⊟Summary[edit | edit source]

pan ID^?: SAUPAN000011000
symbol^?: gyrB
synonym:
description^?: DNA gyrase subunit B
- DNA gyrase subunit B
- DNA gyrase, B subunit
- DNA topoisomerase (ATP-hydrolyzing) subunit B
- DNA gyrase B subunit
- DNA topoisomerase (ATP-hydrolyzing) subunit B, GyrB
- DNA topoisomerase subunit B
strand^?: +
coordinates^?: 10879..12813
synteny block^?: BlockID0000080
occurrence^?: in 100% of 34 strains

gyrB : DNA gyrase subunit B ^[1]

• A crystal structure is available : 4P8O

DNA gyrase is a dimer of heterodimers responsible for supercoiling and unraveling DNA supercoils. This is an essential process to fit the chromosome in the bacterial cell and conversely to unwind the origin to initiate chromosome replication.

⊟Orthologs[edit | edit source]

COL:

SACOL0005 (gyrB)

N315:

SA0005 (gyrB)

NCTC8325:

SAOUHSC_00005

Newman:

NWMN_0004 (gyrB)

USA300_FPR3757:

SAUSA300_0005 (gyrB)

04-02981:

SA2981_0005 (gyrB)

08BA02176:

C248_0005 (gyrB)

11819-97:

MS7_0005 (gyrB)

6850:

RSAU_000005 (gyrB)

71193:

ST398NM01_0005

ECT-R 2:

ECTR2_5 (gyrB)

ED133:

SAOV_0005 (gyrB)

ED98:

SAAV_0005 (gyrB)

HO 5096 0412:

SAEMRSA15_00050 (gyrB)

JH1:

SaurJH1_0005

JH9:

SaurJH9_0005

JKD6008:

SAA6008_00005 (gyrB)

JKD6159:

SAA6159_00005 (gyrB)

JSNZ:

JSNZ_000005 (gyrB)

LGA251:

SARLGA251_00050 (gyrB)

M013:

M013TW_0006

MRSA252:

SAR0005 (gyrB)

MSHR1132:

SAMSHR1132_00050

MSSA476:

SAS0005

Mu3:

SAHV_0005 (gyrB)

Mu50:

SAV0005 (gyrB)

MW2:

MW0005 (gyrB)

RF122:

SAB0005 (gyrB)

ST398:

SAPIG0005 (gyrB)

T0131:

SAT0131_00005

TCH60:

HMPREF0772_10463 (gyrB)

TW20:

SATW20_00050 (gyrB)

USA300_TCH1516:

USA300HOU_0005 (gyrB)

VC40:

SAVC_00025 (gyrB)

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MVTALSDVNNTDNYGAGQIQVLEGLEAARKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
N315            MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
NCTC8325        MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
Newman          MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
USA300_FPR3757  MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
                ***************************.********************************

COL             AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
N315            AGYANKIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
NCTC8325        AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
Newman          AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
USA300_FPR3757  AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
                *****:******************************************************

COL             GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
N315            GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
NCTC8325        GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
Newman          GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
USA300_FPR3757  GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
                ************************************************************

COL             GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
N315            GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
NCTC8325        GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
Newman          GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
USA300_FPR3757  GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
                ************************************************************

COL             NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
N315            NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
NCTC8325        NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
Newman          NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
USA300_FPR3757  NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
                ************************************************************

COL             TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
N315            TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
NCTC8325        TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
Newman          TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
USA300_FPR3757  TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
                ************************************************************

COL             DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
N315            DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
NCTC8325        DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
Newman          DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
USA300_FPR3757  DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
                ************************************************************

COL             CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
N315            CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
NCTC8325        CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
Newman          CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
USA300_FPR3757  CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
                ************************************************************

COL             MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
N315            MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
NCTC8325        MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
Newman          MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
USA300_FPR3757  MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
                ************************************************************

COL             QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
N315            QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
NCTC8325        QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
Newman          QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
USA300_FPR3757  QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
                ************************************************************

COL             RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
N315            RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
NCTC8325        RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
Newman          RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
USA300_FPR3757  RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
                ********************************************

↑ H Ito, H Yoshida, M Bogaki-Shonai, T Niga, H Hattori, S Nakamura
Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus.
Antimicrob Agents Chemother: 1994, 38(9);2014-23
[PubMed:7811012] [WorldCat.org] [DOI] (P p)S M Brockbank, P T Barth
Cloning, sequencing, and expression of the DNA gyrase genes from Staphylococcus aureus.
J Bacteriol: 1993, 175(11);3269-77
[PubMed:8388872] [WorldCat.org] [DOI] (P p)

[1] H Ito, H Yoshida, M Bogaki-Shonai, T Niga, H Hattori, S Nakamura
Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus.
Antimicrob Agents Chemother: 1994, 38(9);2014-23
[PubMed:7811012] [WorldCat.org] [DOI] (P p)S M Brockbank, P T Barth
Cloning, sequencing, and expression of the DNA gyrase genes from Staphylococcus aureus.
J Bacteriol: 1993, 175(11);3269-77
[PubMed:8388872] [WorldCat.org] [DOI] (P p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]