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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002088
  • pan locus tag?: SAUPAN005421000
  • symbol: JSNZ_002088
  • pan gene symbol?: pyrG
  • synonym:
  • product: CTP synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002088
  • symbol: JSNZ_002088
  • product: CTP synthase
  • replicon: chromosome
  • strand: -
  • coordinates: 2099292..2100902
  • length: 1611
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    ATGACAAAATTTATTTTTGTAACAGGTGGCGTAGTTTCATCATTAGGGAAGGGTATTACA
    GCATCTTCTCTAGGTAGATTATTAAAAGATAGAGGTCTAAATGTAACAATTCAAAAATTC
    GATCCATACTTAAATGTTGACCCAGGTACAATGAGTCCTTATCAACATGGTGAAGTATTC
    GTAACGGATGATGGTGCAGAAACTGACCTAGACTTAGGACATTACGAAAGATTTATTGAT
    ATTAATTTAAACAAGTTTTCAAATGTGACAGCCGGTAAAGTGTATTCACACGTATTGAAA
    AAAGAACGTCGTGGTGATTACTTAGGCGGAACAGTTCAAGTTATTCCGCATATTACAAAT
    GAAATTAAAGAACGTTTATTACTTGCAGGGGAAAGTACGAATGCAGACGTTGTTATCACT
    GAAATTGGCGGTACAACAGGTGATATTGAGTCATTACCGTTTATTGAAGCGATTCGTCAA
    ATTCGTAGCGATTTAGGTAGAGAAAATGTTATGTATGTTCACTGTACATTACTGCCTTAT
    ATTAAAGCTGCTGGAGAAATGAAAACGAAGCCAACACAACATAGTGTTAAAGAATTACGA
    GGCTTAGGTATTCAACCAGACTTAATCGTTGTAAGAACTGAATATGAAATGACACAAGAT
    TTAAAAGATAAAATTGCATTATTCTGTGACATTAATAAAGAAAGTGTTATTGAATGTCGT
    GATGCAGACTCTTTATACGAAATTCCATTACAATTAAGCCAACAAAATATGGATGATATC
    GTTATTAAACGTTTACAATTAAACGCGAAATATGAAACACAGCTTGATGAATGGAAACAG
    TTGTTAGATATCGTTAATAATTTAGATGGTAAAATTACAATTGGTTTAGTAGGTAAATAT
    GTTAGCTTACAAGATGCATATTTATCAGTTGTTGAATCATTGAAACATGCTGGATATCCT
    TTTGCCAAAGATATTGACATTAGATGGATTGATTCAAGTGAAGTAACAGATGAAAATGCA
    GCCGAATACCTTGCAGATGTCGACGGTATTTTAGTACCAGGTGGATTTGGTTTCCGTGCA
    AGTGAAGGTAAAATTAGTGCAACTAAGTATGCTAGAGAAAACAATGTACCATTCTTTGGT
    ATTTGTTTAGGAATGCAACTTGCAACAGTTGAATTTTCAAGAAACGTATTAGGCCTTGAA
    GGCGCACATTCAGCTGAATTAGACCCAGCAACACCATACCCAATTATAGATTTATTACCA
    GAACAAAAAGATATCGAAGATTTAGGTGGTACATTACGCTTAGGCTTATATCCATGTTCT
    ATTAAAGAAGGTACATTGGCACAAGATGTTTATGGTAAAGCGGAAATTGAAGAAAGACAT
    CGTCATCGTTATGAATTTAATAATGACTATAGAGAACAATTAGAAGCAAATGGTATGGTG
    ATTTCTGGTACAAGTCCAGATGGACGTTTAGTAGAAATGGTAGAGATTCCGACAAATGAT
    TTCTTTATTGCTTGTCAATTCCACCCAGAATTCTTATCTAGACCAAATCGTCCGCACCCG
    ATTTTTAAATCATTTATTGAAGCTTCATTAAAATATCAACAAAATAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1611

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_002088
  • symbol: JSNZ_002088
  • description: CTP synthase
  • length: 536
  • theoretical pI: 4.75985
  • theoretical MW: 59979.7
  • GRAVY: -0.26847

⊟Function[edit | edit source]

  • reaction:
    EC 6.3.4.2?  ExPASy
    CTP synthase (glutamine hydrolyzing) ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis CTP synthase (TIGR00337; EC 6.3.4.2; HMM-score: 849.2)
    and 4 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis carbamoyl-phosphate synthase, small subunit (TIGR01368; EC 6.3.5.5; HMM-score: 29.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis GMP synthase (glutamine-hydrolyzing), N-terminal domain (TIGR00888; EC 6.3.5.2; HMM-score: 25.9)
    Metabolism Amino acid biosynthesis Histidine family imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (TIGR01855; EC 2.4.2.-; HMM-score: 22.9)
    aminodeoxychorismate synthase (TIGR01823; EC 2.6.1.85; HMM-score: 14.4)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    P-loop_NTPase (CL0023) CTP_synth_N; CTP synthase N-terminus (PF06418; HMM-score: 430.6)
    and 4 more
    Glutaminase_I (CL0014) GATase; Glutamine amidotransferase class-I (PF00117; HMM-score: 139.4)
    Peptidase_C26; Peptidase C26 (PF07722; HMM-score: 39.1)
    P-loop_NTPase (CL0023) CbiA; CobQ/CobB/MinD/ParA nucleotide binding domain (PF01656; HMM-score: 15.1)
    Glutaminase_I (CL0014) DJ-1_PfpI; DJ-1/PfpI family (PF01965; HMM-score: 13.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8964
    • Cytoplasmic Membrane Score: 0.0123
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0909
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.107719
    • TAT(Tat/SPI): 0.010687
    • LIPO(Sec/SPII): 0.063485
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTKFIFVTGGVVSSLGKGITASSLGRLLKDRGLNVTIQKFDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTAGKVYSHVLKKERRGDYLGGTVQVIPHITNEIKERLLLAGESTNADVVITEIGGTTGDIESLPFIEAIRQIRSDLGRENVMYVHCTLLPYIKAAGEMKTKPTQHSVKELRGLGIQPDLIVVRTEYEMTQDLKDKIALFCDINKESVIECRDADSLYEIPLQLSQQNMDDIVIKRLQLNAKYETQLDEWKQLLDIVNNLDGKITIGLVGKYVSLQDAYLSVVESLKHAGYPFAKDIDIRWIDSSEVTDENAAEYLADVDGILVPGGFGFRASEGKISATKYARENNVPFFGICLGMQLATVEFSRNVLGLEGAHSAELDPATPYPIIDLLPEQKDIEDLGGTLRLGLYPCSIKEGTLAQDVYGKAEIEERHRHRYEFNNDYREQLEANGMVISGTSPDGRLVEMVEIPTNDFFIACQFHPEFLSRPNRPHPIFKSFIEASLKYQQNK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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