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NCBI: 06-JUL-2013
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus Newman
- locus tag: NWMN_0838 [new locus tag: NWMN_RS04725 ]
- pan locus tag?: SAUPAN003077000
- symbol: rexA
- pan gene symbol?: addA
- synonym:
- product: exonuclease RexA
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: NWMN_0838 [new locus tag: NWMN_RS04725 ]
- symbol: rexA
- product: exonuclease RexA
- replicon: chromosome
- strand: +
- coordinates: 928632..932285
- length: 3654
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 5332349 NCBI
- RefSeq: YP_001331872 NCBI
- BioCyc:
- MicrobesOnline: 3706387 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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3601ATGACAATTCCAGAGAAACCACAAGGCGTGATTTGGACTGACGCGCAATGGCAAAGTATT
TACGCAACTGGACAAGATGTACTTGTTGCAGCCGCGGCAGGTTCAGGTAAAACAGCTGTA
CTAGTTGAGCGTATTATCCAAAAGATTTTACGTGATGGCATTGATGTCGATCGACTTTTA
GTCGTAACGTTTACAAACTTAAGCGCACGTGAAATGAAGCATCGTGTAGACCAACGTATT
CAAGAGGCATCGATTGCTGATCCTGCAAATGCACACTTGAAAAACCAACGCATCAAAATT
CATCAAGCACAAATATCTACACTCCATAGTTTTTGCTTGAAATTAATTCAACAGCATTAT
GATGTATTAAATATTGACCCGAACTTTAGAACAAGCAGTGAAGCTGAAAATATTTTATTA
TTAGAACAAACGATAGATGAGGTCATAGAACAACATTACGATATCCTTGATCCTGCTTTT
ATTGAATTAACAGAGCAATTGTCTTCAGATAGAAGTGATGATCAGTTTCGAATGATTATT
AAACAATTGTATTTCTTTAGCGTTGCAAATCCAAATCCTACAAATTGGTTGGATCAATTG
GTGACACCATACGAAGAAGAAGCACAACAAGCGCAACTTATTCAACTACTAACAGACTTA
TCTAAAGTATTTATCACAGCTGCTTATGATGCTTTAAATAAGGCGTATGATTTGTTTAGT
ATGATGGATAGCGTCGATAAACATTTAGCTGTTATAGAAGATGAACGACGTTTAATGGGG
CGTGTTTTAGAAGGTGGCTTTATTGATATACCTTATTTAACTGGTCACGAATTTGGCGCG
CGTTTGCCTAATGTAACAGCGAAAATTAAAGAAGCAAATGAAATGATGGTCGATGCCTTA
GAAGATGCTAAACTTCAGTATAAAAAATATAAATCATTAATTGATAAAGTGAAGAGTGAT
TACTTTTCAAGAGAAGCTGATGATTTGAAAGCTGATATGCAACAATTGGCGCCACGAGTA
AAGTACCTTGCGCGTATTGTGAAAGATGTTATGTCAGAATTCAATCGAAAAAAGCGTAGC
AAAAATATTTTGGATTTTTCTGATTATGAACATTTTGCATTACAAATTTTAACTAATGAG
GATGGTTCGCCTTCAGAAATTGCCGAATCATACCGTCAACACTTCCAAGAAATATTGGTC
GATGAGTATCAAGATACGAACCGAGTTCAAGAGAAAATACTATCTTGCATCAAAACGGGT
GATGAACATAATGGTAATTTATTTATGGTTGGAGATGTTAAGCAATCCATTTATAAATTT
AGACAAGCTGATCCAAGTTTATTTATTGAAAAGTATCAACGCTTTACTATAGATGGAGAT
GGCACTGGACGTCGAATTGATTTGTCGCAAAACTTCCGTTCTCGAAAAGAAGTACTGTCA
ACGACTAACTATATATTCAAACATATGATGGATGAACAAGTCGGTGAAGTAAAATATGAT
GAAGCGGCACAGTTGTATTATGGTGCACCATATGATGAATCGGACCATCCAGTAAACTTA
AAAGTCCTTGTTGAAGCGGATCAAGAACATAGTGATTTAACTGGTAGTGAACAAGAAGCG
CATTTTATAGTAGAACAAGTTAAAGATATCTTAGAACATCAAAAAGTTTATGATATGAAA
ACAGGAAGCTATAGAAGTGCGACATACAAGGATATCGTTATTCTAGAACGCAGCTTTGGA
CAAGCTCGCAATTTACAACAAGCCTTTAAAAATGAAGATATTCCATTCCATGTGAATAGT
CGTGAAGGTTACTTTGAACAAACAGAAGTCCGCTTAGTATTATCATTTTTAAGAGCGATA
GATAATCCATTACAAGATATTTATTTAGTTGGGTTAATGCGCTCCGTTATATATCAGTTC
AAAGAAGACGAATTAGCTCAAATTAGAATATTGAGTCCAAATGATGACTACTTCTATCAA
TCGATTGTAAATTACATTAATGACGAAGCAGCAGATGCAATTTTAGTTGATAAATTAAAA
ATGTTTTTATCAGATATTCAAAGTTACCAACAATATAGTAAAGATCATCCGGTGTATCAG
TTAATTGATAAATTTTATAATGATCATTATGTTATTCAATACTTTAGTGGACTTATTGGT
GGACGTGGACGACGTGCAAATCTTTATGGTTTATTTAATAAAGCTATCGAGTTTGAGAAT
TCAAGTTTTAGAGGTTTATATCAATTTATTCGTTTTATCGATGAATTGATTGAAAGAGGC
AAAGATTTTGGTGAGGAAAATGTAGTTGGTCCAAACGATAATGTCGTTAGAATGATGACA
ATTCATAGTAGTAAAGGTCTAGAGTTTCCATTTGTCATTTATTCTGGATTGTCAAAAGAT
TTTAATAAACGTGATTTGAAACAACCAGTTATTTTAAATCAGCAATTTGGTCTCGGAATG
GATTATTTTGATGTGGATAAAGAAATGGCATTTCCATCTTTAGCTTCGGTTGCATATAGA
GCTGTTGCCGAAAAAGAACTTGTGTCAGAAGAAATGCGATTAGTCTATGTAGCATTAACA
AGAGCGAAAGAACAACTTTATTTAATTGGTAGAGTGAAAAATGATAAATCATTACTAGAA
CTAGAGCAATTGTCTATTTCTGGTGAGCACATTGCTGTCAATGAACGATTAACTTCACCA
AATCCGTTCCATCTTATTTATAGTATTTTATCTAAACATCAATCTGCGTCAATTCCAGAT
GATTTAAAATTTGAAAAAGATATAGCACAAATTGAAGATAGTAGTCGTCCGAATGTAAAT
ATTTCAATTGTGTACTTTGAAGATGTGTCTACAGAAACCATTTTAGATAATGATGAATAT
CGTTCGGTTAATCAATTAGAAACTATGCAAAATGGTAATGAAGATGTTAAAGCACAAATT
AAACACCAACTTGATTATCGATATCCATATGTAAATGATACTAAAAAGCCCTCAAAACAA
TCTGTTTCTGAATTGAAAAGACAATATGAAACAGAAGAAAGTGGCACAAGTTACGAACGA
GTAAGGCAATATCGTATCGGTTTTTCAACGTATGAACGACCTAAATTTCTAAGTGAACAA
GGTAAACGAAAAGCGAATGAAATTGGTACGTTAATGCATACAGTGATGCAACATTTACCA
TTCAAAAAAGAACGCATATCTGAAGTTGAGTTACATCAGTATATCGATGGATTAATCGAT
AAACATATTATCGAAGCAGATGCGAAAAAAGATATCCGTATGGATGAAATAATGACATTT
ATCAATAGTGAGTTATATTCGATTATTGCTGAAGCAGAGCAAGTTTATCGTGAATTACCG
TTTGTAGTTAACCAAGCATTAGTTGACCAATTGCCACAAGGAGACGAAGACGTCTCAATT
ATTCAAGGTATGATTGACTTAATCTTTGTTAAAGATGGTGTGCATTATTTTGTAGACTAT
AAAACCGATGCATTTAATCGTCGCCGTGGGATGACAGATGAAGAAATTGGTACACAATTA
AAAAATAAATATAAGATACAGATGAAATATTATCAAAATACGCTTCAAACGATTCTTAAT
AAAGAAGTTAAAGGTTATTTATACTTCTTCAAATTTGGTACATTGCAACTATAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: NWMN_0838 [new locus tag: NWMN_RS04725 ]
- symbol: RexA
- description: exonuclease RexA
- length: 1217
- theoretical pI: 4.94958
- theoretical MW: 141260
- GRAVY: -0.468036
⊟Function[edit | edit source]
- reaction: EC 3.6.4.12? ExPASyDNA helicase ATP + H2O = ADP + phosphateEC 3.1.-.-? ExPASy
- TIGRFAM: DNA metabolism DNA replication, recombination, and repair helicase-exonuclease AddAB, AddA subunit (TIGR02785; EC 3.1.-.-,3.6.4.12; HMM-score: 1455.2)and 5 moreDNA metabolism DNA replication, recombination, and repair double-strand break repair helicase AddA (TIGR02784; HMM-score: 214.8)DNA metabolism DNA replication, recombination, and repair exodeoxyribonuclease V, beta subunit (TIGR00609; EC 3.1.11.5; HMM-score: 212.5)DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase PcrA (TIGR01073; EC 3.6.4.12; HMM-score: 211.6)DNA metabolism DNA replication, recombination, and repair DNA helicase II (TIGR01075; EC 3.6.4.12; HMM-score: 195.1)DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase Rep (TIGR01074; EC 3.6.4.12; HMM-score: 190.1)
- TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
- PFAM: P-loop_NTPase (CL0023) UvrD-helicase; UvrD/REP helicase N-terminal domain (PF00580; HMM-score: 269.7)and 10 moreUvrD_C; UvrD-like helicase C-terminal domain (PF13361; HMM-score: 112.8)AAA_19; AAA domain (PF13245; HMM-score: 75.6)UvrD_C_2; UvrD-like helicase C-terminal domain (PF13538; HMM-score: 37.9)DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 28.8)PDDEXK (CL0236) PDDEXK_1; PD-(D/E)XK nuclease superfamily (PF12705; HMM-score: 25.8)P-loop_NTPase (CL0023) Viral_helicase1; Viral (Superfamily 1) RNA helicase (PF01443; HMM-score: 22.2)AAA_12; AAA domain (PF13087; HMM-score: 19.3)no clan defined Occludin_ELL; Occludin homology domain (PF07303; HMM-score: 16.5)P-loop_NTPase (CL0023) ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 16.4)no clan defined DUF2564; Protein of unknown function (DUF2564) (PF10819; HMM-score: 11.8)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors: Mg2+
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- LocateP: Intracellular
- Prediction by SwissProt Classification: Cytoplasmic
- Pathway Prediction: No pathway
- Intracellular possibility: 1
- Signal peptide possibility: -1
- N-terminally Anchored Score: 1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.008816
- TAT(Tat/SPI): 0.000928
- LIPO(Sec/SPII): 0.001407
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MTIPEKPQGVIWTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPANAHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQHYDILDPAFIELTEQLSSDRSDDQFRMIIKQLYFFSVANPNPTNWLDQLVTPYEEEAQQAQLIQLLTDLSKVFITAAYDALNKAYDLFSMMDSVDKHLAVIEDERRLMGRVLEGGFIDIPYLTGHEFGARLPNVTAKIKEANEMMVDALEDAKLQYKKYKSLIDKVKSDYFSREADDLKADMQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDGSPSEIAESYRQHFQEILVDEYQDTNRVQEKILSCIKTGDEHNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFTIDGDGTGRRIDLSQNFRSRKEVLSTTNYIFKHMMDEQVGEVKYDEAAQLYYGAPYDESDHPVNLKVLVEADQEHSDLTGSEQEAHFIVEQVKDILEHQKVYDMKTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQFKEDELAQIRILSPNDDYFYQSIVNYINDEAADAILVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVIQYFSGLIGGRGRRANLYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDFGEENVVGPNDNVVRMMTIHSSKGLEFPFVIYSGLSKDFNKRDLKQPVILNQQFGLGMDYFDVDKEMAFPSLASVAYRAVAEKELVSEEMRLVYVALTRAKEQLYLIGRVKNDKSLLELEQLSISGEHIAVNERLTSPNPFHLIYSILSKHQSASIPDDLKFEKDIAQIEDSSRPNVNISIVYFEDVSTETILDNDEYRSVNQLETMQNGNEDVKAQIKHQLDYRYPYVNDTKKPSKQSVSELKRQYETEESGTSYERVRQYRIGFSTYERPKFLSEQGKRKANEIGTLMHTVMQHLPFKKERISEVELHQYIDGLIDKHIIEADAKKDIRMDEIMTFINSELYSIIAEAEQVYRELPFVVNQALVDQLPQGDEDVSIIQGMIDLIFVKDGVHYFVDYKTDAFNRRRGMTDEEIGTQLKNKYKIQMKYYQNTLQTILNKEVKGYLYFFKFGTLQL
⊟Experimental data[edit | edit source]
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
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