PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 22-FEB-2026

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: EGJ38_RS10455 [old locus tag: EGJ38_002094 ]
• pan locus tag^?: SAUPAN005429000
• symbol: EGJ38_RS10455
• pan gene symbol^?: hmrA
• synonym:
• product: M20 family metallopeptidase

⊟Additional information (user-provided)

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: EGJ38_RS10455 [old locus tag: EGJ38_002094 ]
• symbol: EGJ38_RS10455
• product: M20 family metallopeptidase
• replicon: chromosome
• strand: -
• coordinates: 2106361..2107548
• length: 1188
• essential: unknown other strains

⊟Accession numbers

• Location: NZ_CM129921 (2106361..2107548) NCBI
• BioCyc:
• MicrobesOnline:

⊟Phenotype

⊟Additional information (user-provided)

⊟DNA sequence

• 1
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  ATGAGTGAAAAACAACAAATTCTCGATTATATAGAAACAAATAAATATAGTTATATCGAA
  ATCAGTCATAGAATTCATGAACGTCCTGAACTTGGTAATGAAGAAATATTTGCGTCTCGA
  ACTTTAATAGATCGTTTGAAAGAGCATGATTTTGAAATTGAAACCGAGATTGCTGGGCAT
  GCAACTGGGTTTATAGCGACATATGATTCAGGTCTTGACGGGCCAGCTATAGGTTTTTTA
  GCAGAATACGATGCTTTGCCAGGATTGGGTCATGCTTGTGGTCATAATATCATTGGAACT
  GCAAGTGTGCTTGGTGCAATTGGTTTGAAGCAAGTGATTGACCAAATTGGTGGTAAAGTA
  GTCGTTCTTGGATGTCCAGCTGAAGAAGGTGGGGAAAATGGTAGCGCTAAAGCTTCTTAT
  GTCAAGGCTGGTGTGATTGATCAAATAGACATTGCCTTAATGATTCATCCGGGAAATGAA
  ACTTATAAAACGATTGATACTTTGGCAGTGGATGTTTTAGATGTTAAATTTTACGGAAAA
  AGTGCTCATGCCTCTGAAAATGCAGATGAAGCGTTAAATGCATTAGACGCTATGATTAGT
  TATTTTAATGGTGTAGCACAACTACGACAACATATTAAAAAAGATCAACGTGTGCATGGT
  GTGATTTTAGATGGCGGGAAAGCAGCTAATATTATTCCAGACTATACACATGCTCGTTTT
  TATACTAGAGCAATGACGCGTAAAGAATTGGATATATTAACAGAAAAAGTAAATCAAATC
  GCACGTGGAGCTGCGATACAGACTGGTTGTGATTATGAATTTGGTCCAATTCAAAACGGT
  GTGAATGAATTCATTAAAACGCCGAAATTAGATGATTTATTTGCTAAATATGCTGAAGAA
  GTTGGTGAAGCAGTTATTGATGATGATGATTTTGGTTATGGCTCTACGGATACAGGGAAC
  GTAAGTCATGTTGTGCCAACAATACATCCTCATATTAAAATAGGATCACGTAATTTAGTA
  GGACATACGCATAGATTTAGAGAAGCGGCTGCGAGTGTACATGGTGATGAAGCATTAATT
  AAAGGTGCTAAAATAATGGCGTTGATGGGGTTAGAGTTAATTACAAATCAAGACGTTTAT
  CAAGACATTATTGAAGAGCATGCGCATTTGAAAGGGAATGGGAAGTAA
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⊟Protein

⊟General

• locus tag: EGJ38_RS10455 [old locus tag: EGJ38_002094 ]
• symbol: EGJ38_RS10455
• description: M20 family metallopeptidase
• length: 395
• theoretical pI: 5.07782
• theoretical MW: 43014.1
• GRAVY: -0.220253

⊟Function

• TIGRFAM:
  Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides amidohydrolase (TIGR01891; HMM-score: 203.7)
  and 4 more
  Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides peptidase, ArgE/DapE family (TIGR01910; EC 3.4.-.-; HMM-score: 44.7)
  Metabolism Amino acid biosynthesis Glutamate family acetylornithine deacetylase (ArgE) (TIGR01892; EC 3.5.1.16; HMM-score: 18.6)
  Metabolism Amino acid biosynthesis Aspartate family succinyl-diaminopimelate desuccinylase (TIGR01900; EC 3.5.1.18; HMM-score: 14.7)
  Metabolism Amino acid biosynthesis Aspartate family succinyl-diaminopimelate desuccinylase (TIGR01246; EC 3.5.1.18; HMM-score: 13.2)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  ZnExoPePases (CL0865) Peptidase_M20; Peptidase family M20/M25/M40 (PF01546; HMM-score: 35.1)
  no clan defined M20_dimer; Peptidase dimerisation domain (PF07687; HMM-score: 32.3)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9966
  • Cytoplasmic Membrane Score: 0.0014
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0019
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.002298
  • TAT(Tat/SPI): 0.000106
  • LIPO(Sec/SPII): 0.0002
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_123163162 NCBI
• UniProt:

⊟Additional information (user-provided)

⊟Protein sequence

• MSEKQQILDYIETNKYSYIEISHRIHERPELGNEEIFASRTLIDRLKEHDFEIETEIAGHATGFIATYDSGLDGPAIGFLAEYDALPGLGHACGHNIIGTASVLGAIGLKQVIDQIGGKVVVLGCPAEEGGENGSAKASYVKAGVIDQIDIALMIHPGNETYKTIDTLAVDVLDVKFYGKSAHASENADEALNALDAMISYFNGVAQLRQHIKKDQRVHGVILDGGKAANIIPDYTHARFYTRAMTRKELDILTEKVNQIARGAAIQTGCDYEFGPIQNGVNEFIKTPKLDDLFAKYAEEVGEAVIDDDDFGYGSTDTGNVSHVVPTIHPHIKIGSRNLVGHTHRFREAAASVHGDEALIKGAKIMALMGLELITNQDVYQDIIEEHAHLKGNGK

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell: data available for COL
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator: CodY see EGJ38_002094

⊟Additional information (user-provided)

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: data available for COL

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Additional information (user-provided)

⊟Other information (user-provided)

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications