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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1126 [new locus tag: SACOL_RS05750 ]
  • pan locus tag?: SAUPAN003344000
  • symbol: SACOL1126
  • pan gene symbol?: ctaM
  • synonym:
  • product: hypothetical protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SACOL1126 [new locus tag: SACOL_RS05750 ]
  • symbol: SACOL1126
  • product: hypothetical protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1138352..1138813
  • length: 462
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGGGCGTTCCAATTTTACCAACGATTAGTACGACATGTATTGTCATTAGTGCAATTTTA
    ATTGCCATTGGTTGGAGACTTATTTGGAAAAGGGAAATAAATAAACACAAAAATGTTATG
    TTAGCTGCAGCTGTTTTTGCTTTAACTTTTTTCTTAATCTATGCAAGTAGAACGATTTTT
    ATCGGTAATACAGCATTTGGCGGACCAGCATCAATTAAGAAATATTATACGATTTTCTTA
    TTTTTCCACATTAATTTAGCAACAATTGGTGGTATTCTAGGCCTAGTTCAAATTATTACT
    GCATTTAAAGATAAATATAATGTACACCGCAAATTCGGGCCATTCGCTTCAGTTATATGG
    TTCTGTACTGCAATTACAGGTGTAGCAGTTTACTTATTATTATATGTATTATATCCAGGT
    GGAGAAACGACATCACTGATTAAAGCAACATTTGGTCATTAA
    60
    120
    180
    240
    300
    360
    420
    462

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SACOL1126 [new locus tag: SACOL_RS05750 ]
  • symbol: SACOL1126
  • description: hypothetical protein
  • length: 153
  • theoretical pI: 10.3728
  • theoretical MW: 16909.2
  • GRAVY: 0.870588

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED  :
    • Putative Heme biosynthesis related protein
  • PFAM:
    no clan defined DUF420; Protein of unknown function (DUF420) (PF04238; HMM-score: 128.5)
    and 5 more
    DUF2306; Predicted membrane protein (DUF2306) (PF10067; HMM-score: 23.1)
    DUF3169; Protein of unknown function (DUF3169) (PF11368; HMM-score: 12.7)
    TgpA_N; TgpA N-terminal domain (PF11992; HMM-score: 9.9)
    DHHC; DHHC palmitoyltransferase (PF01529; HMM-score: 8.6)
    DUF6404; Family of unknown function (DUF6404) (PF19942; HMM-score: 8.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 1
    • Cell wall & surface Score: 0
    • Extracellular Score: 0
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: -0.5
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002487
    • TAT(Tat/SPI): 0.000157
    • LIPO(Sec/SPII): 0.004627
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MGVPILPTISTTCIVISAILIAIGWRLIWKREINKHKNVMLAAAVFALTFFLIYASRTIFIGNTAFGGPASIKKYYTIFLFFHINLATIGGILGLVQIITAFKDKYNVHRKFGPFASVIWFCTAITGVAVYLLLYVLYPGGETTSLIKATFGH

⊟Experimental data[edit | edit source]

  • experimentally validated: PeptideAtlas
  • protein localization: Integral membrane [1] [2]
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
    A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
    PLoS One: 2009, 4(12);e8176
    [PubMed:19997597] [WorldCat.org] [DOI] (I e)
  2. ↑ Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
    The Staphylococcus aureus proteome.
    Int J Med Microbiol: 2014, 304(2);110-20
    [PubMed:24439828] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

Neal D Hammer, Lici A Schurig-Briccio, Svetlana Y Gerdes, Robert B Gennis, Eric P Skaar
CtaM Is Required for Menaquinol Oxidase aa3 Function in Staphylococcus aureus.
mBio: 2016, 7(4);
[PubMed:27406563] [WorldCat.org] [DOI] (I e)

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