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NCBI: 10-JUN-2013

Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1000 [new locus tag: SACOL_RS05110 ]
  • pan locus tag?: SAUPAN003156000
  • symbol: SACOL1000
  • pan gene symbol?: opp4C
  • synonym:
  • product: oligopeptide ABC transporter permease

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SACOL1000 [new locus tag: SACOL_RS05110 ]
  • symbol: SACOL1000
  • product: oligopeptide ABC transporter permease
  • replicon: chromosome
  • strand: +
  • coordinates: 1008235..1009116
  • length: 882
  • essential: unknown other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGCAAAATAAGTCAAAATCGCCTTTTAAAATTGCATTTTCTAAATTTATTCATAATAAA
    ATTGCAATGTTATCGGTTATTTTTTTATTAATCATAACTATTGTATCAATTATAGCGCCA
    TTAATAGCTCCTTTTCCAGTGAACCAACAAGATTTATTAAATATAAAAGGTGAAATGACA
    GCACAAAACATTCTTGGTACAGACTCTGGTGGTAGGGATAACTTTAGTCGTTTGTTATAT
    GCAGGTCGTATTTCATTATCCATTGGAATTACATCTACAATAGGAATGCTTTTGATTGGA
    ATTACAGTTGGAGTGATTTCTGGTTATTTTGGAGGTATTGTTGATACATTATTAATGAGA
    ATAACCGAATTTGTTATGTTATTTCCATTTTTAATATTTGCAATTGTATTAAATGCTGCA
    CTTGGAGATAAAATTAAAAATCCTTATGGATCTGCCATAATTCTTGTTCTAGTTATTATC
    GTATTAAGTTGGGGAGGTATTGCAAGACTTGTTCGTGGTAAAGTACTTCAAGAAAAAGAA
    AATGAATACTTTTTGGCAGCAAAATCAATTGGTACACCCACATATAAAATTATTTTGAAA
    CATCTTTTGCCGAATATATTAAGTGTAGTTATCGTACAAGCAACATTGTTATTTGCCGGT
    ATGATTGTAGTGGAATCAGGATTGAGCTTTTTAGGATTCGGAATTAGTAAAGCAATACCA
    TCTTGGGGTAATATGTTGAGTGATGCTCAAGAAGGGGATGTTATAAGTGGTAAACCGTGG
    ATATGGATGCCACCTGCTATAATGATTACATTAACTATATTAAGTATAAACTTTGTAGGG
    GAAGGGATTAAAGATGCTTTTAATCCTAGAGGTAGACGTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    882

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SACOL1000 [new locus tag: SACOL_RS05110 ]
  • symbol: SACOL1000
  • description: oligopeptide ABC transporter permease
  • length: 293
  • theoretical pI: 10.4056
  • theoretical MW: 31819.9
  • GRAVY: 0.722526

Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel ABC transporter, permease subunit NikC (TIGR02790; EC 3.6.3.24; HMM-score: 202.1)
    and 3 more
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel ABC transporter, permease subunit NikB (TIGR02789; EC 3.6.3.24; HMM-score: 22.3)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, permease protein CysT (TIGR02139; HMM-score: 19)
    Metabolism Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, permease protein (TIGR03262; HMM-score: 14.5)
  • TheSEED  :
    • Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1)
    Membrane Transport ABC transporters ABC transporter oligopeptide (TC 3.A.1.5.1)  Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1)
  • PFAM:
    BPD_transp_1 (CL0404) BPD_transp_1; Binding-protein-dependent transport system inner membrane component (PF00528; HMM-score: 107.7)
    and 1 more
    no clan defined OppC_N; N-terminal TM domain of oligopeptide transport permease C (PF12911; HMM-score: 41.8)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 6
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: 0
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.184731
    • TAT(Tat/SPI): 0.00093
    • LIPO(Sec/SPII): 0.004192
  • predicted transmembrane helices (TMHMM): 6

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MQNKSKSPFKIAFSKFIHNKIAMLSVIFLLIITIVSIIAPLIAPFPVNQQDLLNIKGEMTAQNILGTDSGGRDNFSRLLYAGRISLSIGITSTIGMLLIGITVGVISGYFGGIVDTLLMRITEFVMLFPFLIFAIVLNAALGDKIKNPYGSAIILVLVIIVLSWGGIARLVRGKVLQEKENEYFLAAKSIGTPTYKIILKHLLPNILSVVIVQATLLFAGMIVVESGLSFLGFGISKAIPSWGNMLSDAQEGDVISGKPWIWMPPAIMITLTILSINFVGEGIKDAFNPRGRR

Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Regulation[edit | edit source]

  • regulator: CodY (repression) regulon
    CodY(TF)important in Amino acid metabolism; RegPrecise    transcription unit transferred from N315 data RegPrecise 

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]

Suzanne E Dale, Amanda Doherty-Kirby, Gilles Lajoie, David E Heinrichs
Role of siderophore biosynthesis in virulence of Staphylococcus aureus: identification and characterization of genes involved in production of a siderophore.
Infect Immun: 2004, 72(1);29-37
[PubMed:14688077] [WorldCat.org] [DOI] (P p)