From AureoWiki
Revision as of 03:14, 13 April 2025 by Adberti (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

Summary[edit | edit source]

  • pan ID?: SAUPAN005928000
  • symbol?: narG
  • synonym:
  • description?: nitrate reductase subunit alpha

      descriptions from strain specific annotations:

    • nitrate reductase subunit alpha
    • respiratory nitrate reductase subunit alpha
    • nitrate reductase, alpha subunit
    • respiratory nitrate reductase, alpha subunit
    • respiratory nitrate reductase alpha chain
    • nitrate reductase alpha subunit
    • pseudogene
  • strand?: -
  • coordinates?: 5991881..5995628
  • synteny block?: BlockID0046720
  • occurrence?: in 100% of 34 strains

narG : respiratory nitrate reductase subunit alpha [1]

Respiratory nitrate reductase allows staphylococci to continue electron transport under anaerobic conditions with nitrate as a terminal electron acceptor. The alpha subunit is the catalytic center that uses its molybdopterin cofactor to reduce nitrate to nitrite using electrons provided by the beta subunit. Intriguingly, respiratory nitrogen reductase stimulates agr production, increases virulence and decreases the host immune response but only in USA300 staphylococci.

Orthologs[edit | edit source]

    COL:
    SACOL2395 (narG)
    N315:
    SA2185 (narG)
    NCTC8325:
    Newman:
    NWMN_2297 (narG)
    USA300_FPR3757:
    JSNZ:
    04-02981:
    SA2981_2334 (narG)
    08BA02176:
    C248_2444 (narG)
    11819-97:
    MS7_2412
    6850:
    RSAU_002235 (narG)
    71193:
    ST398NM01_2450
    ECT-R 2:
    ECTR2_2256
    ED133:
    SAOV_2442c
    ED98:
    SAAV_2462 (narG)
    HO 5096 0412:
    SAEMRSA15_22960 (narG)
    JH1:
    SaurJH1_2469
    JH9:
    SaurJH9_2421
    JKD6008:
    SAA6008_02438 (narG)
    JKD6159:
    SAA6159_02298 (narG)
    LGA251:
    SARLGA251_21790 (narG)
    M013:
    M013TW_2358
    MRSA252:
    SAR2486 (narG)
    MSHR1132:
    SAMSHR1132_22250
    MSSA476:
    SAS2288
    Mu3:
    SAHV_2381 (narG)
    Mu50:
    SAV2397 (narG)
    MW2:
    MW2319 (narG)
    RF122:
    SAB2276c (narG)
    ST398:
    SAPIG2450
    T0131:
    SAT0131_02588
    TCH60:
    HMPREF0772_10790 (narG)
    TW20:
    SATW20_25270 (narG)
    USA300_TCH1516:
    USA300HOU_2379 (narG)
    VC40:
    SAVC_10855

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757
JSNZ

Alignments[edit | edit source]

  • alignment of orthologues:

  1. Yujie Li, Ting Pan, Ruobing Cao, Wei Li, Zhien He, Baolin Sun
    Nitrate Reductase NarGHJI Modulates Virulence via Regulation of agr Expression in Methicillin-Resistant Staphylococcus aureus Strain USA300 LAC.
    Microbiol Spectr: 2023, 11(3);e0359622
    [PubMed:37199609] [WorldCat.org] [DOI] (I p)