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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001018000
- symbol?: ausA
- synonym:
- description?: non-ribosomal peptide synthetase
- non-ribosomal peptide synthetase
- gramicidin S synthetase 2 related protein
- non-ribosomal peptide synthetase, putative
- aureusimine non-ribosomal peptide synthetase
- non-ribosomal peptide-like protein and polyketide synthesis
- protein related to non-ribosomal peptide and polyketidesynthesis
- putative non-ribosomal peptide synthetase
- surfactin/siderophore synthetase
- surfactin/siderphore synthesase
- surfactin synthetase
- Surfactin synthetase subunit 2
- thioester reductase domain-containing protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1284181..1291617
- synteny block?: BlockID0005460
- occurrence?: in 100% of 34 strains
ausA : aureusimine (phevalin) non-ribosomal peptide synthetase AusA [1]
• A partial crystal structure is available : 4F6L
Staphylococci assemble dipeptide-derived "aureusimine" pyrazinones using a modified nonribosomal peptide synthetase system. AusB transfers CoA-derived 4'-phosphopantetheine posttranslational modifications onto apo-peptidyl carrier protein domains of AusA to generate a functional aureusimine (pyrazinone) synthetase. Phenylvaline, tyrosylvaline or leucylvaline dipeptides are cyclized to the monoketopiperazine / pyrazinone aureusimines phevalin, tyrvalin and leuvalin. Although the role of aureusimines is not fully clear, phevalin is a calpain inhibitor and aureusimines plays a role in intracellular survival and escape from epithelial and macrophage cells.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0180
08BA02176:
C248_0168
11819-97:
MS7_0172
6850:
RSAU_000130
71193:
ST398NM01_0193
ECT-R 2:
ECTR2_142
ED133:
SAOV_0123
ED98:
SAAV_0147
HO 5096 0412:
SAEMRSA15_01440
JH1:
SaurJH1_0169
JH9:
SaurJH9_0164
JKD6008:
SAA6008_00157 (ausA)
JKD6159:
SAA6159_00160 (ausA)
LGA251:
SARLGA251_01500
M013:
M013TW_0166
MRSA252:
SAR0180
MSHR1132:
SAMSHR1132_01520
MSSA476:
SAS0154
Mu3:
SAHV_0178
Mu50:
SAV0179
MW2:
MW0153
RF122:
SAB0119
ST398:
SAPIG0193
T0131:
SAT0131_00170
TCH60:
HMPREF0772_10320
TW20:
SATW20_01890
USA300_TCH1516:
USA300HOU_0192
VC40:
SAVC_00660
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 | |
| JSNZ |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MIMGNLRFQQEYFRIYKNNTESTTHRNAYWVKLAKNVEATKMMYALSTIVQQHASIRHFF
N315 MIMGNLRFQQEYFRIYKNNTESTTHRNAYWVKLAKNVEATKMMYALSTIVQQHASIRHFF
NCTC8325 MIMGNLRFQQEYFRIYKNNTESTTHRNAYWVKLAKNVEATKMMYALSTIVQQHASIRHFF
