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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_000361
  • pan locus tag?: SAUPAN002113000
  • symbol: JSNZ_000361
  • pan gene symbol?: ssl7
  • synonym:
  • product: superantigen-like protein SSL7

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_000361
  • symbol: JSNZ_000361
  • product: superantigen-like protein SSL7
  • replicon: chromosome
  • strand: +
  • coordinates: 394343..395038
  • length: 696
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAAATTAAAAACGTTAGCTAAAGCAACATTGGCATTAGGCTTATTAACTACTGGTGTG
    ATTACATCAGAAGGCCAAGCAGTTCAAGCAAAAGAAAAGCAAGAGAGAGTACAACATTTA
    TATGATATTAAAGACTTACATCGATACTACTCATCAGAAAGTTTTGAATTCAGTAATATT
    AGTGGTAAGGTTGAAAACTATAATGGTTCTAACGTTGTACGCTTTAACCAAGATGGTCAA
    AATCACCAATTATTCTTATTAGGAGAAGATAAAGATAAATATAAAAAAGGCCTTGAAGGC
    CAGAATGTCTTTGTGGTAAAAGAATTAATTGATCCAAACGGTAGACTATCTACTGTTGGT
    GGTGTAACGAAGAAAAATAACCAATCTTCTGAAACTAATACACCTTTAGTAGTTAATAAA
    GTGTATGGAGGAGATTTACATGCATCAATTGACTCATTTTCAATTAATAAAGAAGAAGTT
    TCACTTAAAGAACTTGATTTCAAAATTAGAAAGCAATTAGTTGAAAAATACGGTTTATAT
    CAAGGTACGTCTAAATACGGTAAAATCACTATCATCTTGAACGGCGGGAAAAAGGAAGTA
    ATTGATTTAGGTGATAAATTGCAATTCGAGCGCATGGGTGATGTGTTGAATAGTAAGGAT
    ATTAATAAGATTGAAGTGACTTTGAAACAAATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    696

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_000361
  • symbol: JSNZ_000361
  • description: superantigen-like protein SSL7
  • length: 231
  • theoretical pI: 9.49485
  • theoretical MW: 25905.3
  • GRAVY: -0.541991

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED: data available for N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    OB_enterotoxin (CL0658) SSL_OB; Staphylococcal superantigen-like OB-fold domain (PF09199; HMM-score: 101.8)
    Ubiquitin (CL0072) Stap_Strp_tox_C; Staphylococcal/Streptococcal toxin, beta-grasp domain (PF02876; HMM-score: 98)
    and 1 more
    no clan defined MAP; MAP domain (PF03642; HMM-score: 15.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 10
    • Internal Helices: 0
  • DeepLocPro: Extracellular
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.0009
    • Cell wall & surface Score: 0.0447
    • Extracellular Score: 0.9544
  • LocateP:
  • SignalP: Signal peptide SP(Sec/SPI) length 30 aa
    • SP(Sec/SPI): 0.98519
    • TAT(Tat/SPI): 0.002363
    • LIPO(Sec/SPII): 0.00867
    • Cleavage Site: CS pos: 30-31. VQA-KE. Pr: 0.8054
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLKTLAKATLALGLLTTGVITSEGQAVQAKEKQERVQHLYDIKDLHRYYSSESFEFSNISGKVENYNGSNVVRFNQDGQNHQLFLLGEDKDKYKKGLEGQNVFVVKELIDPNGRLSTVGGVTKKNNQSSETNTPLVVNKVYGGDLHASIDSFSINKEEVSLKELDFKIRKQLVEKYGLYQGTSKYGKITIILNGGKKEVIDLGDKLQFERMGDVLNSKDINKIEVTLKQI

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: SaeR (activation) regulon
    SaeR(TF)important in Virulence;  regulation predicted or transferred from N315 and NCTC 8325  [1]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

Stefan Monecke, Peter Slickers, Ralf Ehricht
Assignment of Staphylococcus aureus isolates to clonal complexes based on microarray analysis and pattern recognition.
FEMS Immunol Med Microbiol: 2008, 53(2);237-51
[PubMed:18507678] [WorldCat.org] [DOI] (P p)

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