⊟Summary[edit | edit source]

pan ID^?: SAUPAN000012000
symbol^?: gyrA
synonym:
description^?: DNA gyrase subunit A
- DNA gyrase subunit A
- DNA gyrase, A subunit
- DNA gyrase A subunit
- DNA topoisomerase (ATP-hydrolyzing) subunit A
- DNA topoisomerase (ATP-hydrolyzing) subunit A, GyrA
- DNA topoisomerase subunit A
strand^?: +
coordinates^?: 12832..15519
synteny block^?: BlockID0000090
occurrence^?: in 100% of 34 strains

gyrA : DNA gyrase subunit A ^[1]

• A crystal structure is available : 2XCQ

DNA gyrase is a dimer of heterodimers responsible for supercoiling and unraveling DNA supercoils. This is an essential process to fit the chromosome in the bacterial cell and conversely to unwind the origin to initiate chromosome replication.

⊟Orthologs[edit | edit source]

COL:

SACOL0006 (gyrA)

N315:

SA0006 (gyrA)

NCTC8325:

SAOUHSC_00006

Newman:

NWMN_0005 (gyrA)

USA300_FPR3757:

SAUSA300_0006 (gyrA)

04-02981:

SA2981_0006 (gyrA)

08BA02176:

C248_0006 (gyrA)

11819-97:

MS7_0006 (gyrA)

6850:

RSAU_000006 (gyrA)

71193:

ST398NM01_0006

ECT-R 2:

ECTR2_6 (gyrA)

ED133:

SAOV_0006 (gyrA)

ED98:

SAAV_0006 (gyrA)

HO 5096 0412:

SAEMRSA15_00060 (gyrA)

JH1:

SaurJH1_0006

JH9:

SaurJH9_0006

JKD6008:

SAA6008_00006 (gyrA)

JKD6159:

SAA6159_00006 (gyrA)

JSNZ:

JSNZ_000006 (gyrA)

LGA251:

SARLGA251_00060 (gyrA)

M013:

M013TW_0007

MRSA252:

SAR0006 (gyrA)

MSHR1132:

SAMSHR1132_00060

MSSA476:

SAS0006

Mu3:

SAHV_0006 (gyrA)

Mu50:

SAV0006 (gyrA)

MW2:

MW0006 (gyrA)

RF122:

SAB0006 (gyrA)

ST398:

SAPIG0006 (gyrA)

T0131:

SAT0131_00006

TCH60:

HMPREF0772_10462 (gyrA)

TW20:

SATW20_00060 (gyrA)

USA300_TCH1516:

USA300HOU_0006 (gyrA)

VC40:

SAVC_00030

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             ------MAELPQSRINERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLN
N315            ------MAELPQSRINERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLN
NCTC8325        ------MAELPQSRINERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLN
Newman          MKEELLMAELPQSRINERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLN
USA300_FPR3757  ------MAELPQSRINERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLN
                      ******************************************************

COL             EQGMTPDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMD
N315            EQGMTPDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMD
NCTC8325        EQGMTPDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMD
Newman          EQGMTPDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMD
USA300_FPR3757  EQGMTPDKSYKKSARIVGDVMGKYHPHGDLSIYEAMVRMAQDFSYRYPLVDGQGNFGSMD
                ***************************** ******************************

COL             GDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASG
N315            GDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASG
NCTC8325        GDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASG
Newman          GDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASG
USA300_FPR3757  GDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASG
                ************************************************************

COL             IAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILGKSGIRRAY
N315            IAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILGKSGIRRAY
NCTC8325        IAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILGKSGIRRAY
Newman          IAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILGKSGIRRAY
USA300_FPR3757  IAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILGKSGIRRAY
                ************************************************************

COL             ETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRD
N315            ETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRD
NCTC8325        ETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRD
Newman          ETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRD
USA300_FPR3757  ETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRD
                ************************************************************

COL             ETSLRTGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVH
N315            ETSLRTGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVH
NCTC8325        ETSLRTGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVH
Newman          ETSLRTGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVH
USA300_FPR3757  ETSLRTGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVH
                ************************************************************

COL             YLEHQKTVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQR
N315            YLEHQKTVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQR
NCTC8325        YLEHQKTVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQR
Newman          YLEHQKTVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQR
USA300_FPR3757  YLEHQKTVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQR
                ************************************************************

COL             FKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELEAILADEEVLLQLVRDELT
N315            FKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVLLQLVRDELT
NCTC8325        FKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELEAILADEEVLLQLVRDELT
Newman          FKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELEAILADEEVLLQLVRDELT
USA300_FPR3757  FKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELEAILADEEVLLQLVRDELT
                ******************************************:*****************

COL             EIRDRFGDDRRTEIQLGGFENLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRAQNRGGRG
N315            EIRDRFGDDRRTEIQLGGFEDLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRAQNRGGRG
NCTC8325        EIRDRFGDDRRTEIQLGGFEDLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRAQNRGGRG
Newman          EIRDRFGDDRRTEIQLGGFENLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRAQNRGGRG
USA300_FPR3757  EIRDRFGDDRRTEIQLGGFENLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRAQNRGGRG
                ********************:***************************************

COL             VQGMNTLEEDFVSQLVTLSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPVVNAIELE
N315            VQGMNTLEEDFVSQLVTLSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPVVNAIELE
NCTC8325        VQGMNTLEEDFVSQLVTLSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPVVNAIELE
Newman          VQGMNTLEEDFVSQLVTLSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPVVNAIELE
USA300_FPR3757  VQGMNTLEEDFVSQLVTLSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPVVNAIELE
                ************************************************************

COL             NDEVISTMIAVKDLESEDNFLVFATKRGVVKRSALSNFSRINRNGKIAISFREDDELIAV
N315            NDEVISTMIAVKDLESEDNFLVFATKRGVVKRSALSNFSRINRNGKIAISFREDDELIAV
NCTC8325        NDEVISTMIAVKDLESEDNFLVFATKRGVVKRSALSNFSRINRNGKIAISFREDDELIAV
Newman          NDEVISTMIAVKDLESEDNFLVFATKRGVVKRSALSNFSRINRNGKIAISFREDDELIAV
USA300_FPR3757  NDEVISTMIAVKDLESEDNFLVFATKRGVVKRSALSNFSRINRNGKIAISFREDDELIAV
                ************************************************************

COL             RLTSGQEDILIGTSHASLIRFPESTLRPLGRTATGVKGITLREGDEVVGLDVAHANSVDE
N315            RLTSGQEDILIGTSHASLIRFPESTLRPLGRTATGVKGITLREGDEVVGLDVAHANSVDE
NCTC8325        RLTSGQEDILIGTSHASLIRFPESTLRPLGRTATGVKGITLREGDEVVGLDVAHANSVDE
Newman          RLTSGQEDILIGTSHASLIRFPESTLRPLGRTATGVKGITLREGDEVVGLDVAHANSVDE
USA300_FPR3757  RLTSGQEDILIGTSHASLIRFPESTLRPLGRTATGVKGITLREGDEVVGLDVAHANSVDE
                ************************************************************

COL             VLVVTENGYGKRTPVNDYRLSNRGGKGIKTATITERNGNVVCITTVTGEEDLMIVTNAGV
N315            VLVVTENGYGKRTPVNDYRLSNRGGKGIKTATITERNGNVVCITTVTGEEDLMIVTNAGV
NCTC8325        VLVVTENGYGKRTPVNDYRLSNRGGKGIKTATITERNGNVVCITTVTGEEDLMIVTNAGV
Newman          VLVVTENGYGKRTPVNDYRLSNRGGKGIKTATITERNGNVVCITTVTGEEDLMIVTNAGV
USA300_FPR3757  VLVVTENGYGKRTPVNDYRLSNRGGKGIKTATITERNGNVVCITTVTGEEDLMIVTNAGV
                ************************************************************

COL             IIRLDVADISQNGRAAQGVRLIRLGDDQFVSTVAKVKEDAEDETNEDEQSTSTVSEDGTE
N315            IIRLDVADISQNGRAAQGVRLIRLGDDQFVSTVAKVKEDAEDETNEDEQSTSTVSEDGTE
NCTC8325        IIRLDVADISQNGRAAQGVRLIRLGDDQFVSTVAKVKEDAEDETNEDEQSTSTVSEDGTE
Newman          IIRLDVADISQNGRAAQGVRLIRLGDDQFVSTVAKVKEDAEDETNEDEQSTSTVSEDGTE
USA300_FPR3757  IIRLDVADISQNGRAAQGVRLIRLGDDQFVSTVAKVKEDAEDETNEDEQSTSTVSEDGTE
                ************************************************************

COL             QQREAVVNDETPGNAIHTEVIDSEENDEDGRIEVRQDFMDRVEEDIQQSSDEE--
N315            QQREAVVNDETPGNAIHTEVIDSEENDEDGRIEVRQDFMDRVEEDIQQSSDEDEE
NCTC8325        QQREAVVNDETPGNAIHTEVIDSEENDEDGRIEVRQDFMDRVEEDIQQSSDEE--
Newman          QQREAVVNDETPGNAIHTEVIDSEENDEDGRIEVRQDFMDRVEEDIQQSSDEE--
USA300_FPR3757  QQREAVVNDETPGNAIHTEVIDSEENDEDGRIEVRQDFMDRVEEDIQQSSDEE--
                ****************************************************:

↑ H Ito, H Yoshida, M Bogaki-Shonai, T Niga, H Hattori, S Nakamura
Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus.
Antimicrob Agents Chemother: 1994, 38(9);2014-23
[PubMed:7811012] [WorldCat.org] [DOI] (P p)S M Brockbank, P T Barth
Cloning, sequencing, and expression of the DNA gyrase genes from Staphylococcus aureus.
J Bacteriol: 1993, 175(11);3269-77
[PubMed:8388872] [WorldCat.org] [DOI] (P p)

[1] H Ito, H Yoshida, M Bogaki-Shonai, T Niga, H Hattori, S Nakamura
Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus.
Antimicrob Agents Chemother: 1994, 38(9);2014-23
[PubMed:7811012] [WorldCat.org] [DOI] (P p)S M Brockbank, P T Barth
Cloning, sequencing, and expression of the DNA gyrase genes from Staphylococcus aureus.
J Bacteriol: 1993, 175(11);3269-77
[PubMed:8388872] [WorldCat.org] [DOI] (P p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]