Newman --MGNLRFQQEYFRIYKNNTESTTHRNAYWVKLAKNVEATKMMYALSTIVQQHASIRHFF
USA300_FPR3757 MIMGNLRFQQEYFRIYKNNTESTTHRNAYWVKLAKNVEATKMMYALSTIVQQHASIRHFF
**********************************************************
COL DVTTDDNLTMILHEFLPFIEIKQVPSSSANYDLEAFFKQELSTYHFNDSPLFKVKLFQFA
N315 DVTTDDNLTMILHEFLPFIEIKQVPSSSANYDLEAFFKQELSTYHFNDSPLFKVKLFQFA
NCTC8325 DVTTDDNLTMILHEFLPFIEIKQVPSSSANYDLEAFFKQELSTYHFNDSPLFKVKLFQFA
Newman DVTTDDNLTMILHEFLPFIEIKQVPSSSANYDLEAFFKQELSTYHFNDSPLFKVKLFQFA
USA300_FPR3757 DVTTDDNLTMILHEFLPFIEIKQVPSSSANYDLEAFFKQELSTYHFNDSPLFKVKLFQFA
************************************************************
COL DAAYILLDFHVSIFDDSQIDIFLDDLCNAYRGNTVINNTRQHAHINRNDDKDNQDASHIA
N315 DAAYILLDFHVSIFDDSQIDIFLDDLCNAYRGNTVINNTRQHAHINRNDDKDNQDASHIA
NCTC8325 DAAYILLDFHVSIFDDSQIDIFLDDLCNAYRGNTVINNTRQHAHINRNDDKDNQDASHIA
Newman DAAYILLDFHVSIFDDSQIDIFLDDLCNAYRGNTVINNTRQHAHINRNDDKDNQDASHIA
USA300_FPR3757 DAAYILLDFHVSIFDDSQIDIFLDDLCNAYRGNTVINNTRQHAHINRNDDKDNQDASHIA
************************************************************
COL LDSNYFRLENNSDIHIDSYFPIKHPFEQALYQTYLIDDMTSIDMASLAVSVYLANHIMSQ
N315 LDSNYFRLENNSDIHIDSYFPIKHPFEQALYQTYLIDDMTSIDMASLAVSVYLANHIMSQ
NCTC8325 LDSNYFRLENNSDIHIDSYFPIKHPFEQALYQTYLIDDMTSIDMASLAVSVYLANHIMSQ
Newman LDSNYFRLENNSDIHIDSYFPIKHPFEQALYQTYLIDDMTSIDMASLAVSVYLANHIMSQ
USA300_FPR3757 LDSNYFRLENNSDIHIDSYFPIKHPFEQALYQTYLIDDMTSIDMASLAVSVYLANHIMSQ
************************************************************
COL QHDVTLGIHVPSHLPNDLHGNIVPLTLTIDAKDVCQRFTTDFNKCVLQNMSQLQCAKSSL
N315 QHDVTLGIHVPSHLPNDLHGNIVPLTLTIDAKDVCQRFTTDFNKCVLQNMSQLQCAKSSL
NCTC8325 QHDVTLGIHVPSHLPNDLHGNIVPLTLTIDAKDVCQRFTTDFNKCVLQNMSQLQCAKSSL
Newman QHDVTLGIHVPSHLPNDLHGNIVPLTLTIDAKDVCQRFTTDFNKCVLQNMSQLQCAKSSL
USA300_FPR3757 QHDVTLGIHVPSHLPNDLHGNIVPLTLTIDAKDVCQRFTTDFNKCVLQNMSQLQCAKSSL
************************************************************
COL SLETIFHCYHHMMSCCNDVIEDVHQIHDAHTSLADIEIFPHQHGFKIIYNSAAYDLLSIE
N315 SLETIFHCYHHMMSCCNDVIEDVHQIHDAHTSLADIEIFPHQHGFKIIYNSAAYDLLSIE
NCTC8325 SLETIFHCYHHMMSCCNDVIEDVHQIHDAHTSLADIEIFPHQHGFKIIYNSAAYDLLSIE
Newman SLETIFHCYHHMMSCCNDVIEDVHQIHDAHTSLADIEIFPHQHGFKIIYNSAAYDLLSIE
USA300_FPR3757 SLETIFHCYHHMMSCCNDVIEDVHQIHDAHTSLADIEIFPHQHGFKIIYNSAAYDLLSIE
************************************************************
COL TLSDLVRNIYLQITEENGNKRTTVDELNLMTERDIQLYDDINLSLPEIDDAQTVVTLFEQ
N315 TLSDLVRNIYLQITEENGNKRTTVDELNLMTERDIQLYDDINLSLPEIDDAQTVVTLFEQ
NCTC8325 TLSDLVRNIYLQITEENGNKRTTVDELNLMTERDIQLYDDINLSLPEIDDAQTVVTLFEQ
Newman TLSDLVRNIYLQITEENGNKRTTVDELNLMTERDIQLYDDINLSLPEIDDAQTVVTLFEQ
USA300_FPR3757 TLSDLVRNIYLQITEENGNKRTTVDELNLMTERDIQLYDDINLSLPEIDDAQTVVTLFEQ
************************************************************
COL QVEATPNHVAVQFDGVFITYQTLNARANDLAHRLRNQYGVEPNDRVAVIAEKSIEMIIAM
N315 QVEATPNHVAVQFDGVFITYQTLNARANDLAHRLRNQYGVEPNDRVAVIAEKSIEMIIAM
NCTC8325 QVEATPNHVAVQFDGVFITYQTLNARANDLAHRLRNQYGVEPNDRVAVIAEKSIEMIIAM
Newman QVEATPNHVAVQFDGVFITYQTLNARANDLAHRLRNQYGVEPNDRVAVIAEKSIEMIIAM
USA300_FPR3757 QVEATPNHVAVQFDGVFITYQTLNARANDLAHRLRNQYGVEPNDRVAVIAEKSIEMIIAM
************************************************************
COL IGVLKAGGAYVPIDPNYPSDRQEYILKDVTPKVVITYQALYENGKQNINHIDLNKIAWKN
N315 IGVLKAGGAYVPIDPNYPSDRQEYILKDATPKVVITYQALYENGKQNINHIDLNKIAWKN
NCTC8325 IGVLKAGGAYVPIDPNYPSDRQEYILKDVTPKVVITYQALYENGKQNINHIDLNKIAWKN
Newman IGVLKAGGAYVPIDPNYPSDRQEYILKDVTPKVVITYQALYENGKQNINHIDLNKIAWKN
USA300_FPR3757 IGVLKAGGAYVPIDPNYPSDRQEYILKDVTPKVVITYQALYENGKQNINHIDLNKIAWKN
****************************.*******************************
COL IDNLSKCNTLEDHAYVIYTSGTTGNPKGTLIPHRGIVRLVHQNHYVPLNEETTILLSGTI
N315 IDNLSKCNTLEDHAYVIYTSGTTGNPKGTLIPHRGIVRLVHRNHYVPLNEETTILLSGTI
NCTC8325 IDNLSKCNTLEDHAYVIYTSGTTGNPKGTLIPHRGIVRLVHQNHYVPLNEETTILLSGTI
Newman IDNLSKCNTLEDHAYVIYTSGTTGNPKGTLIPHRGIVRLVHQNHYVPLNEETTILLSGTI
USA300_FPR3757 IDNLSKCNTLEDHAYVIYTSGTTGNPKGTLIPHRGIVRLVHQNHYVPLNEETTILLSGTI
*****************************************:******************
COL AFDAATFEIYGALLNGGKLIVAKKEQLLNPIAVEQLINENDVNTMWLTSSLFNQIASERI
N315 AFDAATFEIYGALLNGGKLIVAKKEQLLNPIAVEQLINENDVNTMWLTSSLFNQIASERI
NCTC8325 AFDAATFEIYGALLNGGKLIVAKKEQLLNPIAVEQLINENDVNTMWLTSSLFNQIASERI
Newman AFDAATFEIYGALLNGGKLIVAKKEQLLNPIAVEQLINENDVNTMWLTSSLFNQIASERI
USA300_FPR3757 AFDAATFEIYGALLNGGKLIVAKKEQLLNPIAVEQLINENDVNTMWLTSSLFNQIASERI
************************************************************
COL EVLVSLKYLLIGGEVLNAKWVDLLNQKPKHPQIINGYGPTENTTFTTTYNIPNKVPNRIP
N315 EVLVPLKYLLIGGEVLNAKWVDLLNQKPKHPQIINGYGPTENTTFTTTYNIPNKVPNRIP
NCTC8325 EVLVPLKYLLIGGEVLNAKWVDLLNQKPKHPQIINGYGPTENTTFTTTYNIPNKVPNRIP
Newman EVLVPLKYLLIGGEVLNAKWVDLLNQKPKHPQIINGYGPTENTTFTTTYNIPNKVPNRIP
USA300_FPR3757 EVLVPLKYLLIGGEVLNAKWVDLLNQKPKHPQIINGYGPTENTTFTTTYNIPNKVPNRIP
****.*******************************************************
COL IGKPILGTHVYIMQGERRCGVGIPGELCTSGFGLAAGYLNQPELTADKFIKDSNINQLMY
N315 IGKPILGTHVYIMQGERRCGVGIPGELCTSGFGLAAGYLNQPELTADKFIKDSNINQLMY
NCTC8325 IGKPILGTHVYIMQGERRCGVGIPGELCTSGFGLAAGYLNQPELTADKFIKDSNINQLMY
Newman IGKPILGTHVYIMQGERRCGVGIPGELCTSGFGLAAGYLNQPELTADKFIKDSNINQLMY
USA300_FPR3757 IGKPILGTHVYIMQGERRCGVGIPGELCTSGFGLAAGYLNQPELTADKFIKDSNINQLMY
************************************************************
COL RSGDIVRLLPDGNIDYLYRKDKQVKIRGFRIELSEVEHALERIQGINKAVVIVQNHDQDQ
N315 RSGDIVRLLPDGNIDYLYRKDKQVKIRGFRIELSEVEHALERIQGINKAVVIVQNHDQDQ
NCTC8325 RSGDIVRLLPDGNIDYLYRKDKQVKIRGFRIELSEVEHALERIQGINKAVVIVQNHDQDQ
Newman RSGDIVRLLPDGNIDYLYRKDKQVKIRGFRIELSEVEHALERIQGINKAVVIVQNHDQDQ
USA300_FPR3757 RSGDIVRLLPDGNIDYLYRKDKQVKIRGFRIELSEVEHALERIQGINKAVVIVQNHDQDQ
************************************************************
COL YIVAYYEAMHTLSHNKIKSQLRMTLPEYMIPVNFMHIEQIPITINGKLDKKALPIMDYVD
N315 YIVAYYEAMHTLSHNKIKSQLRMTLPEYMIPVNFMHIEQIPITINGKLDKKALPIMDYVD
NCTC8325 YIVAYYEAMHTLSHNKIKSQLRMTLPEYMIPVNFMHIEQIPITINGKLDKKALPIMDYVD
Newman YIVAYYEAMHTLSHNKIKSQLRMTLPEYMIPVNFMHIEQIPITINGKLDKKALPIMDYVD
USA300_FPR3757 YIVAYYEAMHTLSHNKIKSQLRMTLPEYMIPVNFMHIEQIPITINGKLDKKALPIMDYVD
************************************************************
COL TDAYVAPSTDTEHLLCQIFADILHVNQVGIHDNFFELGGHSLKATLVVNRIEASTGKRLQ
N315 TDAYVAPSTDTEHLLCQIFADILHVNQVGIHDNFFELGGHSLKATLVVNRIEASTGKRLQ
NCTC8325 TDAYVAPSTDTEHLLCQIFADILHVNQVGIHDNFFELGGHSLKATLVVNRIEASTGKRLQ
Newman TDAYVAPSTDTEHLLCQIFADILHVNQVGIHDNFFELGGHSLKATLVVNRIEASTGKRLQ
USA300_FPR3757 TDAYVAPSTDTEHLLCQIFADILHVNQVGIHDNFFELGGHSLKATLVVNRIEASTGKRLQ
************************************************************
COL IGDLLQKPTVFELAQAIAKVQEQNYEVIPETIVKDDYVLSSAQKRMYLLWKSNHKDTVYN
N315 IGDLLQKPTVFELAQAIAKVQEQNYEVIPEAIVKDDYVLSSAQKRMYLLWKSNHKDTVYN
NCTC8325 IGDLLQKPTVFELAQAIAKVQEQNYEVIPETIVKDDYVLSSAQKRMYLLWKSNHKDTVYN
Newman IGDLLQKPTVFELAQAIAKVQEQNYEVIPETIVKDDYVLSSAQKRMYLLWKSNHKDTVYN
USA300_FPR3757 IGDLLQKPTVFELAQAIAKVQEQNYEVIPETIVKDDYVLSSAQKRMYLLWKSNHKDTVYN
******************************:*****************************
COL VPFLWRLSSELNVAQLRQAVQRLIARHEILRTQYIVVDDEVRQRIVADVAVDFEEVNTHF
N315 VPFLWRLSSGLNVAQLQQAVQHLIARHEILRTQYIVVDDEVRQRIVADVVADFEEVNTHF
NCTC8325 VPFLWRLSSELNVAQLRQAVQRLIARHEILRTQYIVVDDEVRQRIVADVAVDFEEVNTHF
Newman VPFLWRLSSELNVAQLRQAVQRLIARHEILRTQYIVVDDEVRQRIVADVAVDFEEVNTHF
USA300_FPR3757 VPFLWRLSSELNVAQLRQAVQRLIARHEILRTQYIVVDDEVRQRIVADVAVDFEEVNTHF
********* ******:****:***************************..*********
COL TDEQEIMRQFVAPFNLEKPSQIRVRYIRSPLHAYLFIDTHHIINDGMSNIQLMNDLNALY
N315 TDEQEIMRQFVAPFNLEKPSQIRVRYIRSPLHAYLFIDTHHIINDGMSNIQLMNDLNALY
NCTC8325 TDEQEIMRQFVAPFNLEKPSQIRVRYIRSPLHAYLFIDTHHIINDGMSNIQLMNDLNALY
Newman TDEQEIMRQFVAPFNLEKPSQIRVRYIRSPLHAYLFIDTHHIINDGMSNIQLMNDLNALY
USA300_FPR3757 TDEQEIMRQFVAPFNLEKPSQIRVRYIRSPLHAYLFIDTHHIINDGMSNIQLMNDLNALY
************************************************************
COL QHKLLLPLKLQYKDYSEWMSHRDMTKHRQYWLSQFKDEVPILSLPTDYVRPNIKTTNGAM
N315 QHKLLLPLKLQYKDYSEWMSHRDMTKHRQYWLSQFKDEVPILSLPTDYVRPNIKTTNGAM
NCTC8325 QHKLLLPLKLQYKDYSEWMSHRDMTKHRQYWLSQFKDEVPILSLPTDYVRPNIKTTNGAM
Newman QHKLLLPLKLQYKDYSEWMSHRDMTKHRQYWLSQFKDEVPILSLPTDYVRPNIKTTNGAM
USA300_FPR3757 QHKLLLPLKLQYKDYSEWMSHRDMTKHRQYWLSQFKDEVPILSLPTDYVRPNIKTTNGAM
************************************************************
COL MSFTMNQQMRQLLQKYVEKHQITDFMFFMSVVMTLLSRYARKDDVVVGSVMSARMHKGTE
N315 MSFTMNQQMRQLLQKYVEKHQITDFMFFMSVVMTLLSRYARKDDVVVGSVMSARMHKGTE
NCTC8325 MSFTMNQQMRQLLQKYVEKHQITDFMFFMSVVMTLLSRYARKDDVVVGSVMSARMHKGTE
Newman MSFTMNQQMRQLLQKYVEKHQITDFMFFMSVVMTLLSRYARKDDVVVGSVMSARMHKGTE
USA300_FPR3757 MSFTMNQQMRQLLQKYVEKHQITDFMFFMSVVMTLLSRYARKDDVVVGSVMSARMHKGTE
************************************************************
COL QMLGMFANTLVYRGQPSPDKMWTQFLQEVKEMSLEAYEHQEYPFECLVNDLDQSHDASRN
N315 QMLGMFANTLVYRGQPSPDKMWTQFLQEVKEMSLEAYEHQEYPFECLVNDLDQSHDASRN
NCTC8325 QMLGMFANTLVYRGQPSPDKMWTQFLQEVKEMSLEAYEHQEYPFECLVNDLDQSHDASRN
Newman QMLGMFANTLVYRGQPSPDKMWTQFLQEVKEMSLEAYEHQEYPFECLVNDLDQSHDASRN
USA300_FPR3757 QMLGMFANTLVYRGQPSPDKMWTQFLQEVKEMSLEAYEHQEYPFECLVNDLDQSHDASRN
************************************************************
COL PLFDVMLVLQNNETNHAHFGHSKLTHIQPKSVTAKFDLSFIIEEDRDDYTINIEYNTDLY
N315 PLFDVMLVLQNNETNHAHFGHSKLTHIQPKSVTAKFDLSFIIEEDRDDYTINIEYNTDLY
NCTC8325 PLFDVMLVLQNNETNHAHFGHSKLTHIQPKSVTAKFDLSFIIEEDRDDYTINIEYNTDLY
Newman PLFDVMLVLQNNETNHAHFGHSKLTHIQPKSVTAKFDLSFIIEEDRDDYTINIEYNTDLY
USA300_FPR3757 PLFDVMLVLQNNETNHAHFGHSKLTHIQPKSVTAKFDLSFIIEEDRDDYTINIEYNTDLY
************************************************************
COL HSETVRHMGNQCMIMIDYILKHQDTLQICDIPNGTEELLNWVNTHVNDRMLNVPGNKSII
N315 HSETVRHMGNQCMIMIDYILKHQDTLQICDIPNGTEELLNWVNTHVNDRMLNVPGNKSII
NCTC8325 HSETVRHMGNQCMIMIDYILKHQDTLQICDIPNGTEELLNWVNTHVNDRMLNVPGNKSII
Newman HSETVRHMGNQCMIMIDYILKHQDTLQICDIPNGTEELLNWVNTHVNDRMLNVPGNKSII
USA300_FPR3757 HSETVRHMGNQCMIMIDYILKHQDTLQICDIPNGTEELLNWVNTHVNDRMLNVPGNKSII
************************************************************
COL SYFNEVVSRQGNHVALVMNDLTMTYETLRNYVDAIAHMLLSNGVGNGQRVALFTERSFEM
N315 SYFNEVVSRQGNHVALVMNDLTMTYETLRNYVDAIAHMLLSNGVGNGQRVALFTERSFEM
NCTC8325 SYFNEVVSRQGNHVALVMNDLTMTYETLRNYVDAIAHMLLSNGVGNGQRVALFTERSFEM
Newman SYFNEVVSRQGNHVALVMNDLTMTYETLRNYVDAIAHMLLSNGVGNGQRVALFTERSFEM
USA300_FPR3757 SYFNEVVSRQGNHVALVMNDLTMTYETLRNYVDAIAHMLLSNGVGNGQRVALFTERSFEM
************************************************************
COL IAAMLATVKVGASYIPIDIDFPNKRQGAILEDAKVTAVMSYGVEIETTLPVIQLENAKGF
N315 IAAMLATVKVGASYIPIDIDFPNKRQGAILEDAKVTAVMSYGVEIETTLPVIQLENAKGF
