PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 22-FEB-2026

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: EGJ38_RS07935 [old locus tag: EGJ38_001589 ]
• pan locus tag^?: SAUPAN004185000
• symbol: mtnN
• pan gene symbol^?: mtnN
• synonym:
• product: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

⊟Additional information (user-provided)

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: EGJ38_RS07935 [old locus tag: EGJ38_001589 ]
• symbol: mtnN
• product: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
• replicon: chromosome
• strand: -
• coordinates: 1623715..1624401
• length: 687
• essential: unknown other strains

⊟Accession numbers

• Location: NZ_CM129921 (1623715..1624401) NCBI
• BioCyc:
• MicrobesOnline:

⊟Phenotype

⊟Additional information (user-provided)

⊟DNA sequence

• 1
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  541
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  661
  
  ATGATTGGTATAATTGGTGCCATGGAAGAAGAAGTAACAATATTAAAAAATAAATTAACA
  CAATTAAGCGAAATTTCAGTTGCACATGTTAAATTTTATACTGGCATTTTAAAAGATAGA
  GAAGTAGTGATTACCCAAAGCGGCATTGGAAAAGTTAATGCTGCAATTTCTACGACATTA
  TTAATTAATAAGTTTAAACCGGACGTCATTATTAATACAGGTTCTGCTGGAGCTTTAGAT
  GAAAGTTTAAATGTAGGTGACGTTCTTATAAGTGATGATGTAAAATATCATGATGCGGAT
  GCAACAGCATTTGGTTATGAATATGGACAAATACCACAGATGCCGGTAGCATTTCAATCA
  AGTAAACCTTTAATAGAAAAAGTATCTCAAGTTGTACAACAACAACAATTAACAGCTAAA
  GTAGGCTTAATTGTAAGTGGTGATAGCTTTATCGGTAGTGTTGAACAACGCCAAAAAATT
  AAAAAAGCATTTCCAAATGCGATGGCGGTTGAAATGGAAGCAACTGCAATTGCACAAACA
  TGTTATCAATTTAATGTACCATTTGTTGTAGTTCGTGCAGTTTCAGACTTAGCAAATGGA
  GAAGCGGAAATGAGCTTCGAAGCATTTTTAGAAAAAGCAGCTGTATCATCAAGTCAAACT
  GTTGAAGCATTAGTGTCTCAATTATAA
  60
  120
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  540
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  660
  687
  

⊟Protein

⊟General

• locus tag: EGJ38_RS07935 [old locus tag: EGJ38_001589 ]
• symbol: MtnN
• description: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
• length: 228
• theoretical pI: 4.55905
• theoretical MW: 24534
• GRAVY: 0.183772

⊟Function

• reaction:
  EC 3.2.2.9?  ExPASy
  Adenosylhomocysteine nucleosidase S-adenosyl-L-homocysteine + H₂O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
  EC 3.2.2.16?  ExPASy
  Methylthioadenosine nucleosidase S-methyl-5'-thioadenosine + H₂O = S-methyl-5-thio-D-ribose + adenine
• TIGRFAM:
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides MTA/SAH nucleosidase (TIGR01704; EC 3.2.2.16,3.2.2.9; HMM-score: 297.3)
  Metabolism Central intermediary metabolism Other MTA/SAH nucleosidase (TIGR01704; EC 3.2.2.16,3.2.2.9; HMM-score: 297.3)
  and 10 more
  futalosine hydrolase (TIGR03664; EC 3.2.2.26; HMM-score: 90.6)
  hopanoid-associated phosphorylase (TIGR03468; HMM-score: 78.2)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides purine nucleoside phosphorylase (TIGR00107; EC 2.4.2.1; HMM-score: 61.6)
  putative 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (TIGR01705; HMM-score: 52.4)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine phosphorylase (TIGR01718; EC 2.4.2.3; HMM-score: 33.8)
  AMP nucleosidase (TIGR01717; EC 3.2.2.4; HMM-score: 31.6)
  putative AMP nucleosidase (TIGR01721; HMM-score: 25.5)
  inosine/guanosine/xanthosine phosphorylase family (TIGR01697; EC 2.4.2.1; HMM-score: 18)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides methylthioadenosine phosphorylase (TIGR01694; EC 2.4.2.28; HMM-score: 15.1)
  Metabolism Central intermediary metabolism Other methylthioadenosine phosphorylase (TIGR01694; EC 2.4.2.28; HMM-score: 15.1)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  PUP (CL0408) PNP_UDP_1; Phosphorylase superfamily (PF01048; HMM-score: 195.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9971
  • Cytoplasmic Membrane Score: 0.0006
  • Cell wall & surface Score: 0.0003
  • Extracellular Score: 0.0021
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.002526
  • TAT(Tat/SPI): 0.000256
  • LIPO(Sec/SPII): 0.000288
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000579275 NCBI
• UniProt:

⊟Additional information (user-provided)

⊟Protein sequence

• MIGIIGAMEEEVTILKNKLTQLSEISVAHVKFYTGILKDREVVITQSGIGKVNAAISTTLLINKFKPDVIINTGSAGALDESLNVGDVLISDDVKYHDADATAFGYEYGQIPQMPVAFQSSKPLIEKVSQVVQQQQLTAKVGLIVSGDSFIGSVEQRQKIKKAFPNAMAVEMEATAIAQTCYQFNVPFVVVRAVSDLANGEAEMSFEAFLEKAAVSSSQTVEALVSQL

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell: data available for COL
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Additional information (user-provided)

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: data available for COL

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Additional information (user-provided)

⊟Other information (user-provided)

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications