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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002284
  • pan locus tag?: SAUPAN005796000
  • symbol: JSNZ_002284
  • pan gene symbol?: —
  • synonym:
  • product: amino acid permease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002284
  • symbol: JSNZ_002284
  • product: amino acid permease
  • replicon: chromosome
  • strand: -
  • coordinates: 2281483..2282862
  • length: 1380
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGGAGAACAATGAACTACAAAGGGGATTGAGTGCCCGTCAAATTCAAATGATTGCACTT
    GGTGGTACGATTGGCGTGGGGCTTTTCATGGGTGCCACAAGTACAATTAAATGGACAGGC
    CCATCAGTTATCCTTGCATATTTAATTGCGGGTATCTTTTTATTTTTAATCATGAGAGCA
    ATGGGGGAAATGATTTATTTAAACCCTACAACAGGATCATTTGCAACATTTGCAAGTGAT
    TATATACATCCTGCAGCAGGTTATATGACAGCATGGAGTAATATATTCCAATGGATTGTA
    GTTGGTATGAGTGAGGTCATCGCAGTAGGAGAATATATGAAGTTTTGGTTCCCGGAATTG
    CCAACTTGGATTCCTGGTGTTATTGCTATTTTATTATTAATGGCAGCGAATTTATTCTCG
    GTAAAAGCGTTTGGAGAATTTGAATTTTGGTTTGCTTTAATTAAAGTTGTAACAATTATT
    TTAATGATTATTGCTGGTTTTGGTCTTATTTTCTTTGGTTTTGGAAATGGTAGCCATGCG
    GTAGGTATTTCTAATCTATGGACAAATGGCGGATTTATGCCAAATGGTATTGTTGGTTTC
    TTCTTTGCATTATCAATTGTAATTGGTTCATACCAAGGTGTGGAACTGATAGGTATTACG
    GCAGGTGAAACTAAAGATCCTCAGAAAAATATCGTTAAAGCAGTGAATGGTGTTATCTGG
    AGAATTTTAATTTTCTATTTAGGCGCTATTTTTGTTATTGTTTCAGTGTATCCTTGGAAT
    CAATTAGGAGACATTGGAAGTCCGTTTGTTGCAACATTTGCTAAAATCGGTATTACATTT
    GCAGCTGGATTAATTAACTTTGTTGTATTAACTGCAGCAATGTCAGGATGTAACTCAGGT
    ATTTTCAGTGCGAGTCGTATGATTTATACACTTGCTCATAAAGGTGAAATGCCGAAAATA
    TTTACTAAAATCATGAGAAATGGTGTACCATTGTACACTGTTGTAGCAGTATCTCTTGGT
    ATTTTAATTGGTGCTTTATTAAACGTAATTTTACCTTTATATATCGATGGAGCGAAGAGT
    ATTTTCGTATACGTTTATAGTGCGTCTATTTTACCAGGTATGATTCCTTGGTTTATGATT
    TTATTCAGTCATTTACGTTTTAGAAAATTACACCCTGAAGAATTGGAAGGTCACCCATTC
    AAAATGCCTGGTGGCGCAGTAACTAACTATTTAACAATCTTATTCTTAATATTAGTATTG
    GTTGGTATGGTATTTAATGTTGAAACTAGAATATCAGTGCTTATTGGTGTCATCTTCTTA
    ACGATTGTAACGATTTATTATTTTATTAGATATAATAAAAATAATGTAAAAGCAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_002284
  • symbol: JSNZ_002284
  • description: amino acid permease
  • length: 459
  • theoretical pI: 9.70264
  • theoretical MW: 50381.9
  • GRAVY: 0.869717

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Amino acids, peptides and amines GABA permease (TIGR01773; HMM-score: 357.2)
    and 7 more
    Metabolism Transport and binding proteins Amino acids, peptides and amines amino acid permease (yeast) (TIGR00913; HMM-score: 272.7)
    Metabolism Transport and binding proteins Amino acids, peptides and amines amino acid transporter (TIGR00909; HMM-score: 113.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines ethanolamine permease (TIGR00908; HMM-score: 106.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines cationic amino acid transport permease (TIGR00906; HMM-score: 70.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines L-type amino acid transporter (TIGR00911; HMM-score: 41.8)
    histidine-histamine antiporter (TIGR04298; HMM-score: 24.1)
    putative glutamate/gamma-aminobutyrate antiporter (TIGR03813; HMM-score: 21.7)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    APC (CL0062) AA_permease; Amino acid permease (PF00324; HMM-score: 372)
    and 2 more
    AA_permease_2; Amino acid permease (PF13520; HMM-score: 119.6)
    no clan defined PrgI; PrgI family protein (PF12666; HMM-score: 18.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 12
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9998
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0002
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007743
    • TAT(Tat/SPI): 0.010608
    • LIPO(Sec/SPII): 0.081993
  • predicted transmembrane helices (TMHMM): 11

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MENNELQRGLSARQIQMIALGGTIGVGLFMGATSTIKWTGPSVILAYLIAGIFLFLIMRAMGEMIYLNPTTGSFATFASDYIHPAAGYMTAWSNIFQWIVVGMSEVIAVGEYMKFWFPELPTWIPGVIAILLLMAANLFSVKAFGEFEFWFALIKVVTIILMIIAGFGLIFFGFGNGSHAVGISNLWTNGGFMPNGIVGFFFALSIVIGSYQGVELIGITAGETKDPQKNIVKAVNGVIWRILIFYLGAIFVIVSVYPWNQLGDIGSPFVATFAKIGITFAAGLINFVVLTAAMSGCNSGIFSASRMIYTLAHKGEMPKIFTKIMRNGVPLYTVVAVSLGILIGALLNVILPLYIDGAKSIFVYVYSASILPGMIPWFMILFSHLRFRKLHPEELEGHPFKMPGGAVTNYLTILFLILVLVGMVFNVETRISVLIGVIFLTIVTIYYFIRYNKNNVKAK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CcpA regulon, CodY (repression) regulon
    CcpA(TF)important in Carbon catabolism;  regulation predicted or transferred from N315 and NCTC 8325  [1]
    CodY(TF)important in Amino acid metabolism;  regulation predicted or transferred from N315 and NCTC 8325  [1]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.0 1.1 Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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