NCTC8325 IAAMLATVKVGASYIPIDIDFPNKRQGAILEDAKVTAVMSYGVEIETTLPVIQLENAKGF
Newman IAAMLATVKVGASYIPIDIDFPNKRQGAILEDAKVTAVMSYGVEIETTLPVIQLENAKGF
USA300_FPR3757 IAAMLATVKVGASYIPIDIDFPNKRQGAILEDAKVTAVMSYGVEIETTLPVIQLENAKGF
************************************************************
COL VESKENEQYDDLHGNQLENTAMLDNEMYAIYTSGTTGMPKGVAIRQRNLLNLVHAWSTEL
N315 VESKENEQYDDLHGNQLENTAMLDNEMYAIYTSGTTGMPKGVAIRQRNLLNLVHAWSTEL
NCTC8325 VESKENEQYDDLHGNQLENTAMLDNEMYAIYTSGTTGMPKGVAIRQRNLLNLVHAWSTEL
Newman VESKENEQYDDLHGNQLENTAMLDNEMYAIYTSGTTGMPKGVAIRQRNLLNLVHAWSTEL
USA300_FPR3757 VESKENEQYDDLHGNQLENTAMLDNEMYAIYTSGTTGMPKGVAIRQRNLLNLVHAWSTEL
************************************************************
COL QLGDNEVFLQHANIVFDASVMEIYCCLLNGHTLVIPDREERVNPEQLQQLINKHRVTVAS
N315 QLGDNEVFLQHANIVFDASVMEIYCCLLNGHTLVIPDREERVNPEQLQQLINKHRVTVAS
NCTC8325 QLGDNEVFLQHANIVFDASVMEIYCCLLNGHTLVIPDREERVNPEQLQQLINKHRVTVAS
Newman QLGDNEVFLQHANIVFDASVMEIYCCLLNGHTLVIPDREERVNPEQLQQLINKHRVTVAS
USA300_FPR3757 QLGDNEVFLQHANIVFDASVMEIYCCLLNGHTLVIPDREERVNPEQLQQLINKHRVTVAS
************************************************************
COL IPLQMCSVMEDFYIEKLITGGATSTASFVKYIEKHCGTYFNAYGPSESTVITSYWSHHCG
N315 IPLQMCSIMEDFYIEKLITGGATSTASFVKYIEKHCGTYFNAYGPSESTVITSYWSHHCG
NCTC8325 IPLQMCSVMEDFYIEKLITGGATSTASFVKYIEKHCGTYFNAYGPSESTVITSYWSHHCG
Newman IPLQMCSVMEDFYIEKLITGGATSTASFVKYIEKHCGTYFNAYGPSESTVITSYWSHHCG
USA300_FPR3757 IPLQMCSVMEDFYIEKLITGGATSTASFVKYIEKHCGTYFNAYGPSESTVITSYWSHHCG
*******:****************************************************
COL DLIPETIPIGKPLSNIQVYIMSDGLLCGIGMPGELCIAGDSLAIGYINRPELMADKWQNN
N315 DLIPETIPIGKPLSNIQVYIMSDGLLCGIGMPGELCIAGDSLAIGYINRPELMADKWQNN
NCTC8325 DLIPETIPIGKPLSNIQVYIMSDGLLCGIGMPGELCIAGDSLAIGYINRPELMADKWQNN
Newman DLIPETIPIGKPLSNIQVYIMSDGLLCGIGMPGELCIAGDSLAIGYINRPELMADKWQNN
USA300_FPR3757 DLIPETIPIGKPLSNIQVYIMSDGLLCGIGMPGELCIAGDSLAIGYINRPELMADKWQNN
************************************************************
COL PFGKGKLYHSGDLARYTSDGQIEFLGRIDKQVKVNGYRIELDEIENAILAIRGISDCVVT
N315 PFGKGKLYHSGDLARYTSDGQIEFLGRIDKQVKVNGYRIELDEIENVILAIRGISDCVVT
NCTC8325 PFGKGKLYHSGDLARYTSDGQIEFLGRIDKQVKVNGYRIELDEIENAILAIRGISDCVVT
Newman PFGKGKLYHSGDLARYTSDGQIEFLGRIDKQVKVNGYRIELDEIENAILAIRGISDCVVT
USA300_FPR3757 PFGKGKLYHSGDLARYTSDGQIEFLGRIDKQVKVNGYRIELDEIENAILAIRGISDCVVT
**********************************************.*************
COL VSHFDTHDILNAYYVGEQQVEQDLKQYLNDQLPKYMIPKTITHIDCMPLTTNDKVDTTRL
N315 VSHFDTHDILNAYYVGEQQVEQDLKQYLNDQLPKYMIPKTITHIDCMPLTTNDKVDTTRL
NCTC8325 VSHFDTHDILNAYYVGEQQVEQDLKQYLNDQLPKYMIPKTITHIDCMPLTTNDKVDTTRL
Newman VSHFDTHDILNAYYVGEQQVEQDLKQYLNDQLPKYMIPKTITHIDCMPLTTNDKVDTTRL
USA300_FPR3757 VSHFDTHDILNAYYVGEQQVEQDLKQYLNDQLPKYMIPKTITHIDCMPLTTNDKVDTTRL
************************************************************
COL PNPSPIQQSNKVYSEPSNEIEQTFVDVFGEVLKQNDVGVDDDFFELGGNSLEAMLVVSHL
N315 PNPSPIQQSNKVYSEPSNEIEQTFVDVFGEVLKQNDVGVDDDFFELGGNSLEAMLVVSHL
NCTC8325 PNPSPIQQSNKVYSEPSNEIEQTFVDVFGEVLKQNDVGVDDDFFELGGNSLEAMLVVSHL
Newman PNPSPIQQSNKVYSEPSNEIEQTFVDVFGEVLKQNDVGVDDDFFELGGNSLEAMLVVSHL
USA300_FPR3757 PNPSPIQQSNKVYSEPSNEIEQTFVDVFGEVLKQNDVGVDDDFFELGGNSLEAMLVVSHL
************************************************************
COL KRFGHHISMQTLYQYKTVRQIVNYMYQNQQSLVALPDNLSELQKIVMSRYNLGILEDSLS
N315 KRFGHHISMQTLYQYKTVRQIVNYMYQNQQSLVALPDNLSELQKIVMSRYNLGILEDSLS
NCTC8325 KRFGHHISMQTLYQYKTVRQIVNYMYQNQQSLVALPDNLSELQKIVMSRYNLGILEDSLS
Newman KRFGHHISMQTLYQYKTVRQIVNYMYQNQQSLVALPDNLSELQKIVMSRYNLGILEDSLS
USA300_FPR3757 KRFGHHISMQTLYQYKTVRQIVNYMYQNQQSLVALPDNLSELQKIVMSRYNLGILEDSLS
************************************************************
COL HRPLGNTLLTGATGFLGAYLIEVLQGYSHRIYCFIRADNEEIAWYKLMTNLNDYFSEETV
N315 HRPLGNTLLTGATGFLGAYLIEALQGYSHRIYCFIRADNEEIAWYKLMTNLNDYFSEETV
NCTC8325 HRPLGNTLLTGATGFLGAYLIEVLQGYSHRIYCFIRADNEEIAWYKLMTNLNDYFSEETV
Newman HRPLGNTLLTGATGFLGAYLIEVLQGYSHRIYCFIRADNEEIAWYKLMTNLNDYFSEETV
USA300_FPR3757 HRPLGNTLLTGATGFLGAYLIEVLQGYSHRIYCFIRADNEEIAWYKLMTNLNDYFSEETV
**********************.*************************************
COL EIMLSNIEVIVGDFECMDDVVLPENMDTIIHAGARTDHFGDDDEFEKVNVQGTVDVIRLA
N315 EMMLSNIEVIVGDFECMDDVVLPENMDTIIHAGARTDHFGDDDEFEKVNVQGTVDVIRLA
NCTC8325 EIMLSNIEVIVGDFECMDDVVLPENMDTIIHAGARTDHFGDDDEFEKVNVQGTVDVIRLA
Newman EIMLSNIEVIVGDFECMDDVVLPENMDTIIHAGARTDHFGDDDEFEKVNVQGTVDVIRLA
USA300_FPR3757 EIMLSNIEVIVGDFECMDDVVLPENMDTIIHAGARTDHFGDDDEFEKVNVQGTVDVIRLA
*:**********************************************************
COL QQHHARLIYVSTISVGTYFDIDTEDVTFSEADVYKGQLLTSPYTRSKFYSELKVLEAVNN
N315 QQHHARLIYVSTISVGTYFDIDTEDVTFSEADVYKGQLLTSPYTRSKFYSELKVLEAVNN
NCTC8325 QQHHARLIYVSTISVGTYFDIDTEDVTFSEADVYKGQLLTSPYTRSKFYSELKVLEAVNN
Newman QQHHARLIYVSTISVGTYFDIDTEDVTFSEADVYKGQLLTSPYTRSKFYSELKVLEAVNN
USA300_FPR3757 QQHHARLIYVSTISVGTYFDIDTEDVTFSEADVYKGQLLTSPYTRSKFYSELKVLEAVNN
************************************************************
COL GLDGRIVRVGNLTNPYNGRWHMRNIKTNRFSMVMNDLLQLDCIGVSMAEMPVDFSFVDTT
N315 GLDGRIVRVGNLTSPYNGRWHMRNIKTNRFSMVMNDLLQLDCIGVSMAEMPVDFSFVDTT
NCTC8325 GLDGRIVRVGNLTNPYNGRWHMRNIKTNRFSMVMNDLLQLDCIGVSMAEMPVDFSFVDTT
Newman GLDGRIVRVGNLTNPYNGRWHMRNIKTNRFSMVMNDLLQLDCIGVSMAEMPVDFSFVDTT
