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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL_RS04860 [old locus tag: SACOL0948 ]
  • pan locus tag?: SAUPAN003046000
  • symbol: SACOL_RS04860
  • pan gene symbol?: —
  • synonym:
  • product: pyridine nucleotide-disulfide oxidoreductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SACOL_RS04860 [old locus tag: SACOL0948 ]
  • symbol: SACOL_RS04860
  • product: pyridine nucleotide-disulfide oxidoreductase
  • replicon: chromosome
  • strand: -
  • coordinates: 950401..951555
  • length: 1155
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_002951 (950401..951555) NCBI
  • BioCyc: SACOL_RS04860 BioCyc
  • MicrobesOnline: see SACOL0948

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGCATTGGACAATTATCGGCGGTGGCATACAGGGAACTGCAATCGCACAAAAACTATTA
    TCAAGCGGATTAACAACAGACCGATTAACAATCATTGACCCACACGAAACTTTTTGCCAA
    AGGTTTAACTCATATACAAATCGAATAGAAATGCCTTATTTAAGATCACCGATTGTACAT
    CACGTACATCCACAACCGTTCCATCTAAAACAATTCGCTAAACAGCACCAATATACAAAT
    GCTTTTTATGGTCCTTATCAACGACCTGAATTGACAATGTTTATGGATCATATTGCACAT
    GCTTCTAAACAATATCAATTAGAGGATTGCTTGGTTCAAGGTTTAGTTCAAACTTTAGAT
    AAACAAGAAGACAAATGGCATATCAAGTTAGAAGATGGACAAATTATCACTACAGATTGC
    GTCGTTATTGCAATAGGCAGTACAAATATTCCGTTTATGCCTGACATTTTAAAAGACAAA
    CAGAATGTAAATCATATCTTCGAGAAAGAACTTGATCAAGTAGTATATGATAAGACCGAT
    CATATCGTTGGTAGCGGCATTACTGCTGCACATCTTGCACTTAAATTGTTAAATCATGAT
    AACGATAAAAAGATTCATTTATGGCTAAATAAAGATATTGAAATACATGACTTTGATGCT
    GATCCTGGTTGGTTAGGTCCGAAAAATATGTCTTCATTTTTAAGTACTAAAAGCATGCCT
    GAAAGAAATGCCATTGTACAACGCGAACGTCATAAAGGATCAATGCCTCACGAACTGTAC
    TTACGCCTTAAAAAACATATTAAAAATGGTCGTATAAATGTGCATAAAACACCTATCACT
    CAAATTAGTGGTGGTGTAATTAACACTGAAAATGATTCTGTTCCATATCAACAGATTATG
    GTTGCAACTGGTTTTGAACAAGATTTTATGTCACAACCACTTATTAAGCAATTAATACAA
    AATTATGATGCACCTATCAACGAATGTAATTACCCTGTTATTTCCGAAAAATTAGAATGG
    ATACCAAATCTATTTGTCGCAGGATGCTTTGCAGACTTAGAATTAGGACCATTTGGTAGA
    AATGTTATGGGTGGCCGTAAAGCTGCCGAACGCATTGAACAAGCATTTCTAAAACTACAA
    CAATATAGCGCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1155

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SACOL_RS04860 [old locus tag: SACOL0948 ]
  • symbol: SACOL_RS04860
  • description: pyridine nucleotide-disulfide oxidoreductase
  • length: 384
  • theoretical pI: 7.07664
  • theoretical MW: 43955
  • GRAVY: -0.403906

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain (TIGR03197; HMM-score: 30.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family (TIGR01988; EC 1.14.13.-; HMM-score: 25.3)
    and 9 more
    lycopene cyclase family protein (TIGR01790; HMM-score: 21.5)
    putative histamine N-monooxygenase (TIGR04439; EC 1.14.13.-; HMM-score: 16.3)
    mycothione reductase (TIGR03452; EC 1.8.1.15; HMM-score: 13.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-polyprenyl-6-methoxyphenol 4-hydroxylase (TIGR01984; EC 1.14.13.-; HMM-score: 13.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine glycine oxidase ThiO (TIGR02352; EC 1.4.3.19; HMM-score: 12.3)
    Cellular processes Cellular processes Detoxification alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 12.1)
    Cellular processes Cellular processes Adaptations to atypical conditions alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 12.1)
    Unknown function Enzymes of unknown specificity flavoprotein, HI0933 family (TIGR00275; HMM-score: 11.7)
    Cellular processes Cellular processes Biosynthesis of natural products 2,3-diaminopropionate biosynthesis protein SbnB (TIGR03944; HMM-score: 11)
  • TheSEED: see SACOL0948
  • PFAM:
    NADP_Rossmann (CL0063) NAD_binding_9; FAD-NAD(P)-binding (PF13454; HMM-score: 45.6)
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 40.4)
    Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase (PF13738; HMM-score: 40)
    and 9 more
    NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 25.3)
    Lys_Orn_oxgnase; L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase (PF13434; HMM-score: 23)
    no clan defined MptE-like; 6-hydroxymethylpterin diphosphokinase MptE-like (PF01973; HMM-score: 21.2)
    NADP_Rossmann (CL0063) Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 18.5)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 17.5)
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 16.6)
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 13.4)
    TrkA_N; TrkA-N domain (PF02254; HMM-score: 12.8)
    GIDA; Glucose inhibited division protein A (PF01134; HMM-score: 11.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.7528
    • Cytoplasmic Membrane Score: 0.2289
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0181
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.02305
    • TAT(Tat/SPI): 0.002147
    • LIPO(Sec/SPII): 0.015907
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MHWTIIGGGIQGTAIAQKLLSSGLTTDRLTIIDPHETFCQRFNSYTNRIEMPYLRSPIVHHVHPQPFHLKQFAKQHQYTNAFYGPYQRPELTMFMDHIAHASKQYQLEDCLVQGLVQTLDKQEDKWHIKLEDGQIITTDCVVIAIGSTNIPFMPDILKDKQNVNHIFEKELDQVVYDKTDHIVGSGITAAHLALKLLNHDNDKKIHLWLNKDIEIHDFDADPGWLGPKNMSSFLSTKSMPERNAIVQRERHKGSMPHELYLRLKKHIKNGRINVHKTPITQISGGVINTENDSVPYQQIMVATGFEQDFMSQPLIKQLIQNYDAPINECNYPVISEKLEWIPNLFVAGCFADLELGPFGRNVMGGRKAAERIEQAFLKLQQYSA

⊟Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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