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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_RS11185 [old locus tag: NWMN_1939 ]
  • pan locus tag?: SAUPAN005267000
  • symbol: NWMN_RS11185
  • pan gene symbol?: mroQ
  • synonym:
  • product: CPBP family intramembrane metalloprotease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: NWMN_RS11185 [old locus tag: NWMN_1939 ]
  • symbol: NWMN_RS11185
  • product: CPBP family intramembrane metalloprotease
  • replicon: chromosome
  • strand: +
  • coordinates: 2146558..2147301
  • length: 744
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_009641 (2146558..2147301) NCBI
  • BioCyc:
  • MicrobesOnline: see NWMN_1939

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGACAAGATTATGGGCATCATTGCTAACTGTTATTATTTATATATTGTCTCAATTTTTA
    CCGCTTCTCATTGTAAAAAAATTACCATTTGTACAATATAGTGGCATAGAACTGACTAAA
    GCAGTCATTTACATACAACTTGTTCTATTTTTAATCGCCGCCACGACGATTATTTTAATT
    AATTTAAAAATTAAAAATCCAACAAAATTAGAATTAGAAGTTAAAGAACCTAAAAAATAT
    ATCATTCCATGGGCATTGCTTGGATTTGCATTGGTAATGATTTATCAAATGGTAGTGAGC
    ATTGTATTAACGCAAATTTATGGTGGACAACAAGTAAGTCCTAATACAGAAAAGCTAATT
    ATTATTGCTCGAAAAATACCTATATTTATCTTCTTTGTATCTATTATTGGTCCTTTATTA
    GAAGAATATGTATTCAGAAAAGTAATCTTTGGAGAATTATTTAATGCGATTAAAGGTAAT
    CGTATCGTGGCATTTATTATTGCTACAACAGTAAGTTCATTAATATTTGCATTAGCACAT
    AATGATTTCAAATTTATTCCAGTTTATTTTGGTATGGGTGTCATTTTTTCATTAGCATAT
    GTTTGGACAAAACGGCTTGCTGTTCCAATTATTATCCATATGTTACAAAACGGATTTGTC
    GTTATATTCCAATTACTTAATCCTGAGGCTTTGAAAAAAGCCACGGAACAAGCGAATTTT
    ATATATCACATTTTTATTCCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    744

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: NWMN_RS11185 [old locus tag: NWMN_1939 ]
  • symbol: NWMN_RS11185
  • description: CPBP family intramembrane metalloprotease
  • length: 247
  • theoretical pI: 10.2821
  • theoretical MW: 28163.1
  • GRAVY: 0.940081

⊟Function[edit | edit source]

  • TIGRFAM:
    exosortase E/protease, VPEID-CTERM system (TIGR04162; EC 3.4.22.-; HMM-score: 28.4)
    and 1 more
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides CAAX prenyl protease-related protein (TIGR03008; HMM-score: 22.4)
  • TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
  • PFAM:
    Peptidase_U (CL0472) Abi; CAAX protease self-immunity (PF02517; HMM-score: 58.5)
    and 1 more
    no clan defined 2TM; 2TM domain (PF13239; HMM-score: 6.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 6
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007879
    • TAT(Tat/SPI): 0.000185
    • LIPO(Sec/SPII): 0.023779
  • predicted transmembrane helices (TMHMM): 6

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTRLWASLLTVIIYILSQFLPLLIVKKLPFVQYSGIELTKAVIYIQLVLFLIAATTIILINLKIKNPTKLELEVKEPKKYIIPWALLGFALVMIYQMVVSIVLTQIYGGQQVSPNTEKLIIIARKIPIFIFFVSIIGPLLEEYVFRKVIFGELFNAIKGNRIVAFIIATTVSSLIFALAHNDFKFIPVYFGMGVIFSLAYVWTKRLAVPIIIHMLQNGFVVIFQLLNPEALKKATEQANFIYHIFIP

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • data available for N315

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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