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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_001985
  • pan locus tag?: SAUPAN005268000
  • symbol: JSNZ_001985
  • pan gene symbol?: sdrH
  • synonym:
  • product: SdrH family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_001985
  • symbol: JSNZ_001985
  • product: SdrH family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1999446..2000705
  • length: 1260
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGTCATATCATTGGTTTAAGAAAATGTTACTTTCAACAAGTATTTTAATTTTAAGTAGT
    AGTAGTTTAGGGCTTGCAACGCACACAGTTGAAGCAAAGGATAACTTAAATGGAGAAAAA
    CCAACTACTAATTTGAATCATAATATAACTTCACCATCAGTAAATAGTGAAATGAATAAT
    AATGAGACTGGGACACCTCACGAATCAAATCAAACGGGTAATGAAGGAACAGGTTCGAAT
    AGTCGTGATGCTAATCCTGATTCGAATAATGTGAAGCCAGACTCAAACAACCAAAACCCA
    AGTACAGATTCAAAACCAGACCCAAATAACCAAAACCCAAGTCCGAATCCAAAACCAGAT
    CCAGATAACCCGAAACCAAAACCGGATCCAAAACCAGACCCAGATAAACCAAAGCCAAAT
    CCGGATCCAAAACCAGATCCAGATAACCCGAAACCAAATCCAGATCCAAAACCAGACCCA
    GATAACCCGAAACCAAAACCGGATCCAAAACCAGACCCAGATAAACCAAAGCCAAATCCG
    AATCCAAAACCAGACCCTAATAAGTCAAATCCTAACCCGTCACCAGATCCCAATCAACCT
    GGGGATTCCAATCATTCTGGTGGCTCGAAAAATGGGGGAACATGGAACCCAAATGCTTCA
    GATGGATCTAATCAAGGTCAATGGCAACCAAATGGAAATCAAGGAAACTCACAAAATCCT
    ACTGGTAATGATTTTGTGTCCCAACGATTTTTAGCCTTGGCGAATGGGGCTTACAAGTAT
    AATCCGTATATTTTAAATCAAATTAATAAGTTGGGCAAAGATTATGGAGAAGTTACTGAT
    GAAGACATTTATAATATTATTCGCAAACAAAACTTCAGCGGAAATGCTTATTTAAATGGA
    TTACAACAACAATCGAATTACTTTAGATTCCAATATTTCAATCCATTGAAATCAGAAAGG
    TACTATCGTAATTTAGATGAACAAGTACTCGCATTAATTACTGGTGAAATTGGATCAATG
    CCAGATTTGAAAAAGCCCGAAGATAAGCCGGATTCAAAACAACGCTCATTTGAACCGCAT
    GAAAAAGAAGATTTTACAGTAGTTAAAAAACAAGAAGATAATAAGAAAAGTGCGTCAACT
    GCATATAGTAAAAGTTGGCTAGCAATTGTATGTTCTATGATGGTGGTATTTTCAATCATG
    CTATTCTTATTTGTAAAGCGAAATAAAAAGAAAAATAAAAACGAATCACAGCGACGATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_001985
  • symbol: JSNZ_001985
  • description: SdrH family protein
  • length: 419
  • theoretical pI: 8.72247
  • theoretical MW: 46632.8
  • GRAVY: -1.4031

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    no clan defined Orf78; Orf78 (ac78) (PF06024; HMM-score: 14.6)
    COX2-transmemb; Cytochrome C oxidase subunit II, transmembrane (PF09125; HMM-score: 11.7)
    and 3 more
    NEDD4_Bsd2; NEDD4/Bsd2 (PF10176; HMM-score: 9.9)
    Peptidase_AD (CL0130) Presenilin; Presenilin (PF01080; HMM-score: 8.3)
    ABC-2 (CL0181) ABC2_membrane_3; ABC-2 family transporter protein (PF12698; HMM-score: 6.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 3.33
    • Cellwall Score: 3.33
    • Extracellular Score: 3.33
    • Internal Helix: 1
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0002
    • Cytoplasmic Membrane Score: 0.2247
    • Cell wall & surface Score: 0.5619
    • Extracellular Score: 0.2132
  • LocateP:
  • SignalP: Signal peptide SP(Sec/SPI) length 32 aa
    • SP(Sec/SPI): 0.990235
    • TAT(Tat/SPI): 0.006169
    • LIPO(Sec/SPII): 0.002709
    • Cleavage Site: CS pos: 32-33. VEA-KD. Pr: 0.9595
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSYHWFKKMLLSTSILILSSSSLGLATHTVEAKDNLNGEKPTTNLNHNITSPSVNSEMNNNETGTPHESNQTGNEGTGSNSRDANPDSNNVKPDSNNQNPSTDSKPDPNNQNPSPNPKPDPDNPKPKPDPKPDPDKPKPNPDPKPDPDNPKPNPDPKPDPDNPKPKPDPKPDPDKPKPNPNPKPDPNKSNPNPSPDPNQPGDSNHSGGSKNGGTWNPNASDGSNQGQWQPNGNQGNSQNPTGNDFVSQRFLALANGAYKYNPYILNQINKLGKDYGEVTDEDIYNIIRKQNFSGNAYLNGLQQQSNYFRFQYFNPLKSERYYRNLDEQVLALITGEIGSMPDLKKPEDKPDSKQRSFEPHEKEDFTVVKKQEDNKKSASTAYSKSWLAIVCSMMVVFSIMLFLFVKRNKKKNKNESQRR

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: GraR (repression) regulon
    GraR(response regulator)important in cationic antimicrobial peptide (CAMP) resistance;  [1]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Mélanie Falord, Ulrike Mäder, Aurélia Hiron, Michel Débarbouillé, Tarek Msadek
    Investigation of the Staphylococcus aureus GraSR regulon reveals novel links to virulence, stress response and cell wall signal transduction pathways.
    PLoS One: 2011, 6(7);e21323
    [PubMed:21765893] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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