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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002292
  • pan locus tag?: SAUPAN005805000
  • symbol: JSNZ_002292
  • pan gene symbol?: glvR
  • synonym:
  • product: MurR/RpiR family transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002292
  • symbol: JSNZ_002292
  • product: MurR/RpiR family transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 2288403..2289167
  • length: 765
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGTTTTTAGATGAACACATTAATCGAAACTTTGATAAACTTAATGATAATGATTTACAT
    ATCGCTCACTTTATCAATACACATATAGATGAATGTAAAAATATGAAAATACAAGATTTA
    GCGCAATTCACACATGCCTCGAATGCAACCATTCACAGATTTACACGCAAATTAGGTTTT
    GACGGTTATAGTGATTTTAAATCGTACCTTAAATTTGAAAGTAATAAGACACACCAATTA
    CCTTCTAACTCTATCGATAGTTTCAAACAAGAAATCGATAGTACATTCAGTTATATAGAA
    CGCGTTGATTACCAGCTTCTTACTGAAAAAATGCATACAGCTTCAACAATATATTTGTAT
    GGTACAGGGCGTGCACAGTTAAACGTTGCTTCAGAGGCACAGCGTATACTGTTAACGTTA
    CATAATCATGTCATTGTACTTCATGATGAACATGAACTTAAAATGATTTTGAACAAGAGT
    GAACCTAATGATTTATTCTTTATTATTTCATTATCAGGTGAAACACATGAATTATTAGAA
    GTAACAAACTTGCTTCAACTTAGACAAAAATACTTTATTTCTGTTACTACAATGAAAGAT
    AATACCCTTGCTCAAAAAGCAAATTACAACGTCTATGTATCCAGTAACACATTCTACTTA
    ACTGATGGTACAGACTATTCTAGCTTCATCAGTTATCATATATTCTTTGAAACACTTGTA
    AGAAAATATAATGAGTATTTACTACATAATGATATTTCAAATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    765

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_002292
  • symbol: JSNZ_002292
  • description: MurR/RpiR family transcriptional regulator
  • length: 254
  • theoretical pI: 6.33997
  • theoretical MW: 29785.2
  • GRAVY: -0.419291

⊟Function[edit | edit source]

  • TIGRFAM:
    6-phospho 3-hexuloisomerase (TIGR03127; EC 5.3.-.-; HMM-score: 48.7)
    and 4 more
    Metabolism Energy metabolism Sugars sugar isomerase, KpsF/GutQ family (TIGR00393; HMM-score: 25.7)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 19.5)
    Metabolism Central intermediary metabolism Amino sugars glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 19.5)
    bifunctional phosphoglucose/phosphomannose isomerase (TIGR02128; EC 5.3.1.9; HMM-score: 12.8)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    HTH (CL0123) HTH_6; Helix-turn-helix domain, rpiR family (PF01418; HMM-score: 64.3)
    SIS (CL0067) SIS; SIS domain (PF01380; HMM-score: 63.8)
    and 3 more
    SIS_2; SIS domain (PF13580; HMM-score: 14.2)
    HTH (CL0123) HTH_IclR; IclR helix-turn-helix domain (PF09339; HMM-score: 13.2)
    MarR; MarR family (PF01047; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effector: Maltose-6-phosphate
  • gene regulated by GlvR*, TF important in Maltose utilizationsee RegPrecise for N315
    activation
    glvC*

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9368
    • Cytoplasmic Membrane Score: 0.0438
    • Cell wall & surface Score: 0.0005
    • Extracellular Score: 0.019
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004508
    • TAT(Tat/SPI): 0.000748
    • LIPO(Sec/SPII): 0.00093
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFLDEHINRNFDKLNDNDLHIAHFINTHIDECKNMKIQDLAQFTHASNATIHRFTRKLGFDGYSDFKSYLKFESNKTHQLPSNSIDSFKQEIDSTFSYIERVDYQLLTEKMHTASTIYLYGTGRAQLNVASEAQRILLTLHNHVIVLHDEHELKMILNKSEPNDLFFIISLSGETHELLEVTNLLQLRQKYFISVTTMKDNTLAQKANYNVYVSSNTFYLTDGTDYSSFISYHIFFETLVRKYNEYLLHNDISN

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Carbon catabolism;  regulation predicted or transferred from N315 and NCTC 8325  [1]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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