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NCBI: 10-JUN-2013

Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1056 [new locus tag: SACOL_RS05385 ]
  • pan locus tag?: SAUPAN003250000
  • symbol: sspB1
  • pan gene symbol?: sspB
  • synonym:
  • product: cysteine protease precursor SspB

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SACOL1056 [new locus tag: SACOL_RS05385 ]
  • symbol: sspB1
  • product: cysteine protease precursor SspB
  • replicon: chromosome
  • strand: -
  • coordinates: 1061753..1062934
  • length: 1182
  • essential: unknown other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGAATAGTTCATGTAAATCTAGAGTATTCAATATTATAAGCATCATAATGGTTTCAATG
    CTTATTTTATCACTAGGCGCATTTGCTAATAACAATAAAGCCAAAGCCGATTCACACTCT
    AAACAGCTAGAAATTAATGTTAAGAGTGACAAAGTACCTCAAAAAGTAAAAGATCTAGCA
    CAACAACAATTTGCTGGTTATGCTAAAGCATTAGATAAACAAAGTAATGCAAAAACTGGT
    AAATATGAACTTGGCGAAGCTTTTAAAATTTATAAATTTAATGGTGAAGAAGATAATAGT
    TACTATTATCCAGTTATAAAAGACGGTAAAATTGTTTATACTTTAACACTTAGTCCTAAA
    AATAAAGATGATTTAAACAAATCAAAAGAAGACATGAATTACAGTGTTAAAATTTCAAAC
    TTCATCGCTAAAGATTTAGACCAAATTAAAGATAAAAATTCAAATATCACTGTTCTTACT
    GATGAAAAAGGGTTTTATTTTGAAGAAGATGGCAAAGTTAGATTAGTAAAAGCTACGCCT
    CTACCTGGTAATGTAAAAGAAAAAGAAAGTGCTAAAACAGTTTCAGCAAAATTGAAACAA
    GAGTTAAAAAATACAGTAACACCTACTAAAGTTGAAGAAAACGAAGCGATACAAGAAGAT
    CAAGTTCAATATGAAAATACATTAAAAAACTTCAAAATTAGAGAACAACAATTCGATAAC
    TCATGGTGTGCAGGATTCAGTATGGCAGCATTATTAAATGCAACTAAAAATACAGACACT
    TATAATGCACATGATATTATGCGTACATTATACCCTGAAGTAAGTGAGCAAGACCTTCCT
    AATTGTGCAACATTCCCTAATCAAATGATTGAATACGGTAAATCACAAGGCAGAGATATT
    CATTATCAAGAAGGCGTACCATCATATGAACAAGTTGATCAACTTACAAAAGATAATGTA
    GGAATTATGATCCTTGCACAAAGTGTATCTCAAAACCCTAATGACCCACATTTAGGACAT
    GCGCTAGCAGTTGTTGGTAATGCTAAAATTAATGACCAAGAAAAACTTATTTACTGGAAT
    CCTTGGGATACAGAATTATCAATCCAAGATGCAGATTCAAGCCTATTACATTTATCATTC
    AATCGTGATTATAACTGGTATGGTTCAATGATAGGTTACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1182

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SACOL1056 [new locus tag: SACOL_RS05385 ]
  • symbol: SspB1
  • description: cysteine protease precursor SspB
  • length: 393
  • theoretical pI: 5.75782
  • theoretical MW: 44518.8
  • GRAVY: -0.655471

Function[edit | edit source]

  • reaction:
    EC 3.4.22.-?  ExPASy
  • TIGRFAM:
  • TheSEED  :
    • Staphopain B precursor (EC 3.4.22.-)
  • PFAM:
    Peptidase_CA (CL0125) Peptidase_C47; Staphopain peptidase C47 (PF05543; HMM-score: 316.3)
    Cystatin (CL0121) Staphopain_pro; Staphopain proregion (PF14731; HMM-score: 269.1)
    and 1 more
    no clan defined NusG_II; NusG domain II (PF07009; HMM-score: 7.2)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 10
    • Internal Helix: 1
  • LocateP: Secretory(released) (with CS)
    • Prediction by SwissProt Classification: Extracellular
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: 0.5
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: NKAKADSH
  • SignalP: Signal peptide SP(Sec/SPI) length 36 aa
    • SP(Sec/SPI): 0.953122
    • TAT(Tat/SPI): 0.01408
    • LIPO(Sec/SPII): 0.023049
    • Cleavage Site: CS pos: 36-37. AKA-DS. Pr: 0.7703
  • predicted transmembrane helices (TMHMM): 1

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MNSSCKSRVFNIISIIMVSMLILSLGAFANNNKAKADSHSKQLEINVKSDKVPQKVKDLAQQQFAGYAKALDKQSNAKTGKYELGEAFKIYKFNGEEDNSYYYPVIKDGKIVYTLTLSPKNKDDLNKSKEDMNYSVKISNFIAKDLDQIKDKNSNITVLTDEKGFYFEEDGKVRLVKATPLPGNVKEKESAKTVSAKLKQELKNTVTPTKVEENEAIQEDQVQYENTLKNFKIREQQFDNSWCAGFSMAALLNATKNTDTYNAHDIMRTLYPEVSEQDLPNCATFPNQMIEYGKSQGRDIHYQEGVPSYEQVDQLTKDNVGIMILAQSVSQNPNDPHLGHALAVVGNAKINDQEKLIYWNPWDTELSIQDADSSLLHLSFNRDYNWYGSMIGY

Experimental data[edit | edit source]

  • experimentally validated: PeptideAtlas
  • protein localization: Signal peptide containing [1] [2] [3] [4]
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

  1. Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
    A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
    PLoS One: 2009, 4(12);e8176
    [PubMed:19997597] [WorldCat.org] [DOI] (I e)
  2. Kristina Hempel, Jan Pané-Farré, Andreas Otto, Susanne Sievers, Michael Hecker, Dörte Becher
    Quantitative cell surface proteome profiling for SigB-dependent protein expression in the human pathogen Staphylococcus aureus via biotinylation approach.
    J Proteome Res: 2010, 9(3);1579-90
    [PubMed:20108986] [WorldCat.org] [DOI] (I p)
  3. Kristina Hempel, Florian-Alexander Herbst, Martin Moche, Michael Hecker, Dörte Becher
    Quantitative proteomic view on secreted, cell surface-associated, and cytoplasmic proteins of the methicillin-resistant human pathogen Staphylococcus aureus under iron-limited conditions.
    J Proteome Res: 2011, 10(4);1657-66
    [PubMed:21323324] [WorldCat.org] [DOI] (I p)
  4. Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
    The Staphylococcus aureus proteome.
    Int J Med Microbiol: 2014, 304(2);110-20
    [PubMed:24439828] [WorldCat.org] [DOI] (I p)

Relevant publications[edit | edit source]