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NCBI: 26-AUG-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA0178 [new locus tag: SA_RS01065 ]
  • pan locus tag?: SAUPAN001024000
  • symbol: argC
  • pan gene symbol?: argC
  • synonym:
  • product: N-acetyl-gamma-glutamyl-phosphate reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA0178 [new locus tag: SA_RS01065 ]
  • symbol: argC
  • product: N-acetyl-gamma-glutamyl-phosphate reductase
  • replicon: chromosome
  • strand: -
  • coordinates: 208136..209167
  • length: 1032
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGATTAAAGTAGGTATCGTTGGCGGTAGCGGTTATGGCGCAATTGAATTAATTCGATTG
    TTACAAACACATCCTCATGTAACGATTGCACACATCTACTCACATTCAAAAGTAGATGAA
    CCGTTGAAATTAACATTTCCACATTTACAACATATTATGCAACATTTCGAAGCACTTACA
    GTGGACAATAATGACTGTGATGTAATTTTCTTTGCGACACCAGCACCCGTAAGTAAAACA
    TGTATCCCTCCCTTAGTAGAAAAAGGTATTCATGTTATCGATTTATCTGGCGCATTTAGA
    ATTAAGAATCGTGAAATATATGAAGCATATTACAAAGAAACTGCTGCAGCACAAGATGAT
    TTGAATCATGCTATTTACAGCATTTCAGAATGGCAATCGTTTGATAACAATGGAACGAAG
    CTCATTTCTAATCCTGGCTGTTTCCCTACAGCAACATTATTAGCATTACATCCACTTATT
    AGCGAAAAAATAGTAGATTTGTCATCTATTATTATTGATGCTAAGACCGGCGTGTCAGGT
    GCTGGTCGTTCATTATCACAACGTGTTCATTTTTCAGAAATGAATGAAAATCTAAGTGCT
    TATGCAATCGGAAACCATAAACACAAACCGGAAATCGAGCAATATTTATCTATCATTGCG
    GGTCAAGATGTATCAGTCATATTTACACCACATCTCGTACCAATGACACGAGGTATTTTA
    TCAACAATTTATGTCAAATTTTCATCTGAATATACGACTGAATCATTACATAAATTAATG
    ACCTCTTATTATGCTAATCAGCCATTTGTCAGAATTAGAGATATTGGGACTTTTCCAACC
    ACAAAAGAAGTACTCGGTAGTAACTACTGCGATATCGGTATCTATGTAGATGAAACAACA
    CAAACAGCAATTTTAGTATCAGTGATTGATAACCTTGTCAAAGGCGCAAGTGGTCAAGCC
    ATTCAAAATTTAAATATATTATATGATTTTGAAGTAACGACTGGCCTAAATCAATCACCA
    GTTTATCCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1032

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA0178 [new locus tag: SA_RS01065 ]
  • symbol: ArgC
  • description: N-acetyl-gamma-glutamyl-phosphate reductase
  • length: 343
  • theoretical pI: 6.22283
  • theoretical MW: 37924
  • GRAVY: 0.012828

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 1.2.1.38?  ExPASy
    N-acetyl-gamma-glutamyl-phosphate reductase N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH
  • ⊞TIGRFAM:
    Metabolism Amino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01850; EC 1.2.1.38; HMM-score: 439.2)
    and 4 more
    Metabolism Amino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01851; EC 1.2.1.38; HMM-score: 97.7)
    Metabolism Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR00978; EC 1.2.1.11; HMM-score: 60.4)
    Metabolism Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR01296; EC 1.2.1.11; HMM-score: 47.3)
    acetaldehyde dehydrogenase (acetylating) (TIGR03215; EC 1.2.1.10; HMM-score: 13)
  • TheSEED  :
    • N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38)
    Amino Acids and Derivatives Arginine; urea cycle, polyamines Arginine Biosynthesis extended  N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38)
  • ⊞PFAM:
    GADPH_aa-bio_dh (CL0139) Semialdhyde_dhC_1; Semialdehyde dehydrogenase, dimerisation domain (PF22698; HMM-score: 216.1)
    and 3 more
    Semialdhyde_dhC; Semialdehyde dehydrogenase, dimerisation domain (PF02774; HMM-score: 110.6)
    NADP_Rossmann (CL0063) Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain (PF01118; HMM-score: 92.1)
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold (PF01408; HMM-score: 17.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.99
    • Cytoplasmic Membrane Score: 0.0027
    • Cell wall & surface Score: 0.0005
    • Extracellular Score: 0.0069
  • ⊞LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006392
    • TAT(Tat/SPI): 0.000302
    • LIPO(Sec/SPII): 0.0007
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MIKVGIVGGSGYGAIELIRLLQTHPHVTIAHIYSHSKVDEPLKLTFPHLQHIMQHFEALTVDNNDCDVIFFATPAPVSKTCIPPLVEKGIHVIDLSGAFRIKNREIYEAYYKETAAAQDDLNHAIYSISEWQSFDNNGTKLISNPGCFPTATLLALHPLISEKIVDLSSIIIDAKTGVSGAGRSLSQRVHFSEMNENLSAYAIGNHKHKPEIEQYLSIIAGQDVSVIFTPHLVPMTRGILSTIYVKFSSEYTTESLHKLMTSYYANQPFVRIRDIGTFPTTKEVLGSNYCDIGIYVDETTQTAILVSVIDNLVKGASGQAIQNLNILYDFEVTTGLNQSPVYP

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • ⊞regulator: ArgR* (repression) regulon

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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