⊟Summary[edit | edit source]

PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus COL
locus tag: SACOL_RS06650 [old locus tag: SACOL1303 ]
pan locus tag^?: SAUPAN003586000
symbol: SACOL_RS06650
pan gene symbol^?: cinA
• synonym:
• product: competence protein CinA

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SACOL_RS06650 [old locus tag: SACOL1303 ]
• symbol: SACOL_RS06650
• product: competence protein CinA
• replicon: chromosome
• strand: +
• coordinates: 1318681..1319832
• length: 1152
• essential: unknown other strains

⊟Accession numbers

• Location: NC_002951 (1318681..1319832) NCBI
• BioCyc: SACOL_RS06650 BioCyc
• MicrobesOnline: see SACOL1303

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

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  ATGTCAATTGCCATTATTGCTGTAGGCTCAGAACTATTGCTAGGTCAAATCGCTAATACC
  AACGGACAATTTCTATCTAAAGTATTTAATGAAATTGGACAAAATGTATTAGAACATAAA
  GTTATTGGAGATAATAAAAAACGTTTAGAATCAAGTGTACGTCATGCGCTAGAAAAATAT
  GATACTGTTATTTTAACAGGTGGCTTAGGTCCTACGAAAGATGACTTAACGAAGCATACA
  GTGGCCCAGATTGTTGGTAAAGATTTAGTTATTGATGAGCCTTCTTTAAAATATATTGAA
  AGCTATTTTGAGGAACAAGGACAAGAAATGACACCTAATAATAAACAACAGGCTTTAGTA
  ATTGAAGGTTCAACTGTATTAACAAATCATCATGGCATGGCTCCAGGAATGATGGTGAAT
  TTTGAAAACAAACAAATTATTTTATTACCAGGTCCACCGAAAGAAATGCAACCAATGGTG
  AAAAATGAATTGTTGTCACATTTTATAAACCATAATCGAATTATACATTCTGAACTATTA
  AGATTTGCGGGAATAGGTGAATCTAAAGTAGAAACAATATTAATAGATCTTATCGATAAA
  CAGACTAATCCTACGATTGCGCCTTTGGCGGGAAGTCATGAAGTATATATTAGATTGACT
  GCAAATGCCGACTCAAAAGAACAAGCACAATCATTGATTCAACCTGTTAAACAAGAAATT
  CTTGATCGTATTGGAGAATATTATTATGGTTCAGATGACACATTAATTGAGCAAGCTGTA
  ATAAAGAAAATTCATGAACCTTTTGTAATATATGATGGTATTACTAATGGTGCTTTATAT
  CATCGATTGAAAGAAGTGGATTTAAACGATGTTCTAAAGGGTATGATTAATCACAATGAA
  AACTTTGTTGATATTAATAAACCTATTGAGCAGCAATTAAAAGATGCAGTGCAATTTGTT
  AATAAATTGTTTAATGTGTCATCAGCAATTATTCTATTAGAGTATGATGGTGTAGTTCAT
  ATAGGCTATGATAATAACTTTGAATTTAAAACTGAGCAATTTAAAATGTCTAAATCTAGA
  AATTTATTAAAGAACAGAAGTCAAAATTATGCGCTCATAAGATTATTAAATTGGCTTAGA
  ACAACAAATTAA
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⊟Protein

⊟General

• locus tag: SACOL_RS06650 [old locus tag: SACOL1303 ]
• symbol: SACOL_RS06650
• description: competence protein CinA
• length: 383
• theoretical pI: 6.19719
• theoretical MW: 43267.2
• GRAVY: -0.27389

⊟Function

• ⊞⊞TIGRFAM:
  Genetic information processing DNA metabolism DNA replication, recombination, and repair competence/damage-inducible protein CinA N-terminal domain (TIGR00200; HMM-score: 284.7)
  and 2 more
  molybdenum cofactor synthesis domain (TIGR00177; HMM-score: 110.5)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdenum cofactor biosynthesis protein B (TIGR02667; HMM-score: 26.3)
• TheSEED: see SACOL1303
• ⊞⊞PFAM:
  no clan defined MoCF_biosynth; Probable molybdopterin binding domain (PF00994; HMM-score: 127.3)
  and 3 more
  CinA_KH; Damage-inducible protein CinA KH domain (PF18146; HMM-score: 90)
  EF-G_C (CL0437) SBDS_domain_II; SBDS protein, domain II (PF09377; HMM-score: 13.7)
  P-loop_NTPase (CL0023) TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 12.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9967
  • Cytoplasmic Membrane Score: 0.0012
  • Cell wall & surface Score: 0.0002
  • Extracellular Score: 0.0018
• LocateP:
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.030419
  • TAT(Tat/SPI): 0.000964
  • LIPO(Sec/SPII): 0.010134
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 445942506 NCBI
• RefSeq: WP_000020361 NCBI
• UniProt: see SACOL1303

⊟Protein sequence

• MSIAIIAVGSELLLGQIANTNGQFLSKVFNEIGQNVLEHKVIGDNKKRLESSVRHALEKYDTVILTGGLGPTKDDLTKHTVAQIVGKDLVIDEPSLKYIESYFEEQGQEMTPNNKQQALVIEGSTVLTNHHGMAPGMMVNFENKQIILLPGPPKEMQPMVKNELLSHFINHNRIIHSELLRFAGIGESKVETILIDLIDKQTNPTIAPLAGSHEVYIRLTANADSKEQAQSLIQPVKQEILDRIGEYYYGSDDTLIEQAVIKKIHEPFVIYDGITNGALYHRLKEVDLNDVLKGMINHNENFVDINKPIEQQLKDAVQFVNKLFNVSSAIILLEYDGVVHIGYDNNFEFKTEQFKMSKSRNLLKNRSQNYALIRLLNWLRTTN

⊟Experimental data

• experimentally validated: see SACOL1303
• protein localization: see SACOL1303
• quantitative data / protein copy number per cell: see SACOL1303
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications