⊟Summary[edit | edit source]

pan ID^?: SAUPAN000858000
symbol^?: plc
synonym:
description^?: 1-phosphatidylinositol phosphodiesterase
- 1-phosphatidylinositol phosphodiesterase
- phosphatidylinositol-specific phospholipase C
- 1-phosphatidylinositol phosphodiesterase precurosr
- 1-phosphatidylinositol phosphodiesterase (Phosphatidylinositol diacylglycerol-lyase) (Phosphatidylinositol-specific phospholipase C) (PI-PLC)
- phosphatidylinositol diacylglycerol-lyase
- pseudogene
strand^?: +
coordinates^?: 1126966..1127952
synteny block^?: BlockID0004190
occurrence^?: in 100% of 34 strains

plc : 1-phosphatidylinositol-specific phospholipase C ^[1]

• A crystal structure is available : 3V18

⊟Orthologs[edit | edit source]

COL:

SACOL0078 (plc)

N315:

SA0091 (plc)

NCTC8325:

SAOUHSC_00051

Newman:

NWMN_0041

USA300_FPR3757:

SAUSA300_0099 (plc)

04-02981:

SA2981_0095 (plc)

08BA02176:

C248_0089 (plc)

11819-97:

MS7_0088

6850:

RSAU_000049 (plc)

71193:

ST398NM01_0113

ECT-R 2:

ECTR2_52

ED133:

SAOV_0049 (plc)

ED98:

SAAV_0043 (plc)

HO 5096 0412:

SAEMRSA15_00670 (plc)

JH1:

SaurJH1_0086

JH9:

SaurJH9_0083

JKD6008:

SAA6008_00080 (plc)

JKD6159:

SAA6159_00079 (plc)

JSNZ:

JSNZ_000042

LGA251:

SARLGA251_00750 (plc)

M013:

M013TW_0088

MRSA252:

SAR0105 (plc)

MSHR1132:

SAMSHR1132_00710

MSSA476:

SAS0070 (plc)

Mu3:

SAHV_0094 (plc)

Mu50:

SAV0095 (plc)

MW2:

MW0070 (plc)

RF122:

SAB0038 (plc)

ST398:

SAPIG0113

T0131:

SAT0131_00082

TCH60:

HMPREF0772_10395 (plc)

TW20:

SATW20_01140 (plc)

USA300_TCH1516:

USA300HOU_0108 (plc)

VC40:

SAVC_00225

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MKKCIKTLFLSIILVVMSGWYHSAHASDSLSKSPENWMSKLDDGKHLTEINIPGSHDSGS
N315            MKKCIKTLFLSIILVVMGGWYHSAHASDSLSKSPENWMSKLDESKHLTEINMPGSHDSGS
NCTC8325        MKKCIKTLFLSIILVVMSGWYHSAHASDSLSKSPENWMSKLDDGKHLTEINIPGSHDSGS
Newman          MKKCIKTLFLSIILVVMSGWYHSAHASDSLSKSPENWMSKLDDGKHLTEINIPGSHDSGS
USA300_FPR3757  MKKCIKTLFLSIILVVMSGWYHSAHASDSLSKSPENWMSKLDDGKHLTEINIPGSHDSGS
                *****************.************************:.*******:********

COL             FTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLD
N315            FTLTDPVKSVWAKTQGKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLD
NCTC8325        FTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLD
Newman          FTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLD
USA300_FPR3757  FTLKDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLD
                ***.***********.********************************************

COL             DAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTL
N315            DAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTL
NCTC8325        DAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTL
Newman          DAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTL
USA300_FPR3757  DAKYYLSAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPTL
                ************************************************************

COL             KETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDK
N315            KETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDK
NCTC8325        KETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDK
Newman          KETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDK
USA300_FPR3757  KETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLNLKVQDEYKDYYDK
                ************************************************************

COL             KVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASHINPEIAKTIKANGKAR
N315            KVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASHINPEIAKTIKENGKAR
NCTC8325        KVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASHINPEIAKTIKANGKAR
Newman          KVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASHINPEIAKTIKANGKAR
USA300_FPR3757  KVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNSTYNYASHINPEIAKTIKANGKAR
                ****************************************************** *****

COL             TGWLIVDYAGYTWPGYDDIVSEIIDSNK
N315            TGWLIVDYAGYPWPGYDDIVSEIIDSNK
NCTC8325        TGWLIVDYAGYTWPGYDDIVSEIIDSNK
Newman          TGWLIVDYAGYTWPGYDDIVSEIIDSNK
USA300_FPR3757  TGWLIVDYAGYTWPGYDDIVSEIIDSNK
                ***********.****************

↑ Mark J White, Jeffrey M Boyd, Alexander R Horswill, William M Nauseef
Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils.
Infect Immun: 2014, 82(4);1559-71
[PubMed:24452683] [WorldCat.org] [DOI] (I p)Rebecca Goldstein, Jiongjia Cheng, Boguslaw Stec, Mary F Roberts
Structure of the S. aureus PI-specific phospholipase C reveals modulation of active site access by a titratable π-cation latched loop.
Biochemistry: 2012, 51(12);2579-87
[PubMed:22390775] [WorldCat.org] [DOI] (I p)

[1] Mark J White, Jeffrey M Boyd, Alexander R Horswill, William M Nauseef
Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils.
Infect Immun: 2014, 82(4);1559-71
[PubMed:24452683] [WorldCat.org] [DOI] (I p)Rebecca Goldstein, Jiongjia Cheng, Boguslaw Stec, Mary F Roberts
Structure of the S. aureus PI-specific phospholipase C reveals modulation of active site access by a titratable π-cation latched loop.
Biochemistry: 2012, 51(12);2579-87
[PubMed:22390775] [WorldCat.org] [DOI] (I p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]