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NCBI: 01-DEC-2025

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: EGJ38_001691 [new locus tag: EGJ38_RS08445 ]
  • pan locus tag?: SAUPAN004358000
  • symbol: EGJ38_001691
  • pan gene symbol?: —
  • synonym:
  • alternate name: JSNZ_001691
  • product: metal-dependent hydrolase

⊟Additional information (user-provided)[edit | edit source]

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EGJ38_001691 [new locus tag: EGJ38_RS08445 ]
  • symbol: EGJ38_001691
  • product: metal-dependent hydrolase
  • replicon: chromosome
  • strand: -
  • coordinates: 1733858..1734547
  • length: 690
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq: MGT2423647 NCBI
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAAGTTATCATTTCATGGTCAATCAACGATTTATTTAGAAGGGAACAACAAAAAGGTT
    ATCGTAGATCCGTTTATTTCAAATAACCCTAAGTGTGATTTGAATATTGAAACAGTGCAG
    GTAGACTATATCGTTTTAACGCACGGTCATTTTGATCATTTTGGTGATGTTGTGGAACTA
    GCAAAGAAAACAGGAGCAACAGTAATTGGAAGTGCAGAAATGGCTGACTATCTTTCTTCA
    TATCACGGTGTTGAAAATGTTCATGGTATGAATATTGGTGGTAAAGCAAACTTTGATTTC
    GGAAGCGTTAAATTTGTTCAAGCATTTCATAGTTCAAGTTTTACACATGAAAATGGTATT
    CCAGTTTATTTAGGTATGCCAATGGGTATCGTGTTTGAAGTTGAAGGAAAAACAATTTAT
    CATACTGGTGATACAGGTCTGTTTAGTGATATGTCACTTATTGCGAAACGTCATCCAGTT
    GATGTATGTTTTGTACCAATTGGAGATAATTTTACGATGGGTATTGATGATGCAAGTTAT
    GCTATTAATGAATTTATTAAACCAAAAATTTCTGTACCGATTCATTATGATACATTCCCA
    TTAATCGAACAAGATCCACAACAATTTAAAGATGCTGTTAATGTAGGGGACGTGCAAATT
    TTAAAACCAGGTGAATCTGTTCAGTTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    690


⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EGJ38_001691 [new locus tag: EGJ38_RS08445 ]
  • symbol: EGJ38_001691
  • description: metal-dependent hydrolase
  • length: 229
  • theoretical pI: 5.03066
  • theoretical MW: 25250.4
  • GRAVY: -0.0462882

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Detoxification hydroxyacylglutathione hydrolase (TIGR03413; EC 3.1.2.6; HMM-score: 30.7)
    and 4 more
    arCOG00543 universal archaeal KH-domain/beta-lactamase-domain protein (TIGR03675; HMM-score: 14.6)
    Genetic information processing Transcription Degradation of RNA beta-CASP ribonuclease, RNase J family (TIGR00649; EC 3.1.-.-; HMM-score: 13.9)
    Unknown function Enzymes of unknown specificity quinoprotein relay system zinc metallohydrolase 2 (TIGR04559; EC 3.-.-.-; HMM-score: 13.6)
    Genetic information processing Transcription RNA processing ribonuclease Z (TIGR02651; EC 3.1.26.11; HMM-score: 11.2)
  • TheSEED: data available for N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    Metallo-HOrase (CL0381) Lactamase_B_2; Beta-lactamase superfamily domain (PF12706; HMM-score: 85.5)
    Lactamase_B_3; Beta-lactamase superfamily domain (PF13483; HMM-score: 73.9)
    and 1 more
    Lactamase_B; Metallo-beta-lactamase superfamily (PF00753; HMM-score: 62.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9638
    • Cytoplasmic Membrane Score: 0.0063
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0298
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010219
    • TAT(Tat/SPI): 0.00011
    • LIPO(Sec/SPII): 0.000935
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: MGT2423647 NCBI
  • UniProt:

⊟Additional information (user-provided)[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: SigB (activation) regulon
    SigB(sigma factor)controlling a large regulon involved in stress/starvation response and adaptation;  [1] [2] [3]   other strains

⊟Additional information (user-provided)[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟Other information (user-provided)[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Markus Bischoff, Paul Dunman, Jan Kormanec, Daphne Macapagal, Ellen Murphy, William Mounts, Brigitte Berger-Bächi, Steven Projan
    Microarray-based analysis of the Staphylococcus aureus sigmaB regulon.
    J Bacteriol: 2004, 186(13);4085-99
    [PubMed:15205410] [WorldCat.org] [DOI] (P p)
  2. ↑ Jan Pané-Farré, Beate Jonas, Konrad Förstner, Susanne Engelmann, Michael Hecker
    The sigmaB regulon in Staphylococcus aureus and its regulation.
    Int J Med Microbiol: 2006, 296(4-5);237-58
    [PubMed:16644280] [WorldCat.org] [DOI] (P p)
  3. ↑ Bettina Schulthess, Dominik A Bloes, Patrice François, Myriam Girard, Jacques Schrenzel, Markus Bischoff, Brigitte Berger-Bächi
    The σB-dependent yabJ-spoVG operon is involved in the regulation of extracellular nuclease, lipase, and protease expression in Staphylococcus aureus.
    J Bacteriol: 2011, 193(18);4954-62
    [PubMed:21725011] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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