PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: JSNZ_002588
• pan locus tag^?: SAUPAN006306000
• symbol: lqo
• pan gene symbol^?: lqo
• synonym:
• product: L-lactate dehydrogenase (quinone)

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: JSNZ_002588
• symbol: lqo
• product: L-lactate dehydrogenase (quinone)
• replicon: chromosome
• strand: -
• coordinates: 2593683..2595179
• length: 1497
• essential: unknown other strains

⊟Accession numbers

• Gene ID:
• RefSeq:
• BioCyc:
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  1321
  1381
  1441
  
  ATGGCTAAGTCTAATAGTAAAGACATCGTTTTAATTGGAGCCGGTGTACTTAGCACAACA
  TTTGGTTCAATGTTAAAAGAAATTGAGCCAGACTGGAATATCCACGTTTACGAACGCTTG
  GATCGTCCTGCAATCGAAAGTTCAAACGAAAGAAATAATGCTGGTACGGGTCATGCAGCA
  TTATGTGAGTTGAACTACACAGTTTTACAACCTGATGGTTCTATCGACATCGAAAAAGCG
  AAAGTGATTAACGAAGAGTTTGAGATTTCAAAACAATTCTGGGGTCACTTAGTGAAAAGC
  GGTAGCATCGAGAACCCAAGAGAATTTATCAATCCATTACCACACATCAGTTATGTTAGA
  GGTAAAAACAATGTTAAATTCTTAAAAGATCGTTACGAAGCGATGAAAGCTTTCCCTATG
  TTCGATAATATCGAATATACTGAAGACATCGAAGTAATGAAAAAATGGATTCCATTGATG
  ATGAAAGGCCGTGAAGATAACCCTGGTATCATGGCGGCAAGTAAAATTGACGAAGGTACA
  GATGTAAACTTCGGTGAATTAACACGTAAAATGGCTAAAAGCATTGAAGCACATCCAAAT
  GCTACAGTGCAATTTAACCATGAAGTTGTTGATTTTGAACAATTATCAAATGGTCAATGG
  GAAGTTACTGTTAAAAATCGCCTAACTGGTGAGAAATTCAAACAAGTAACTGACTATGTA
  TTCATCGGTGCTGGCGGTGGAGCGATTCCATTATTACAAAAAACAGGTATCCCTGAAAGT
  AAACATTTGGGTGGATTCCCTATCAGTGGTCAATTCTTAGCTTGTACAAACCCACAAGTT
  ATTGAACAACACGATGCCAAAGTTTATGGTAAAGAGCCACCTGGTACACCACCAATGACT
  GTACCTCATTTAGATACGCGTTACATTGATGGTCAAAGAACATTATTATTTGGACCATTT
  GCTAATGTTGGACCTAAATTCTTGAAAAATGGTTCTAACTTAGATTTATTCAAGTCTGTT
  AAAACATACAACATTACAACTTTATTAGCAGCAGCAGTTAAAAACTTACCTTTAATTAAA
  TACTCATTTGACCAAGTAATTATGACAAAAGAAGGTTGTATGAACCACTTACGTACTTTC
  TATCCAGAAGCACGTAATGAAGATTGGCAATTATACACTGCTGGTAAACGTGTACAAGTT
  ATCAAAGATACACCTGAACACGGTAAAGGATTCATCCAATTCGGTACAGAAGTGGTTAAC
  TCACAAGACCACACTGTAATTGCATTATTAGGTGAATCACCAGGGGCTTCAACTTCAGTT
  TCAGTTGCGTTAGAAGTATTAGAACGTAACTTCCCTGAATACAAAACTGAATGGGCACCT
  AAAATTAAGAAAATGATTCCATCATACGGTGAATCATTAATTGAAGACGAAAAATTAATG
  AGAAAAATCCGTAAACAAACTTCAAAAGACTTAGAATTAGGTTACTACGAAAACTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1320
  1380
  1440
  1497
  

⊟Protein

⊟General

• locus tag: JSNZ_002588
• symbol: Lqo
• description: L-lactate dehydrogenase (quinone)
• length: 498
• theoretical pI: 6.52415
• theoretical MW: 55998.5
• GRAVY: -0.430924

⊟Function

• reaction:
  EC 1.1.5.-?  ExPASy
• TIGRFAM:
  Metabolism Energy metabolism TCA cycle malate dehydrogenase (acceptor) (TIGR01320; EC 1.1.5.4; HMM-score: 633.5)
  and 2 more
  Cellular processes Cellular processes Detoxification CoA-disulfide reductase (TIGR03385; EC 1.8.1.14; HMM-score: 16.2)
  conserved hypothetical protein (TIGR04540; HMM-score: 12.8)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  NADP_Rossmann (CL0063) Mqo; Malate:quinone oxidoreductase (Mqo) (PF06039; HMM-score: 722.1)
  and 1 more
  DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 26.8)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cellwall
  • Cytoplasmic Score: 0.01
  • Cytoplasmic Membrane Score: 0.53
  • Cellwall Score: 8.75
  • Extracellular Score: 0.7
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.2025
  • Cytoplasmic Membrane Score: 0.644
  • Cell wall & surface Score: 0.0004
  • Extracellular Score: 0.1531
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.093464
  • TAT(Tat/SPI): 0.007823
  • LIPO(Sec/SPII): 0.022182
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq:
• UniProt:

⊟Protein sequence

• MAKSNSKDIVLIGAGVLSTTFGSMLKEIEPDWNIHVYERLDRPAIESSNERNNAGTGHAALCELNYTVLQPDGSIDIEKAKVINEEFEISKQFWGHLVKSGSIENPREFINPLPHISYVRGKNNVKFLKDRYEAMKAFPMFDNIEYTEDIEVMKKWIPLMMKGREDNPGIMAASKIDEGTDVNFGELTRKMAKSIEAHPNATVQFNHEVVDFEQLSNGQWEVTVKNRLTGEKFKQVTDYVFIGAGGGAIPLLQKTGIPESKHLGGFPISGQFLACTNPQVIEQHDAKVYGKEPPGTPPMTVPHLDTRYIDGQRTLLFGPFANVGPKFLKNGSNLDLFKSVKTYNITTLLAAAVKNLPLIKYSFDQVIMTKEGCMNHLRTFYPEARNEDWQLYTAGKRVQVIKDTPEHGKGFIQFGTEVVNSQDHTVIALLGESPGASTSVSVALEVLERNFPEYKTEWAPKIKKMIPSYGESLIEDEKLMRKIRKQTSKDLELGYYEN

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell: data available for COL
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: data available for COL

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications