PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: JSNZ_002085
• pan locus tag^?: SAUPAN005416000
• symbol: JSNZ_002085
• pan gene symbol^?: murA2
• synonym:
• product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: JSNZ_002085
• symbol: JSNZ_002085
• product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
• replicon: chromosome
• strand: -
• coordinates: 2095859..2097118
• length: 1260
• essential: unknown other strains

⊟Accession numbers

• Gene ID:
• RefSeq:
• BioCyc:
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  
  ATGGCTCAAGAGGTAATAAAAATAAGAGGTGGACGCACACTAAATGGGGAAGTTAATATC
  AGTGGCGCGAAAAACAGTGCTGTAGCTATCATTCCTGCAACATTATTAGCTCAAGGACAT
  GTGAAATTAGAAGGGTTACCGCAAATCTCTGATGTTAAAACTTTAGTGAGTTTATTAGAA
  GATTTAAATATTAAGGCATCACTAAATGGTACGGAATTAGAAGTTGATACAACTGAAATA
  CAAAATGCTGCATTACCAAATAATAAAGTTGAATCATTACGTGCTTCATACTATATGATG
  GGTGCCATGTTAGGTAGATTTAAAAAATGTGTGATTGGTTTACCGGGAGGATGTCCACTT
  GGGCCACGTCCAATTGATCAACATATTAAAGGATTTAAAGCTTTAGGTGCTGAAATTGAT
  GAATCAAGCACGACATCAATGAAAATTGAAGCTAAAGAATTAAAAGGTGCGCATATTTTT
  CTAGATATGGTTAGCGTAGGTGCAACAATTAACATTATGCTAGCTGCAGTTTATGCAACA
  GGACAAACTGTAATTGAAAATGCTGCTAAAGAACCGGAAGTAGTTGATGTTGCTAACTTC
  TTAACAAGTATGGGAGCTAATATTAAGGGAGCGGGTACATCAACAATTAAAATCAATGGT
  GTCAAAGAATTACATGGTTCTGAGTATCAAGTTATACCTGATAGAATTGAAGCAGGCACA
  TATATGTGTATCGCTGCAGCATGTGGAGAAAATGTTATATTAAATAATATTGTTCCGAAA
  CATGTAGAAACATTAACTGCTAAATTTAGTGAATTAGGTGTGAATGTTGATGTAAGAGAC
  GAAAGAATTCGCATCAATAATAATGCGCCATATCAATTTGTTGATATTAAAACACTAGTA
  TATCCAGGTTTTGCTACTGATTTGCAACAGCCTATTACACCATTATTATTTATGGCAAAT
  GGTCCTTCATTTGTAACTGATACGATTTATCCAGAGCGTTTTAAACATGTTGAAGAATTA
  AAGCGCATGGGTGCAAATATTGAAGTTGACGAAGGCACAGCAACGATAAAACCATCAACA
  TTACATGGTGCTGAAGTTTATGCTAGCGATTTAAGAGCAGGAGCTTGTTTAATTATTGCT
  GGTTTAATTGCTGAGGGTGTAACTACAATTTACAATGTAAAACATATTTATAGAGGTTAT
  ACAGATATTGTAGAACACTTAAAAGCTTTAGGTGCGGATATTTGGACGGAAACTGTATAG
  60
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  240
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  1020
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  1140
  1200
  1260
  

⊟Protein

⊟General

• locus tag: JSNZ_002085
• symbol: JSNZ_002085
• description: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
• length: 419
• theoretical pI: 5.46141
• theoretical MW: 45074.7
• GRAVY: 0.072315

⊟Function

• reaction:
  EC 2.5.1.7?  ExPASy
  UDP-N-acetylglucosamine 1-carboxyvinyltransferase Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
• TIGRFAM:
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylglucosamine 1-carboxyvinyltransferase (TIGR01072; EC 2.5.1.7; HMM-score: 526.9)
  and 1 more
  Metabolism Amino acid biosynthesis Aromatic amino acid family 3-phosphoshikimate 1-carboxyvinyltransferase (TIGR01356; EC 2.5.1.19; HMM-score: 87.8)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  EPT_RTPC (CL0290) EPSP_synthase; EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) (PF00275; HMM-score: 318.9)
  and 1 more
  NADP_Rossmann (CL0063) ADH_zinc_N; Zinc-binding dehydrogenase (PF00107; HMM-score: 18.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.8855
  • Cytoplasmic Membrane Score: 0.065
  • Cell wall & surface Score: 0.0022
  • Extracellular Score: 0.0473
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.018228
  • TAT(Tat/SPI): 0.001295
  • LIPO(Sec/SPII): 0.001594
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq:
• UniProt:

⊟Protein sequence

• MAQEVIKIRGGRTLNGEVNISGAKNSAVAIIPATLLAQGHVKLEGLPQISDVKTLVSLLEDLNIKASLNGTELEVDTTEIQNAALPNNKVESLRASYYMMGAMLGRFKKCVIGLPGGCPLGPRPIDQHIKGFKALGAEIDESSTTSMKIEAKELKGAHIFLDMVSVGATINIMLAAVYATGQTVIENAAKEPEVVDVANFLTSMGANIKGAGTSTIKINGVKELHGSEYQVIPDRIEAGTYMCIAAACGENVILNNIVPKHVETLTAKFSELGVNVDVRDERIRINNNAPYQFVDIKTLVYPGFATDLQQPITPLLFMANGPSFVTDTIYPERFKHVEELKRMGANIEVDEGTATIKPSTLHGAEVYASDLRAGACLIIAGLIAEGVTTIYNVKHIYRGYTDIVEHLKALGADIWTETV

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell: data available for COL
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: data available for COL

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications