLIYEY
Newman CEKNNAVVLFKMHPFVKNRLNIADKHKQYFVDVSDFREVNDILFITDLLISDYSSLIYEY
USA300_FPR3757 CEKNNAVVLFKMHPFVKNRLNIADKHKQYFVDVSDFREVNDILFITDLLISDYSSLIYEY
************************************************************
COL AVFKKPMIFYAFDLEDYITTRDFYEPYESFVPGKIVQSFDALMDALDNEDYEGEKVIPFL
N315 AVFKKPMIFYAFDLEDYITTRDFYEPYESFVPGKIVQSFDALMDALDNEDYEGEKVIPFL
NCTC8325 AVFKKPMIFYAFDLEDYITTRDFYEPYESFVPGKIVQSFDALMDALDNEDYEGEKVIPFL
Newman AVFKKPMIFYAFDLEDYITTRDFYEPYESFVPGKIVQSFDALMDALDNEDYEGEKVIPFL
USA300_FPR3757 AVFKKPMIFYAFDLEDYITTRDFYEPYESFVPGKIVQSFDALMDALDNEDYEGEKVIPFL
************************************************************
COL DKHFKYQDGRSSERLVRNLFGS
N315 DKHFKYQDGRSSERLVRNLFGS
NCTC8325 DKHFKYQDGRSSERLVRNLFGS
Newman DKHFKYQDGRSSERLVRNLFGS
USA300_FPR3757 DKHFKYQDGRSSERLVRNLFGS
**********************
- ↑ Philipp Rathert, Xing Zhang, Christian Freund, Xiaodong Cheng, Albert Jeltsch
Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays.
Chem Biol: 2008, 15(1);5-11
[PubMed:18215768] [WorldCat.org] [DOI] (P p)Jonathan G Swoboda, Jennifer Campbell, Timothy C Meredith, Suzanne Walker
Wall teichoic acid function, biosynthesis, and inhibition.
Chembiochem: 2010, 11(1);35-45
[PubMed:19899094] [WorldCat.org] [DOI] (I p)Franco K K Li, Liam J Worrall, Robert T Gale, Eric D Brown, Natalie C J Strynadka
Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance.
Sci Adv: 2024, 10(9);eadj3864
[PubMed:38416829] [WorldCat.org] [DOI] (I p)