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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_000368
  • pan locus tag?: SAUPAN002129000
  • symbol: JSNZ_000368
  • pan gene symbol?: ssl11
  • synonym:
  • product: superantigen-like protein SSL11

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_000368
  • symbol: JSNZ_000368
  • product: superantigen-like protein SSL11
  • replicon: chromosome
  • strand: +
  • coordinates: 401612..402304
  • length: 693
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAAATTAAAAAATATTGCTAAAGCAAGTTTAGCACTAGGGATTTTAACAACAGGGATG
    ATTACAACTACTGCTCAGCCAGTAAAAGCAGACGAAACTAGTAGCAGATTAGCAGTTACT
    TCAAAAGATACACAAGAATTAAAAAAATACTACAGTGGAACAGGATATAATTTTCAAAAT
    GTAAGTGGCTATAGTGAAAACGACAAAATGAATGTATTTTTCGGACCACAACTTAATGTA
    ATATCATTGCTTGGTTCAGATAAAGAGAGATTTAAAGATGGTGATTATAATGGACTAGAT
    GTATTTGTCGTACGTGAAGGATCTGGTAGACAAGCAGATAATAATTCAATAGGTGGAATT
    ACAAAGACAAATAAAAATGGTTATACAGATTTCGTAAAAAATGTTGGTTTAGAAATAACA
    AAACCAACAGGACATAATACAGCAACAAGACAAGCAGAAACTTATAGTATTAATAAAGAA
    GAAATTTCATTAAAAGAATTAGATTTCAAATTAAGAAAGCACTTAATTGACAATAACGGT
    TTATATAACACTGAGCCTAAAGATAGCAAAATAAAAGTGACTATGCAAAATGGTGATTTT
    TATACTTTTGAATTGAATAAAAAGTTACAAACTCATCGTATGGGTGATGTGATTGATGGT
    AGAAATATAGAGAAAATTGAAGTGAATTTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    693

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_000368
  • symbol: JSNZ_000368
  • description: superantigen-like protein SSL11
  • length: 230
  • theoretical pI: 9.3434
  • theoretical MW: 25693.7
  • GRAVY: -0.667391

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    Ubiquitin (CL0072) Stap_Strp_tox_C; Staphylococcal/Streptococcal toxin, beta-grasp domain (PF02876; HMM-score: 102.1)
    and 2 more
    OB_enterotoxin (CL0658) SSL_OB; Staphylococcal superantigen-like OB-fold domain (PF09199; HMM-score: 77)
    no clan defined MAP; MAP domain (PF03642; HMM-score: 13.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 10
    • Internal Helices: 0
  • DeepLocPro: Extracellular
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.0005
    • Cell wall & surface Score: 0.0055
    • Extracellular Score: 0.9939
  • LocateP:
  • SignalP: Signal peptide SP(Sec/SPI) length 30 aa
    • SP(Sec/SPI): 0.994092
    • TAT(Tat/SPI): 0.003329
    • LIPO(Sec/SPII): 0.001985
    • Cleavage Site: CS pos: 30-31. VKA-DE. Pr: 0.9617
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLKNIAKASLALGILTTGMITTTAQPVKADETSSRLAVTSKDTQELKKYYSGTGYNFQNVSGYSENDKMNVFFGPQLNVISLLGSDKERFKDGDYNGLDVFVVREGSGRQADNNSIGGITKTNKNGYTDFVKNVGLEITKPTGHNTATRQAETYSINKEEISLKELDFKLRKHLIDNNGLYNTEPKDSKIKVTMQNGDFYTFELNKKLQTHRMGDVIDGRNIEKIEVNL

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: SaeR (activation) regulon
    SaeR(TF)important in Virulence;  regulation predicted or transferred from N315 and NCTC 8325  [2]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

Stefan Monecke, Peter Slickers, Ralf Ehricht
Assignment of Staphylococcus aureus isolates to clonal complexes based on microarray analysis and pattern recognition.
FEMS Immunol Med Microbiol: 2008, 53(2);237-51
[PubMed:18507678] [WorldCat.org] [DOI] (P p)

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