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FunGene: 08-OCT-2024
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus JSNZ
- locus tag: JSNZ_000309
- pan locus tag?: SAUPAN001899000
- symbol: JSNZ_000309
- pan gene symbol?: mdh
- synonym:
- product: cyclase family protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: JSNZ_000309
- symbol: JSNZ_000309
- product: cyclase family protein
- replicon: chromosome
- strand: -
- coordinates: 345216..345968
- length: 753
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID:
- RefSeq:
- BioCyc:
- MicrobesOnline:
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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721ATGACACAATATCCTTTATGGCAACAATTAAATACTTTAAAACAAGCAACTTGGGTTGAT
TTAACGCATACATTTGATCCGGAAATACCACGTTTTAGTGAGTTTGAAAAAGGCGAAGTT
TCAACTTTATTCACGGTTAAAGATCATGGTTTCTATGTGCAACGTTGGAATATTGTAACG
CAATATGGTACTCACATTGATGCACCAATTCACTTTGTCGAGAATAAACGTTATTTAGAA
GACATTGATTTAAAAGAATTGGTATTGCCGTTAATTGTATTAGACTTTTCAACAGAAGTA
GCGAACAACAATGATTTCATTGTAACACGTGCGCATATAGAAGCATGGGAAAAAGAGCAT
GGTACTATTGAACCTGGCACTTTTGTTGCACTTCGTACCGATTGGTCAAAACGTTGGCCT
AATATTGAAAAGTTTGAAAACAAAGATGCGAACGGACAACAACATGCACCGGGTTGGGGA
TTAGATGCTTTGAAGTACTTAATTGAAGAACGTCGTGTTGAAGCTGTTGGTCATGAAACA
TTCGATACCGATGCATCTGTGGACGTTGTAAAAAATGGTGATTTAGTTGGCGAACGTTAT
ATTCTTGGTCAGGATAAATACCAAGTCGAGTTATTAACTAATTTAGATCAATTACCAACT
CGTGGCGCCATCATTTACGCTATCAGCCCTAAACCAAAAGATGCACCTGGGTTCCCTGTT
AGAGCATTTGCAATTAAACCATCAAATGACTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: JSNZ_000309
- symbol: JSNZ_000309
- description: cyclase family protein
- length: 250
- theoretical pI: 4.8323
- theoretical MW: 28752.1
- GRAVY: -0.4592
⊟Function[edit | edit source]
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9961
- Cytoplasmic Membrane Score: 0.0002
- Cell wall & surface Score: 0
- Extracellular Score: 0.0036
- LocateP:
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.004083
- TAT(Tat/SPI): 0.000231
- LIPO(Sec/SPII): 0.00074
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq:
- UniProt:
⊟Protein sequence[edit | edit source]
- MTQYPLWQQLNTLKQATWVDLTHTFDPEIPRFSEFEKGEVSTLFTVKDHGFYVQRWNIVTQYGTHIDAPIHFVENKRYLEDIDLKELVLPLIVLDFSTEVANNNDFIVTRAHIEAWEKEHGTIEPGTFVALRTDWSKRWPNIEKFENKDANGQQHAPGWGLDALKYLIEERRVEAVGHETFDTDASVDVVKNGDLVGERYILGQDKYQVELLTNLDQLPTRGAIIYAISPKPKDAPGFPVRAFAIKPSND
⊟Experimental data[edit | edit source]
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- data available for N315
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Dmitry A Rodionov, Alexey G Vitreschak, Andrey A Mironov, Mikhail S Gelfand
Comparative genomics of the methionine metabolism in Gram-positive bacteria: a variety of regulatory systems.
Nucleic Acids Res: 2004, 32(11);3340-53
[PubMed:15215334] [WorldCat.org] [DOI] (I e)Sonja M K Schoenfelder, Gabriella Marincola, Tobias Geiger, Christiane Goerke, Christiane Wolz, Wilma Ziebuhr
Methionine biosynthesis in Staphylococcus aureus is tightly controlled by a hierarchical network involving an initiator tRNA-specific T-box riboswitch.
PLoS Pathog: 2013, 9(9);e1003606
[PubMed:24068926] [WorldCat.org] [DOI] (I p)