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NCBI: 10-JUN-2013

Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1220 [new locus tag: SACOL_RS06250 ]
  • pan locus tag?: SAUPAN003490000
  • symbol: SACOL1220
  • pan gene symbol?: rqcH
  • synonym:
  • product: fibronectin/fibrinogen binding-like protein

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SACOL1220 [new locus tag: SACOL_RS06250 ]
  • symbol: SACOL1220
  • product: fibronectin/fibrinogen binding-like protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1228645..1230342
  • length: 1698
  • essential: unknown other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGGCTTATGATGGCTTATTTACAAAGAAAATGGTTGAGTCTCTACAATTTTTAACAACA
    GGACGCGTTCACAAAATCAATCAACCTGATAATGACACGATACTAATGGTTGTACGTCAA
    AATAGACAAAACCATCAATTGTTATTGTCAATCCATCCAAACTTTTCAAGATTACAATTG
    ACTACTAAAAAATATGATAATCCATTTAATCCACCCATGTTTGCGCGTGTTTTTAGAAAA
    CACTTAGAAGGTGGTATTATCGAATCGATTAAGCAAATTGGTAATGATCGTCGCATTGAA
    ATCGATATAAAGAGTAAAGATGAAATTGGCGATACTATTTACCGCACTGTCATCCTTGAG
    ATTATGGGTAAACATAGTAACTTAATTTTAGTAGATGAAAATCGCAAAATAATTGAAGGA
    TTTAAACACTTAACACCAAATACGAATCACTATCGTACAGTAATGCCAGGATTTAATTAT
    GAAGCACCACCTACTCAGCACAAAATAAATCCGTATGATATTACAGGTGCAGAGGTGTTG
    AAATATATCGATTTTAACGCAGGTAATATTGCTAAACAATTATTGAATCAGTTTGAAGGA
    TTTAGCCCTTTAATTACGAATGAAATCGTTAGTCGTCGTCAATTTATGACTTCATCAACA
    TTACCAGAAGCATTTGACGAAGTAATGGCAGAAACCAAGTTACCACCTACTCCTATTTTT
    CATAAAAATCATGAAACAGGTAAAGAGGATTTCTATTTTATAAAGTTAAATCAATTTAAT
    GATGATACAGTTACATACGATTCATTAAATGATTTGCTTGATCGTTTTTATGATGCGCGT
    GGCGAACGTGAACGCGTTAAACAACGTGCGAATGATTTAGTTCGATTTGTTCAACAGCAG
    TTGCACAAATATCAAAATAAATTAGCGAAGTTGATTGAAGAATATGAGCAGTCTAAAAAT
    AAAGATACTGAACAGTTATATGGTGAATTGATCACTGCTAATATATATCGAATTAAGCAA
    GGCGATAAAGAAGTGACGGCATTGAATTATTATACGAATGAAGAAGTTGTCATTCCTTTA
    AATCCTACAAAATCCCCATCAGCAAATGCTCAATATTATTATAAACAATATAATCGTATG
    AAAACGAGAGAACGTGAATTACAACATCAAATTCAATTGACGAAAGACAATATAGATTAT
    TTTTCAACAATCGAACAACAATTACATCATATTTCTGTCCATGACATTGATGAAATTAGA
    GATGAATTAGCAGAACAAGGCTTTATGAAACAGCGTAAAAATCAAACTAAGAAAAAGAAA
    GCGCAGATTCAATTACAACATTATGTATCAACTGATGGCGACGATATATATGTTGGTAAG
    AATAACAAGCAAAATGATTATTTAACAAATAAAAAAGCTAAAAAAACTCACACATGGTTA
    CACACAAAAGATATTCCTGGTTCACATGTCGTTATATTTAATGATGCACCAAGTGATACG
    ACAATCAAGGAAGCGGCTATGTTAGCAGGATACTTTTCAAAAGCTGGTAATTCTGGACAA
    ATACCTGTTGATTATACATTAATTAAAAATGTGCATAAACCATCAGGTGCAAAGCCTGGG
    TTTGTAACATATGACAATCAAAAAACTTTGTATGCTACACCTGATTATGAACTTATTCAA
    AAAATGAAACAATCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1698

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SACOL1220 [new locus tag: SACOL_RS06250 ]
  • symbol: SACOL1220
  • description: fibronectin/fibrinogen binding-like protein
  • length: 565
  • theoretical pI: 9.17033
  • theoretical MW: 65784
  • GRAVY: -0.772212

Function[edit | edit source]

  • TIGRFAM:
  • TheSEED  :
    • Fibronectin/fibrinogen-binding protein
  • PFAM:
    H2TH (CL0303) FbpA; Fibronectin-binding protein A N-terminus (FbpA) (PF05833; HMM-score: 473.1)
    and 5 more
    no clan defined DUF814; Domain of unknown function (DUF814) (PF05670; HMM-score: 91.8)
    Apolipoprotein; Apolipoprotein A1/A4/E domain (PF01442; HMM-score: 16)
    Tropomyosin-lke (CL0452) CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels (PF16526; HMM-score: 15.3)
    no clan defined GAT; GAT domain (PF03127; HMM-score: 14.2)
    HotDog (CL0050) YiiD_C; Putative thioesterase (yiiD_Cterm) (PF09500; HMM-score: 11.1)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002293
    • TAT(Tat/SPI): 0.000215
    • LIPO(Sec/SPII): 0.001228
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MAYDGLFTKKMVESLQFLTTGRVHKINQPDNDTILMVVRQNRQNHQLLLSIHPNFSRLQLTTKKYDNPFNPPMFARVFRKHLEGGIIESIKQIGNDRRIEIDIKSKDEIGDTIYRTVILEIMGKHSNLILVDENRKIIEGFKHLTPNTNHYRTVMPGFNYEAPPTQHKINPYDITGAEVLKYIDFNAGNIAKQLLNQFEGFSPLITNEIVSRRQFMTSSTLPEAFDEVMAETKLPPTPIFHKNHETGKEDFYFIKLNQFNDDTVTYDSLNDLLDRFYDARGERERVKQRANDLVRFVQQQLHKYQNKLAKLIEEYEQSKNKDTEQLYGELITANIYRIKQGDKEVTALNYYTNEEVVIPLNPTKSPSANAQYYYKQYNRMKTRERELQHQIQLTKDNIDYFSTIEQQLHHISVHDIDEIRDELAEQGFMKQRKNQTKKKKAQIQLQHYVSTDGDDIYVGKNNKQNDYLTNKKAKKTHTWLHTKDIPGSHVVIFNDAPSDTTIKEAAMLAGYFSKAGNSGQIPVDYTLIKNVHKPSGAKPGFVTYDNQKTLYATPDYELIQKMKQS

Experimental data[edit | edit source]

  • experimentally validated: PeptideAtlas
  • protein localization: Cytoplasmic [1] [2] [3]
  • quantitative data / protein copy number per cell: 574 [4]
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: 12.69 h [5]

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

  1. Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
    A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
    PLoS One: 2009, 4(12);e8176
    [PubMed:19997597] [WorldCat.org] [DOI] (I e)
  2. Kristina Hempel, Florian-Alexander Herbst, Martin Moche, Michael Hecker, Dörte Becher
    Quantitative proteomic view on secreted, cell surface-associated, and cytoplasmic proteins of the methicillin-resistant human pathogen Staphylococcus aureus under iron-limited conditions.
    J Proteome Res: 2011, 10(4);1657-66
    [PubMed:21323324] [WorldCat.org] [DOI] (I p)
  3. Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
    The Staphylococcus aureus proteome.
    Int J Med Microbiol: 2014, 304(2);110-20
    [PubMed:24439828] [WorldCat.org] [DOI] (I p)
  4. Daniela Zühlke, Kirsten Dörries, Jörg Bernhardt, Sandra Maaß, Jan Muntel, Volkmar Liebscher, Jan Pané-Farré, Katharina Riedel, Michael Lalk, Uwe Völker, Susanne Engelmann, Dörte Becher, Stephan Fuchs, Michael Hecker
    Costs of life - Dynamics of the protein inventory of Staphylococcus aureus during anaerobiosis.
    Sci Rep: 2016, 6;28172
    [PubMed:27344979] [WorldCat.org] [DOI] (I e)
  5. Stephan Michalik, Jörg Bernhardt, Andreas Otto, Martin Moche, Dörte Becher, Hanna Meyer, Michael Lalk, Claudia Schurmann, Rabea Schlüter, Holger Kock, Ulf Gerth, Michael Hecker
    Life and death of proteins: a case study of glucose-starved Staphylococcus aureus.
    Mol Cell Proteomics: 2012, 11(9);558-70
    [PubMed:22556279] [WorldCat.org] [DOI] (I p)

Relevant publications[edit | edit source]