USA300_FPR3757 GLDGRIVRVGNLTNPYNGRWHMRNIKTNRFSMVMNDLLQLDCIGVSMAEMPVDFSFVDTT
*************.**********************************************
COL ARQIVALAQVNTPQIIYHVLSPNKMPVKSLLECVKRKEIELVSDESFNEILQKQDMYETI
N315 ARQIVALAQVNTPQIIYHVLSPNKMPVKSLLECVKRKEIELVSDESFNEILQKQDMYETI
NCTC8325 ARQIVALAQVNTPQIIYHVLSPNKMPVKSLLECVKRKEIELVSDESFNEILQKQDMYETI
Newman ARQIVALAQVNTPQIIYHVLSPNKMPVKSLLECVKRKEIELVSDESFNEILQKQDMYETI
USA300_FPR3757 ARQIVALAQVNTPQIIYHVLSPNKMPVKSLLECVKRKEIELVSDESFNEILQKQDMYETI
************************************************************
COL GLTSVDREQQLAMIDTTLTLKIMNHISEKWPTITNNWLYHWAQYIKTIFNK
N315 GLTSVDREQQLAMIDTTLTLKIMNHISEKWPTITNNWLYHWAQYIKTIFNK
NCTC8325 GLTSVDREQQLAMIDTTLTLKIMNHISEKWPTITNNWLYHWAQYIKTIFNK
Newman GLTSVDREQQLAMIDTTLTLKIMNHISEKWPTITNNWLYHWAQYIKTIFNK
USA300_FPR3757 GLTSVDREQQLAMIDTTLTLKIMNHISEKWPTITNNWLYHWAQYIKTIFNK
***************************************************
- ↑ M E Alvarez, C B White, J Gregory, G C Kydd, A Harris, H H Sun, A M Gillum, R Cooper
Phevalin, a new calpain inhibitor, from a Streptomyces sp.
J Antibiot (Tokyo): 1995, 48(10);1165-7
[PubMed:7490226] [WorldCat.org] [DOI] (P p)Morgan A Wyatt, Wenliang Wang, Christelle M Roux, Federico C Beasley, David E Heinrichs, Paul M Dunman, Nathan A Magarvey
Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence.
Science: 2010, 329(5989);294-6
[PubMed:20522739] [WorldCat.org] [DOI] (I p)Michael Zimmermann, Michael A Fischbach
A family of pyrazinone natural products from a conserved nonribosomal peptide synthetase in Staphylococcus aureus.
Chem Biol: 2010, 17(9);925-30
[PubMed:20851341] [WorldCat.org] [DOI] (I p)Fei Sun, Hoonsik Cho, Do-Won Jeong, Chunling Li, Chuan He, Taeok Bae
Aureusimines in Staphylococcus aureus are not involved in virulence.
PLoS One: 2010, 5(12);e15703
[PubMed:21209955] [WorldCat.org] [DOI] (I e)Daniel J Wilson, Ce Shi, Aaron M Teitelbaum, Andrew M Gulick, Courtney C Aldrich
Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.
Biochemistry: 2013, 52(5);926-37
[PubMed:23302043] [WorldCat.org] [DOI] (I p)Sebastian Blättner, Sudip Das, Kerstin Paprotka, Ursula Eilers, Markus Krischke, Dorothee Kretschmer, Christian W Remmele, Marcus Dittrich, Tobias Müller, Christina Schuelein-Voelk, Tobias Hertlein, Martin J Mueller, Bruno Huettel, Richard Reinhardt, Knut Ohlsen, Thomas Rudel, Martin J Fraunholz
Staphylococcus aureus Exploits a Non-ribosomal Cyclic Dipeptide to Modulate Survival within Epithelial Cells and Phagocytes.
PLoS Pathog: 2016, 12(9);e1005857
[PubMed:27632173] [WorldCat.org] [DOI] (I e)